Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P26373

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-211	P		NT	<%Agarwal et al., 2012[]%>
21	trypsin 1	2-211	N		MS	Schilling & Overall, 2008
31	trypsin 1	2-211	N		MS	Schilling & Overall, 2008
50	matrix metallopeptidase-2	45-60	N		MS	Schilling & Overall, 2008
60	trypsin 1	2-211	N		MS	Schilling & Overall, 2008
74	trypsin 1	2-211	N		MS	Schilling & Overall, 2008
82	trypsin 1	2-211	N		MS	Schilling & Overall, 2008
105	granzyme A	1-211	N			Van Damme et al., 2010
105	trypsin 1	2-211	N		MS	Schilling & Overall, 2008
116	trypsin 1	2-211	N		MS	Schilling & Overall, 2008
141	meprin beta subunit	2-211	N		MS	Becker-Pauly et al., 2011
145	trypsin 1	2-211	N		MS	Schilling & Overall, 2008
149	cathepsin B	146-158	N		MS	Biniossek et al., 2011
149	matrix metallopeptidase-2	145-158	N		MS	Schilling & Overall, 2008
158	trypsin 1	2-211	N		MS	Schilling & Overall, 2008