Peptide and protein substrates that are thought to be physiologically relevant are indicated by P.
Peptide and protein substrates that are not physiologically relevant are indicated by N.
How cleavage sites have been identified are indicated by the following evidence codes:
NT = N-terminal sequencing,
MS = mass spectroscopy,
MU = mutation,
CS = consensus sequence,
LC = liquid chromatography.
To see all annotated cleavages for a peptidase, click on the peptidase name.
| Cleavage Site |
Peptidase |
Residue range |
Cleavage type |
Description |
Evidence |
Reference |
|---|
| 1 |
unknown peptidase |
1-2647 |
P |
|
NT |
<%Agarwal et al., 2012[]%> |
| 7 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 24 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 28 |
meprin alpha subunit |
2-2647 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 28 |
meprin beta subunit |
2-2647 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 216 |
meprin beta subunit |
213-226 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 302 |
meprin alpha subunit |
2-2647 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 309 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 319 |
HIV-1 retropepsin |
309-331 |
N |
|
MS |
Schilling & Overall, 2008 |
| 331 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 383 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 387 |
astacin |
384-400 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 400 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 580 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 582 |
meprin alpha subunit |
579-593 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 593 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 643 |
HIV-1 retropepsin |
634-655 |
N |
|
MS |
Schilling & Overall, 2008 |
| 655 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 686 |
meprin alpha subunit |
2-647 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 688 |
meprin alpha subunit |
2-2647 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 693 |
meprin beta subunit |
2-2647 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 936 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 958 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 973 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 975 |
lysyl endopeptidase (bacteria) |
1-2647 |
N |
|
MS |
|
| 1007 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1017 |
matrix metallopeptidase-2 |
1007-1032 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1019 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1032 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1038 |
glutamyl endopeptidase I |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1048 |
unknown peptidase |
|
P |
|
MS |
Mahrus et al., 2008 |
| 1058 |
matrix metallopeptidase-2 |
1036-1069 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1069 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1071 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1087 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1139 |
HIV-1 retropepsin |
1093-1151 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1140 |
LAST_MAM peptidase (Limulus-type) |
1136-1151 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 1151 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1153 |
meprin alpha subunit |
2-2647 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 1234 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1246 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1272 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1283 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1336 |
unknown peptidase |
|
P |
|
MS |
Mahrus et al., 2008 |
| 1366 |
matrix metallopeptidase-2 |
1359-1375 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1367 |
meprin alpha subunit |
2-2647 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 1367 |
meprin beta subunit |
2-2647 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 1375 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1381 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1399 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1438 |
cathepsin G |
1406-1450 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1443 |
meprin alpha subunit |
2-2647 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 1443 |
meprin beta subunit |
2-2647 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 1450 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1464 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1477 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1491 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1504 |
unknown peptidase |
|
P |
|
MS |
Mahrus et al., 2008 |
| 1515 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1549 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1573 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1761 |
calpain-2 |
2-2647 |
N |
|
|
|
| 1814 |
trypsin 1 |
1-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1831 |
trypsin 1 |
1-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1836 |
astacin |
1833-1845 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 1964 |
trypsin 1 |
1-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1993 |
trypsin 1 |
1-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2276 |
LAST_MAM peptidase (Limulus-type) |
2273-2289 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 2484 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2500 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2540 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2545 |
matrix metallopeptidase-2 |
2540-2559 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2547 |
LAST peptidase (Limulus-type) |
2544-2559 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 2559 |
trypsin 1 |
2-2647 |
N |
|
MS |
Schilling & Overall, 2008 |
