Sequence features for peptidase S08.072: PCSK1 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

 

MERNUM Species Sequence length Peptidase unit Active site residues Source
MER0270394 Ailuropoda melanoleuca 753 143-441 D167, H208, N309, S382 UNIPROT:D2HUX9
MER0270394 Ailuropoda melanoleuca 753 143-441 D167, H208, N309, S382 UNIPROT:D2HUX9
MER0325335 Amphimedon queenslandica 296 150-292 D172, H209, missing, missing GENBANK:XP_003390931
MER0688144 Apaloderma vittatum 686 83-379 D107, H148, N249, S322 GENBANK:XP_009874731
MER0000369 Aplysia californica 712 170-458 D193, H234, N335, S408 UNIPROT:Q16971
MER0000369 Aplysia californica 712 170-458 D193, H234, N335, S408 UNIPROT:Q16971
MER0687282 Aptenodytes forsteri 690 85-383 D109, H150, N251, S324 GENBANK:XP_009278952
MER0686305 Aquila chrysaetos 748 143-441 D167, H208, N309, S382 GENBANK:XP_011598671
MER0554928 Astatotilapia burtoni 769 148-446 D172, H213, N314, S387 GENBANK:XP_005918726
MER0363962 Astyanax mexicanus 754 149-447 D173, H214, N315, S388 UNIPROT:W5KGZ8
MER0363962 Astyanax mexicanus 754 149-447 D173, H214, N315, S388 UNIPROT:W5KGZ8
MER0410754 Balaenoptera acutorostrata 753 143-441 D167, H208, N309, S382 GENBANK:XP_007197531
MER0679852 Balearica regulorum 745 140-438 D164, H205, N306, S379 GENBANK:XP_010305716
MER0679785 Bison bison 753 143-441 D167, H208, N309, S382 GENBANK:XP_010830254
MER0427508 Bombyx mori 718 184-482 D208, H249, N350, S423 GENBANK:XP_004925623
MER0430634 Bos grunniens 753 143-441 D167, H208, N309, S382 UNIPROT:L8ICF0
MER0430634 Bos grunniens 753 143-441 D167, H208, N309, S382 UNIPROT:L8ICF0
MER0005965 Bos taurus 753 143-441 D167, H208, N309, S382 UNIPROT:Q9GLR1
MER0005965 Bos taurus 753 143-441 D167, H208, N309, S382 UNIPROT:Q9GLR1
MER0005965 Bos taurus 753 143-441 D167, H208, N309, S382 UNIPROT:Q9GLR1
MER0001994 Branchiostoma californiense 774 147-447 D174, H215, N316, S389 UNIPROT:Q17124
MER0001994 Branchiostoma californiense 774 147-447 D174, H215, N316, S389 UNIPROT:Q17124
MER0192116 Branchiostoma floridae 730 103-403 D130, H171, N272, S345 GENBANK:XP_002243490
MER0580454 Bubalus bubalis 753 143-441 D167, H208, N309, S382 GENBANK:XP_006051243
MER0678676 Buceros rhinoceros 705 100-398 D124, H165, N266, S339 GENBANK:XP_010138347
MER0325088 Callithrix jacchus 752 140-415 D167, H208, N309, S382 UNIPROT:F7EBE4
MER0325088 Callithrix jacchus 752 140-415 D167, H208, N309, S382 UNIPROT:F7EBE4
MER0495230 Callorhinchus milii 282 22-256 missing, H58, N159, S240 GENBANK:XP_007884004
MER0581743 Calypte anna 770 167-465 D191, H232, N333, S406 GENBANK:XP_008497895
MER0677900 Camelus dromedarius 752 143-441 D167, H208, N309, S382 GENBANK:XP_010992267
MER0514823 Camelus ferus 753 143-441 D167, H208, N309, S382 GENBANK:XP_006194562
MER0056313 Canis lupus familiaris 754 143-442 D167, H208, N309, S383 GENBANK:XP_536293
MER0546616 Capra hircus 753 143-441 D167, H208, N309, S382 GENBANK:XP_005683506
MER0676208 Cariama cristata 688 83-381 D107, H148, N249, S322 GENBANK:XP_009706152
MER0103694 Cavia porcellus 755 143-441 D167, H208, N309, S382 GENBANK:XP_003479481
MER0537263 Ceratotherium simum 753 143-441 D167, H208, N309, S382 GENBANK:XP_004420410
MER0585735 Cercopithecus sabaeus 749 143-441 D167, H208, N309, S382 GENBANK:XP_007977229
MER0672371 Charadrius vociferus 685 88-378 D112, H153, N254, S327 GENBANK:XP_009882636
MER0591653 Chelonia mydas 714 109-407 D133, H174, N275, S348 GENBANK:XP_007054162
MER0584425 Chinchilla lanigera 752 143-441 D167, H208, N309, S382 GENBANK:XP_005382289
MER0577471 Chrysemys picta 749 144-442 D168, H209, N310, S383 GENBANK:XP_005284059
MER0575962 Chrysochloris asiatica 753 143-441 D167, H208, N309, S382 GENBANK:XP_006867949
MER0671013 Colius striatus 686 83-379 D107, H148, N249, S322 GENBANK:XP_010194586
MER0669801 Colobus angolensis 749 143-441 D167, H208, N309, S382 GENBANK:XP_011799681
MER0573817 Condylura cristata 718 108-406 D132, H173, N274, S347 GENBANK:XP_004678479
MER0572787 Corvus brachyrhynchos 767 159-460 D183, H224, N325, S398 GENBANK:XP_008632804
MER0668311 Corvus cornix 702 97-395 D121, H162, N263, S336 GENBANK:XP_010398457
MER0309466 Cricetulus griseus 753 140-415 D167, H208, N309, S382 GENBANK:XP_003500048
MER0665447 Cuculus canorus 716 111-409 D135, H176, N277, S350 GENBANK:XP_009561273
MER0567978 Cynoglossus semilaevis 784 158-456 D182, H223, N324, S397 GENBANK:XP_008318899
MER0325122 Danaus plexippus 663 144-421 D173, H214, N315, S388 UNIPROT:G6D422
MER0325122 Danaus plexippus 663 144-421 D173, H214, N315, S388 UNIPROT:G6D422
MER0175084 Danio rerio 755 143-435 D170, H211, N312, S385 UNIPROT:B6VCA1
MER0175084 Danio rerio 755 143-435 D170, H211, N312, S385 UNIPROT:B6VCA1
MER0325094 Daphnia pulex 731 221-518 D251, H292, N393, S466 UNIPROT:E9FZ50
MER0325094 Daphnia pulex 731 221-518 D251, H292, N393, S466 UNIPROT:E9FZ50
MER0325091 Dicentrarchus labrax 775 147-422 D174, H215, N316, S389 UNIPROT:E6ZG11
MER0325091 Dicentrarchus labrax 775 147-422 D174, H215, N316, S389 UNIPROT:E6ZG11
MER0599140 Echinops telfairi 753 143-441 D167, H208, N309, S382 GENBANK:XP_004703532
MER0664050 Egretta garzetta 846 221-534 D256, H297, N398, S471 GENBANK:XP_009632421
MER0564794 Elephantulus edwardii 753 143-441 D167, H208, N309, S382 GENBANK:XP_006885437
MER0563793 Eptesicus fuscus 753 143-441 D167, H208, N309, S382 GENBANK:XP_008142748
MER0098824 Equus caballus 754 143-441 D167, H208, N309, S382 UNIPROT:F6TCF0
MER0098824 Equus caballus 754 143-441 D167, H208, N309, S382 UNIPROT:F6TCF0
MER0562002 Equus przewalskii 754 143-441 D167, H208, N309, S382 GENBANK:XP_008532746
MER0614728 Erinaceus europaeus 753 143-441 D167, H208, N309, S382 GENBANK:XP_007529973
MER0659317 Esox lucius 778 151-449 D175, H216, N317, S390 GENBANK:XP_010879137
MER0610679 Felis catus 753 143-441 D167, H208, N309, S382 UNIPROT:M3W5Q0
MER0610679 Felis catus 753 143-441 D167, H208, N309, S382 UNIPROT:M3W5Q0
MER0569891 Ficedula albicollis 749 144-442 D168, H209, N310, S383 UNIPROT:U3JJX3
MER0569891 Ficedula albicollis 749 144-442 D168, H209, N310, S383 UNIPROT:U3JJX3
MER0655537 Fukomys damarensis 754 143-441 D167, H208, N309, S382 UNIPROT:A0A091DTA5
MER0655537 Fukomys damarensis 754 143-441 D167, H208, N309, S382 UNIPROT:A0A091DTA5
MER0557748 Galeopterus variegatus 753 143-441 D167, H208, N309, S382 GENBANK:XP_008567361
MER0403103 Gallus gallus 748 143-441 D167, H208, N309, S382 UNIPROT:F1NB95
MER0403103 Gallus gallus 748 143-441 D167, H208, N309, S382 UNIPROT:F1NB95
MER0653769 Gavia stellata 688 83-381 D107, H148, N249, S322 UNIPROT:A0A093ER99
MER0653769 Gavia stellata 688 83-381 D107, H148, N249, S322 UNIPROT:A0A093ER99
MER0609011 Gorilla gorilla 753 143-441 D167, H208, N309, S382 UNIPROT:G3QVR2
MER0609011 Gorilla gorilla 753 143-441 D167, H208, N309, S382 UNIPROT:G3QVR2
MER0652677 Haliaeetus albicilla 714 101-402 D136, H177, N278, S351 GENBANK:XP_009923295
MER0651694 Haliaeetus leucocephalus 749 144-442 D168, H209, N310, S383 GENBANK:XP_010567067
MER0039091 Haliotis rubra 145 1-145 missing, H1, N102, missing UNIPROT:Q7YT67
MER0039091 Haliotis rubra 145 1-145 missing, H1, N102, missing UNIPROT:Q7YT67
MER0325084 Heterocephalus glaber 755 140-415 D167, H208, N309, S382 GENBANK:EHB12786
MER0000376 Homo sapiens 753 143-441 D167, H208, N309, S382 GENBANK:NP_001171347
MER0000376 Homo sapiens 753 143-441 D167, H208, N309, S382 GENBANK:NP_001171347
MER0000376 Homo sapiens 753 143-441 D167, H208, N309, S382 GENBANK:NP_001171347
MER0000376 Homo sapiens 753 143-441 D167, H208, N309, S382 GENBANK:NP_001171347
MER0163952 Hydra magnipapillata 863 159-456 D182, H223, N324, S397 GENBANK:XP_002155196
MER0106514 Ictidomys tridecemlineatus 753 143-441 D167, H208, N309, S382 GENBANK:XP_005326203
MER0649677 Larimichthys crocea 775 150-448 D174, H215, N316, S389 GENBANK:XP_010741599
MER0549866 Lipotes vexillifer 753 143-441 D167, H208, N309, S382 GENBANK:XP_007466932
MER0000388 Lophius americanus 775 147-439 D174, H215, N316, S389 UNIPROT:Q91065
MER0000388 Lophius americanus 775 147-439 D174, H215, N316, S389 UNIPROT:Q91065
MER0102966 Loxodonta africana 753 143-441 D167, H208, N309, S382 UNIPROT:G3SVS6
MER0102966 Loxodonta africana 753 143-441 D167, H208, N309, S382 UNIPROT:G3SVS6
MER0325085 Macaca fascicularis 753 140-415 D167, H208, N309, S382 UNIPROT:G7P7Z4
MER0325085 Macaca fascicularis 753 140-415 D167, H208, N309, S382 UNIPROT:G7P7Z4
MER0325078 Macaca mulatta 753 140-415 D167, H208, N309, S382 UNIPROT:G7MVG7
MER0325078 Macaca mulatta 753 140-415 D167, H208, N309, S382 UNIPROT:G7MVG7
MER0647521 Manacus vitellinus 736 131-429 D155, H196, N297, S370 GENBANK:XP_008921955
MER0646393 Mandrillus leucophaeus 749 143-441 D167, H208, N309, S382 GENBANK:XP_011844815
MER0542053 Maylandia zebra 769 148-446 D172, H213, N314, S387 GENBANK:XP_004545299
MER0325317 Meleagris gallopavo 135 1-128 missing, missing, N79, missing GENBANK:XP_003213705
MER0538310 Microtus ochrogaster 754 143-441 D167, H208, N309, S382 GENBANK:XP_005356618
MER0005932 Mus cookii 753 143-441 D167, H208, N309, S382 PIR:JX0171
MER0005932 Mus cookii 753 143-441 D167, H208, N309, S382 PIR:JX0171
MER0005932 Mus cookii 753 143-441 D167, H208, N309, S382 PIR:JX0171
MER0005932 Mus cookii 753 143-441 D167, H208, N309, S382 PIR:JX0171
MER0000379 Mus musculus 753 140-432 D167, H208, N309, S382 PIR:KXMSC1
MER0000379 Mus musculus 753 140-432 D167, H208, N309, S382 PIR:KXMSC1
MER0565969 Myotis brandtii 753 143-441 D167, H208, N309, S382 GENBANK:XP_005871585
MER0613178 Myotis davidii 736 143-432 D167, N207, N300, S373 GENBANK:XP_006775652
MER0236136 Myotis lucifugus 753 143-441 D167, H208, N309, S382 UNIPROT:G1P8D0
MER0236136 Myotis lucifugus 753 143-441 D167, H208, N309, S382 UNIPROT:G1P8D0
MER0639950 Nannospalax galili 752 143-441 D167, H208, N309, S382 GENBANK:XP_008826199
MER0536106 Neolamprologus brichardi 769 148-446 D172, H213, N314, S387 GENBANK:XP_006784634
MER0638418 Nestor notabilis 688 83-381 D107, H148, N249, S322 GENBANK:XP_010016499
MER0636452 Nipponia nippon 756 147-449 D171, H212, N313, S390 GENBANK:XP_009466910
MER0636688 Nipponia nippon 619 8-307 D33, H78, N179, S252 GENBANK:XP_009470732
MER0206910 Notothenia coriiceps 769 150-448 D174, H215, N316, S389 GENBANK:XP_010782965
MER0533918 Ochotona princeps 749 143-441 D167, H208, N309, S382 GENBANK:XP_004586247
MER0533246 Octodon degus 766 143-441 D167, H208, N309, S382 GENBANK:XP_004625484
MER0531398 Odobenus rosmarus 753 143-441 D167, H208, N309, S382 GENBANK:XP_004406658
MER0633995 Opisthocomus hoazin 740 135-433 D159, H200, N301, S374 GENBANK:XP_009935379
MER0529019 Orcinus orca 753 143-441 D167, H208, N309, S382 GENBANK:XP_004263564
MER0325092 Oreochromis niloticus 769 145-420 D172, H213, N314, S387 UNIPROT:I3KX34
MER0325092 Oreochromis niloticus 769 145-420 D172, H213, N314, S387 UNIPROT:I3KX34
MER0097845 Ornithorhynchus anatinus 758 149-447 D173, H214, N315, S388 GENBANK:XP_001512273
MER0528048 Orycteropus afer 753 143-441 D167, H208, N309, S382 GENBANK:XP_007940734
MER0110672 Oryzias latipes 583 1-295 D19, H61, N162, S237 GENBANK:XP_004077739
MER0402958 Otolemur garnettii 752 143-441 D167, H208, N309, S382 GENBANK:XP_003799753
MER0005974 Ovis aries 753 143-441 D167, H208, N309, S382 UNIPROT:W5Q845
MER0005974 Ovis aries 753 143-441 D167, H208, N309, S382 UNIPROT:W5Q845
MER0402951 Pan paniscus 753 143-441 D167, H208, N309, S382 GENBANK:XP_003822800
MER0053334 Pan troglodytes 753 143-441 D167, H208, N309, S382 UNIPROT:H2QR92
MER0053334 Pan troglodytes 753 143-441 D167, H208, N309, S382 UNIPROT:H2QR92
MER0519257 Panthera tigris 753 143-441 D167, H208, N309, S382 GENBANK:XP_007078962
MER0516375 Pantholops hodgsonii 753 143-441 D167, H208, N309, S382 GENBANK:XP_005982314
MER0525805 Papio anubis 749 143-441 D167, H208, N309, S382 UNIPROT:A0A096MPL7
MER0525805 Papio anubis 749 143-441 D167, H208, N309, S382 UNIPROT:A0A096MPL7
MER0632569 Pelecanus crispus 734 129-427 D153, H194, N295, S368 GENBANK:XP_009490053
MER0187435 Phaethon lepturus 696 91-389 D115, H156, N257, S330 UNIPROT:A0A091TVP5
MER0187435 Phaethon lepturus 696 91-389 D115, H156, N257, S330 UNIPROT:A0A091TVP5
MER0520350 Physeter catodon 753 143-441 D167, H208, N309, S382 GENBANK:XP_007107897
MER0521964 Poecilia formosa 776 150-448 D174, H215, N316, S389 GENBANK:XP_007554353
MER0523972 Poecilia formosa 753 147-445 D171, H212, N313, S386 GENBANK:XP_006118738
MER0514444 Poecilia reticulata 779 150-448 D174, H215, N316, S389 GENBANK:XP_008407682
MER0126193 Pongo abelii 753 143-441 D167, H208, N309, S382 UNIPROT:Q5R7S5
MER0126193 Pongo abelii 753 143-441 D167, H208, N309, S382 UNIPROT:Q5R7S5
MER0515469 Pteropus alecto 746 143-441 D167, H208, N309, S382 UNIPROT:L5KJL9
MER0515469 Pteropus alecto 746 143-441 D167, H208, N309, S382 UNIPROT:L5KJL9
MER0444586 Python bivittatus 747 143-441 D167, H208, N309, S382 GENBANK:XP_007439683
MER0042895 Rana catesbeiana 736 144-442 D168, H209, N310, S383 UNIPROT:Q76FG1
MER0042895 Rana catesbeiana 736 144-442 D168, H209, N310, S383 UNIPROT:Q76FG1
MER0005971 Rana ridibunda 736 144-442 D168, H209, N310, S383 UNIPROT:O93583
MER0005971 Rana ridibunda 736 144-442 D168, H209, N310, S383 UNIPROT:O93583
MER0000386 Rattus norvegicus 752 140-432 D167, H208, N309, S382 PIR:KXRTC1
MER0000386 Rattus norvegicus 752 140-432 D167, H208, N309, S382 PIR:KXRTC1
MER0552923 Rhinopithecus roxellana 749 143-441 D167, H208, N309, S382 GENBANK:XP_010352064
MER0512681 Saimiri boliviensis 753 143-441 D167, H208, N309, S382 GENBANK:XP_003920786
MER0415623 Sarcophilus harrisii 752 143-441 D167, H208, N309, S382 UNIPROT:G3VJH4
MER0415623 Sarcophilus harrisii 752 143-441 D167, H208, N309, S382 UNIPROT:G3VJH4
MER0551020 Serinus canaria 810 205-503 D229, H270, N371, S444 GENBANK:XP_009096543
MER0476651 Stegastes partitus 778 150-448 D174, H215, N316, S389 GENBANK:XP_008278749
MER0517928 Struthio camelus 690 86-384 D110, H151, N252, S325 GENBANK:XP_009682918
MER0002977 Sus scrofa 753 143-441 D167, H208, N309, S382 PIR:S59959
MER0002977 Sus scrofa 753 143-441 D167, H208, N309, S382 PIR:S59959
MER0002977 Sus scrofa 753 143-441 D167, H208, N309, S382 PIR:S59959
MER0166807 Taeniopygia guttata 724 144-442 D168, H209, N310, S383 GENBANK:XP_002187974
MER0122152 Tetraodon nigroviridis 829 163-474 D190, H231, N351, S424 UNIPROT:Q4SD85
MER0122152 Tetraodon nigroviridis 829 163-474 D190, H231, N351, S424 UNIPROT:Q4SD85
MER0325304 Tetraodon nigroviridis 151 1-149 missing, H1, N102, missing UNIPROT:Q4SMP7
MER0325304 Tetraodon nigroviridis 151 1-149 missing, H1, N102, missing UNIPROT:Q4SMP7
MER0463697 Tinamus guttatus 790 147-483 D171, H212, N313, S386 GENBANK:XP_010211566
MER0483012 Trichechus manatus 753 143-441 D167, H208, N309, S382 GENBANK:XP_004375097
MER0598906 Tupaia chinensis 751 143-441 D167, H208, N309, S382 GENBANK:XP_006169919
MER0455208 Tyto alba 692 83-385 D107, H148, N249, S326 GENBANK:XP_009968979
MER0238021 Ursus maritimus 765 143-441 D167, H208, N309, S382 GENBANK:XP_008699127
MER0325076 Xenopus tropicalis 742 139-416 D168, H209, N310, S383 GENBANK:XP_002933476
MER0451567 Xiphophorus maculatus 772 150-448 D174, H215, N316, S389 UNIPROT:M3ZTQ7
MER0451567 Xiphophorus maculatus 772 150-448 D174, H215, N316, S389 UNIPROT:M3ZTQ7
MER0448286 Zonotrichia albicollis 747 144-442 D168, H209, N310, S383 GENBANK:XP_005491408