Substrates for peptidase S01.072: matriptase-3

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
	Q5RKT7	40-51	QQR+LIFAGKQLE	N	MS	-	Gln	Gln	Arg	Leu	Ile	Phe	Ala	Barré et al., 2014
	Q6ZVP2	111-129	GRRDRS+KAGGSLCTQLQPL	N	MS	Arg	Asp	Arg	Ser	Lys	Ala	Gly	Gly	Barré et al., 2014
14 kDa phosphohistidine phosphatase	Q9NRX4	25-47	peptide-Arg32+Ser-peptide	N	MS	Ser	Ala	Pro	Arg	Ser	Gly	Ala	Pro	Barré et al., 2014
40S ribosomal protein S2	P15880	196-214	IPAPR+GTGIVSAPVPKKLL	N	MS	Pro	Ala	Pro	Arg	Gly	Thr	Gly	Ile	Barré et al., 2014
40S ribosomal protein S2	P15880	196-213	IPAPR+GTGIVSAPVPKKL	N	MS	Pro	Ala	Pro	Arg	Gly	Thr	Gly	Ile	Barré et al., 2014
40S ribosomal protein S5	P46782	62-72	R+KAQCPIVERL	N	MS	-	-	-	Arg	Lys	Ala	Gln	Cys	Barré et al., 2014
40S ribosomal protein SA	Q86VC0	119-136	PR+LLVVTDPRADHQPLTE	N	MS	-	-	Pro	Arg	Leu	Leu	Val	Val	Barré et al., 2014
60 kDa heat shock protein, mitochondrial	P10809	156-207	peptide-Arg195+Lys-peptide	N	MS	Lys	Val	Gly	Arg	Lys	Gly	Val	Ile	Barré et al., 2014
60S ribosomal protein L11	P62913	61-87	peptide-Arg75+Gly-peptide	N	MS	Cys	Thr	Val	Arg	Gly	Ala	Lys	Ala	Barré et al., 2014
60S ribosomal protein L12	P30050	134-165	peptide-Arg146+His-peptide	N	MS	Val	Asp	Gly	Arg	His	Pro	His	Asp	Barré et al., 2014
60S ribosomal protein L13	P26373	193-211	GIRAKR+AKEAAEQDVEKKK	N	MS	Arg	Ala	Lys	Arg	Ala	Lys	Glu	Ala	Barré et al., 2014
Aconitate hydratase, mitochondrial	Q99798	141-151	R+RAKDINQEVY	N	MS	-	-	-	Arg	Arg	Ala	Lys	Asp	Barré et al., 2014
Actin, gamma-enteric smooth muscle	P63267	33-54	peptide-Arg40+His-peptide	N	MS	Gly	Arg	Pro	Arg	His	Gln	Gly	Val	Barré et al., 2014
ADP-ribosylation factor-like protein 9	Q6T311	113-121	IA+ANPVLPL	N	MS	-	-	Ile	Ala	Ala	Asn	Pro	Val	Barré et al., 2014
alpha-2-antiplasmin	P08697	40-491	peptide-Arg+Met-peptide	P		Ala	Met	Ser	Arg	Met	Ser	Leu	Ser	Szabo et al., 2005	24042
Alpha-endosulfine	Q6VUC6	103-121	LPQR+KSSLVTSKLAGGQVE	N	MS	Leu	Pro	Gln	Arg	Lys	Ser	Ser	Leu	Barré et al., 2014
Alpha-enolase	Q6GMP2	417-434	LGSKAKFAGR+NFRNPLAK	N	MS	Phe	Ala	Gly	Arg	Asn	Phe	Arg	Asn	Barré et al., 2014
Alpha-enolase	P06733	117-130	AVC+KAGAVEKGVPL	N	MS	-	Ala	Val	Cys	Lys	Ala	Gly	Ala	Barré et al., 2014
antithrombin-III	P01008	33-464	peptide-Arg+Ser-peptide	P		Ile	Ala	Gly	Arg	Ser	Leu	Asn	Pro	Szabo et al., 2005
Arf-GAP domain and FG repeat-containing protein 1	Q53R11	174-197	peptide-Arg186+Ser-peptide	N	MS	Val	Val	Gly	Arg	Ser	Gln	Gly	Gln	Barré et al., 2014
Aspartate aminotransferase, cytoplasmic	P17174	26-41	REDPDPR+KVNLGVGAY	N	MS	Pro	Asp	Pro	Arg	Lys	Val	Asn	Leu	Barré et al., 2014
Aspartate aminotransferase, mitochondrial	P00505	78-92	PSVR+KAEAQIAAKNL	N	MS	Pro	Ser	Val	Arg	Lys	Ala	Glu	Ala	Barré et al., 2014
ATP-dependent RNA helicase DDX3Y	O15523	524-542	VHRIGR+TGRVGNLGLATSF	N	MS	Arg	Ile	Gly	Arg	Thr	Gly	Arg	Val	Barré et al., 2014
ATP-dependent RNA helicase DDX54	Q8TDD1	54-72	ARAR+KLGPGRPLPTFPTSE	N	MS	Ala	Arg	Ala	Arg	Lys	Leu	Gly	Pro	Barré et al., 2014
Bcl-2-associated transcription factor 1	Q9NYF8	285-336	peptide-Arg318+Ser-peptide	N	MS	Ser	Arg	Gly	Arg	Ser	Ser	Phe	Tyr	Barré et al., 2014
cAMP-dependent protein kinase catalytic subunit gamma	P22612	231-240	EMA+VGFPPFY	N	MS	-	Glu	Met	Ala	Val	Gly	Phe	Pro	Barré et al., 2014
Catenin alpha-1	P35221	540-559	RTAGAIRGR+AARVIHVVTSE	N	MS	Ile	Arg	Gly	Arg	Ala	Ala	Arg	Val	Barré et al., 2014
Cathepsin S	P25774	130-149	VKYQGSCG+ACWAFSAVGALE	N	MS	Gly	Ser	Cys	Gly	Ala	Cys	Trp	Ala	Barré et al., 2014
CD2-associated protein	Q9Y5K6	42-56	LNGR+RGMFPDNFVKE	N	MS	Leu	Asn	Gly	Arg	Arg	Gly	Met	Phe	Barré et al., 2014
Cell division cycle and apoptosis regulator protein 1	Q5VUP6	133-150	PTPR+SSQQQTQPQKQRVF	N	MS	Pro	Thr	Pro	Arg	Ser	Ser	Gln	Gln	Barré et al., 2014
Chromosome alignment-maintaining phosphoprotein 1	Q96JM3	554-562	PR+KHALFPE	N	MS	-	-	Pro	Arg	Lys	His	Ala	Leu	Barré et al., 2014
Copper homeostasis protein cutC homolog	Q9NTM9	56-71	SEGGTTPSM+GVLQVVK	N	MS	Thr	Pro	Ser	Met	Gly	Val	Leu	Gln	Barré et al., 2014
Cyclic AMP-responsive element-binding protein 3-like protein 3	Q68CJ9	100-145	peptide-Thr135+Thr-peptide	N	MS	Cys	Ser	Thr	Thr	Thr	Pro	Gly	Pro	Barré et al., 2014
Desmin	Q8NEU6	103-119	TTR+TNEKVELQELNDRF	N	MS	-	Thr	Thr	Arg	Thr	Asn	Glu	Lys	Barré et al., 2014
Dual specificity mitogen-activated protein kinase kinase 2	P36507	2-20	LAR+RKPVLPALTINPTIAE	N	MS	-	Leu	Ala	Arg	Arg	Lys	Pro	Val	Barré et al., 2014
Elastin	P15502-4	464-492	peptide-Pro481+Gly-peptide	N	MS	Gly	Gly	Val	Pro	Gly	Val	Gly	Thr	Barré et al., 2014
Endoplasmin	P14625	236-254	PR+GNTLGRGTTITLVLKEE	N	MS	-	-	Pro	Arg	Gly	Asn	Thr	Leu	Barré et al., 2014
F-actin-capping protein subunit alpha-1	P52907	102-120	R+KEASDPQPEEADGGLKSW	N	MS	-	-	-	Arg	Lys	Glu	Ala	Ser	Barré et al., 2014
Far upstream element-binding protein 2	Q92945	439-457	VIGR+GGENVKAINQQTGAF	N	MS	Val	Ile	Gly	Arg	Gly	Gly	Glu	Asn	Barré et al., 2014
Farnesyl pyrophosphate synthase	P14324	138-152	VEPR+KQDADSLQRAW	N	MS	Val	Glu	Pro	Arg	Lys	Gln	Asp	Ala	Barré et al., 2014
Filamin-A	P21333	671-695	peptide-Arg678+Gly-peptide	N	MS	Val	Lys	Ala	Arg	Gly	Pro	Gly	Leu	Barré et al., 2014
Filensin	Q12934	183-210	peptide-Pro199+Ala-peptide	N	MS	Thr	Thr	Pro	Pro	Ala	Ser	Ile	Val	Barré et al., 2014
G-protein coupled receptor 98	Q8WXG9	280-293	IIPVV+RGKDNNGNL	N	MS	Ile	Pro	Val	Val	Arg	Gly	Lys	Asp	Barré et al., 2014
Glucokinase regulatory protein	Q14397	326-345	KKGHVYLVG+WQTLGIIAIMD	N	MS	Tyr	Leu	Val	Gly	Trp	Gln	Thr	Leu	Barré et al., 2014
Glutathione S-transferase omega-1	P78417	2-27	peptide-Arg7+Ser-peptide	N	MS	Glu	Ser	Ala	Arg	Ser	Leu	Gly	Lys	Barré et al., 2014
Glutathione synthetase	P48637	287-301	ER+SHAAKCPDIATQL	N	MS	-	-	Glu	Arg	Ser	His	Ala	Ala	Barré et al., 2014
Glyceraldehyde-3-phosphate dehydrogenase	P04406	199-223	peptide-Arg200+Gly-peptide	N	MS	-	-	Gly	Arg	Gly	Ala	Leu	Gln	Barré et al., 2014
Granulins	Q540U8	203-229	peptide-Arg212+Ser-peptide	N	MS	Pro	Asp	Ala	Arg	Ser	Arg	Cys	Pro	Barré et al., 2014
Heat shock 70 kDa protein 1-like	P34931	357-373	N+GRDLNKSINPDEAVAY	N	MS	-	-	-	Asn	Gly	Arg	Asp	Leu	Barré et al., 2014
Heat shock 70 kDa protein 1A/1B	P08107	87-97	M+KHWPFQVIND	N	MS	-	-	-	Met	Lys	His	Trp	Pro	Barré et al., 2014
Heat shock 70 kDa protein 1A/1B	P08107	526-545	KAEDEVQRER+VSAKNALESY	N	MS	Gln	Arg	Glu	Arg	Val	Ser	Ala	Lys	Barré et al., 2014
Heat shock 70 kDa protein 4	P34932	42-67	peptide-Arg46+Ser-peptide	N	MS	Pro	Lys	Asn	Arg	Ser	Ile	Gly	Ala	Barré et al., 2014
Helicase ARIP4	Q9Y4B4	756-769	FLGK+REVPCPPGTE	N	MS	Phe	Leu	Gly	Lys	Arg	Glu	Val	Pro	Barré et al., 2014
heparin cofactor 2	P05546	20-499	peptide-Leu463+Ser-peptide	P		Phe	Met	Pro	Leu	Ser	Thr	Gln	Val	Szabo et al., 2005	24041
Heterogeneous nuclear ribonucleoprotein D0	Q9UCE8	132-147	PITGR+SRGFGFVLFKE	N	MS	Ile	Thr	Gly	Arg	Ser	Arg	Gly	Phe	Barré et al., 2014
Heterogeneous nuclear ribonucleoprotein D0	Q9UCE8	7-97	peptide-Arg85+His-peptide	N	MS	Ser	Ser	Pro	Arg	His	Ser	Glu	Ala	Barré et al., 2014
Heterogeneous nuclear ribonucleoprotein U	Q00839	600-613	QR+KAVVVCPKDEDY	N	MS	-	-	Gln	Arg	Lys	Ala	Val	Val	Barré et al., 2014
Heterogeneous nuclear ribonucleoproteins A2/B1	P22626	210-227	GDSR+GGGGNFGPGPGSNF	N	MS	Gly	Asp	Ser	Arg	Gly	Gly	Gly	Gly	Barré et al., 2014
Heterogeneous nuclear ribonucleoproteins C1/C2	Q86U45	58-80	peptide-Arg64+Ala-peptide	N	MS	Arg	Asn	Ala	Arg	Ala	Ala	Val	Ala	Barré et al., 2014
Histone H1.2	P16403	17-42	peptide-Arg33+Lys-peptide	N	MS	Gly	Thr	Pro	Arg	Lys	Ala	Ser	Gly	Barré et al., 2014
Histone H1.4	P10412	17-42	peptide-Arg25+Lys-peptide	N	MS	Lys	Lys	Ala	Arg	Lys	Ser	Ala	Gly	Barré et al., 2014
Histone H2A type 1-B/E	P04908	74-93	NKKTRIIPR+HLQLAIRNDEE	N	MS	Ile	Ile	Pro	Arg	His	Leu	Gln	Leu	Barré et al., 2014
Histone H2A type 1-B/E	P04908	94-122	peptide-Ala104+Gln-peptide	N	MS	Val	Thr	Ile	Ala	Gln	Gly	Gly	Val	Barré et al., 2014
Histone H2B type 1-N	Q99877	108-122	AK+HAVSEGTKAVTKY	N	MS	-	-	Ala	Lys	His	Ala	Val	Ser	Barré et al., 2014
Histone H2B type 2-E	Q16778	72-81	ER+IAGEASRL	N	MS	-	-	Glu	Arg	Ile	Ala	Gly	Glu	Barré et al., 2014
Histone H3.2	Q71DI3	2-21	ARTKQTAR+KSTGGKAPRKQL	N	MS	Gln	Thr	Ala	Arg	Lys	Ser	Thr	Gly	Barré et al., 2014
Histone-binding protein RBBP7	Q16576	256-274	TR+SNTTSKPSHLVDAHTAE	N	MS	-	-	Thr	Arg	Ser	Asn	Thr	Thr	Barré et al., 2014
Immunity-related GTPase family Q protein	Q8WZA9	567-607	peptide-His598+Gly-peptide	N	MS	Arg	Ala	Ala	His	Gly	Val	Leu	Leu	Barré et al., 2014
Islet cell autoantigen 1	Q05084	357-375	GPVA+GTPEPEGADKDDLLL	N	MS	Gly	Pro	Val	Ala	Gly	Thr	Pro	Glu	Barré et al., 2014
Keratin, type II cytoskeletal 8	Q6DHW5	453-483	peptide-Arg469+Asp-peptide	N	MS	Ile	Glu	Thr	Arg	Asp	Gly	Lys	Leu	Barré et al., 2014
KH domain-containing, RNA-binding, signal transduction-associated protein 1	Q07666	280-364	peptide-Arg348+Thr-peptide	N	MS	Pro	Arg	Ala	Arg	Thr	Ala	Gly	Ile	Barré et al., 2014
Kinesin-like protein KIF19	Q2TAC6	79-90	MVYQ+ATTKSLIE	N	MS	Met	Val	Tyr	Gln	Ala	Thr	Thr	Lys	Barré et al., 2014
La-related protein 1	Q6PKG0	147-181	peptide-Arg162+Lys-peptide	N	MS	Pro	Lys	Gln	Arg	Lys	Gly	Ser	Lys	Barré et al., 2014
Lamin-B1	P20700	89-99	AR+RALDDTARE	N	MS	-	-	Ala	Arg	Arg	Ala	Leu	Asp	Barré et al., 2014
Mediator of DNA damage checkpoint protein 1	Q2TAZ4	588-610	peptide-Arg596+Lys-peptide	N	MS	Ala	Asp	Val	Arg	Lys	Ser	Gln	Leu	Barré et al., 2014
Mitochondrial antiviral-signaling protein	Q86VY7	231-254	peptide-Arg236+Ala-peptide	N	MS	Ser	Thr	Pro	Arg	Ala	Ser	Arg	Leu	Barré et al., 2014
Mitochondrial import receptor subunit TOM70	O94826	78-106	peptide-Arg89+Ala-peptide	N	MS	Pro	Glu	Gly	Arg	Ala	Ser	Pro	Ala	Barré et al., 2014
Myosin light chain kinase 3	Q32MK0	498-513	EHRVVSV+KETSISAGY	N	MS	Val	Val	Ser	Val	Lys	Glu	Thr	Ser	Barré et al., 2014
N-acetyl-D-glucosamine kinase	Q9UJ70	32-47	GLSTNH+WLIGTDKCVE	N	MS	Ser	Thr	Asn	His	Trp	Leu	Ile	Gly	Barré et al., 2014
Nesprin-1	Q8NF91-4	5681-5700	SLKPKVQAVQLCQ+SALRIPE	N	MS	Gln	Leu	Cys	Gln	Ser	Ala	Leu	Arg	Barré et al., 2014
Nuclear autoantigenic sperm protein	Q96A69	683-715	peptide-Arg697+Lys-peptide	N	MS	Ile	Ala	Ser	Arg	Lys	Pro	Thr	Asp	Barré et al., 2014
Nuclear migration protein nudC	Q9Y266	28-48	LVNTFFSFLR+RKTDFFIGGEE	N	MS	Ser	Phe	Leu	Arg	Arg	Lys	Thr	Asp	Barré et al., 2014
Nucleolin	P19338	593-612	DGSVRAR+IVTDRETGSSKGF	N	MS	Val	Arg	Ala	Arg	Ile	Val	Thr	Asp	Barré et al., 2014
Peptidyl-prolyl cis-trans isomerase A	Q9UC61	68-79	TR+HNGTGGKSIY	N	MS	-	-	Thr	Arg	His	Asn	Gly	Thr	Barré et al., 2014
Peroxiredoxin-1	Q06830	156-171	TLR+LVQAFQFTDKHGE	N	MS	-	Thr	Leu	Arg	Leu	Val	Gln	Ala	Barré et al., 2014
Peroxiredoxin-2	P32119	87-103	INTPR+KEGGLGPLNIPL	N	MS	Asn	Thr	Pro	Arg	Lys	Glu	Gly	Gly	Barré et al., 2014
Peroxisomal membrane protein PEX14	O75381	344-364	GVQREDR+RGGDGQINEQVEKL	N	MS	Arg	Glu	Asp	Arg	Arg	Gly	Gly	Asp	Barré et al., 2014
Phosphatidylserine synthase 2	Q9BVG9	159-167	P+KLGVPLPE	N	MS	-	-	-	Pro	Lys	Leu	Gly	Val	Barré et al., 2014
Phytanoyl-CoA hydroxylase-interacting protein-like	Q96FC7	161-171	YSK+VHLTQLLE	N	MS	-	Tyr	Ser	Lys	Val	His	Leu	Thr	Barré et al., 2014
plasma serine protease inhibitor	P05154	20-406	peptide-Arg+Ser-peptide	P		Phe	Thr	Phe	Arg	Ser	Ala	Arg	Leu	Szabo et al., 2005	24040
plasminogen activator inhibitor-1	P05121	24-402	peptide-Arg+Met-peptide	P		Val	Ser	Ala	Arg	Met	Ala	Pro	Glu	Szabo et al., 2005	24038
Programmed cell death protein 5	O14737	50-65	QSAR+ARLSNLALVKPE	N	MS	Gln	Ser	Ala	Arg	Ala	Arg	Leu	Ser	Barré et al., 2014
Proteasome subunit alpha type-3	P25788	163-180	GCAIGKAR+QAAKTEIEKL	N	MS	Gly	Lys	Ala	Arg	Gln	Ala	Ala	Lys	Barré et al., 2014
Protein phosphatase 1F	P49593	421-454	peptide-Arg435+Arg-peptide	N	MS	Ala	Glu	Gly	Arg	Arg	Gln	Asp	Leu	Barré et al., 2014
Putative ATP-dependent RNA helicase DHX57	Q6P158	1187-1201	KRAQG+GDGVLDATGE	N	MS	Arg	Ala	Gln	Gly	Gly	Asp	Gly	Val	Barré et al., 2014
Ribonuclease UK114	P52758	95-122	peptide-Arg107+Ala-peptide	N	MS	Phe	Pro	Ala	Arg	Ala	Ala	Tyr	Gln	Barré et al., 2014
snRNA-activating protein complex subunit 2	Q13487	2-17	KPPPRRR+AAPARYLGE	N	MS	Pro	Arg	Arg	Arg	Ala	Ala	Pro	Ala	Barré et al., 2014
Spermidine synthase	P19623	82-110	peptide-Arg95+Lys-peptide	N	MS	Pro	Asn	Pro	Arg	Lys	Val	Leu	Ile	Barré et al., 2014
Splicing factor, arginine/serine-rich 15	O95104	490-501	RRQ+KGLPQVKPE	N	MS	-	Arg	Arg	Gln	Lys	Gly	Leu	Pro	Barré et al., 2014
Staphylococcal nuclease domain-containing protein 1	Q7KZF4	60-78	AR+RAAATQPDAKDTPDEPW	N	MS	-	-	Ala	Arg	Arg	Ala	Ala	Ala	Barré et al., 2014
Suc-Ala-Ala-Pro-Arg-NHPhNO2			Suc-Ala-Ala-Pro-Arg+NHPhNO2	S		Ala	Ala	Pro	Arg	NAN	-	-	-	Szabo et al., 2005
Symplekin	Q92797	560-573	AM+KLGAVKRILRAE	N	MS	-	-	Ala	Met	Lys	Leu	Gly	Ala	Barré et al., 2014
Syntaxin-10	O60499	139-150	ASAVS+ATSRYIE	N	MS	Ser	Ala	Val	Ser	Ala	Thr	Ser	Arg	Barré et al., 2014
T-complex protein 1 subunit delta	P50991	525-539	TVR+SILKIDDVVNTR	N	MS	-	Thr	Val	Arg	Ser	Ile	Leu	Lys	Barré et al., 2014
T-complex protein 1 subunit delta	P50991	2-24	peptide-Arg8+Ser-peptide	N	MS	Val	Ala	Pro	Arg	Ser	Gly	Ala	Thr	Barré et al., 2014
TATA-binding protein-associated factor 2N	Q92804	358-385	peptide-Arg372+Arg-peptide	N	MS	Asn	Phe	Ala	Arg	Arg	Asn	Ser	Cys	Barré et al., 2014
Titin	Q8WZ42-2	12706-12727	peptide-Thr12718+Ala-peptide	N	MS	Gln	Pro	Leu	Thr	Ala	Ser	Pro	Asp	Barré et al., 2014
Tropomyosin alpha-4 chain	Q9UCS3	36-52	DGERER+REKAEGDVAAL	N	MS	Glu	Arg	Glu	Arg	Arg	Glu	Lys	Ala	Barré et al., 2014
Tyrosine--tRNA ligase, cytoplasmic	P54577	369-388	DIRVGKIITVE+KHPDADSLY	N	MS	Ile	Thr	Val	Glu	Lys	His	Pro	Asp	Barré et al., 2014
U6 snRNA-associated Sm-like protein LSm2	Q9Y333	83-95	QDAAR+KEALQQKQ	N	MS	Asp	Ala	Ala	Arg	Lys	Glu	Ala	Leu	Barré et al., 2014
UMP-CMP kinase	P30085	39-56	RDER+KNPDSQYGELIEKY	N	MS	Arg	Asp	Glu	Arg	Lys	Asn	Pro	Asp	Barré et al., 2014
Unconventional myosin-Va	Q9Y4I1	974-995	peptide-Thr982+Gly-peptide	N	MS	Lys	Val	Ala	Thr	Gly	Arg	Val	Leu	Barré et al., 2014
Vimentin	Q8N850	444-466	peptide-Arg450+Asp-peptide	N	MS	Val	Glu	Thr	Arg	Asp	Gly	Gln	Val	Barré et al., 2014
Z-Phe-Val-Arg-NHPhNO2			Z-Phe-Val-Arg+NHPhNO2	S		Z	Phe	Val	Arg	NAN	-	-	-	Szabo et al., 2005