Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P00797

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
23	unknown peptidase	1-403	P	release of a signal peptide	NT	Ishizuka et al., 1991
66	cathepsin B	24-406	P	normal turnover		Jutras & Reudelhuber, 1999
66	coagulation factor XIIa	24-406	P			Ratnoff, 2004
66	kallikrein-related peptidase 4	1-406	P		CS	Matsumura et al., 2005
66	PCSK1 peptidase	24-406	P			Seidah & Chretien, 1994
66	PCSK5 peptidase	24-406	P			Seidah & Chretien, 2004