Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence Q07666

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
17	granzyme A	1-443	N			Van Damme et al., 2010
21	meprin beta subunit	18-31	N		MS	Becker-Pauly et al., 2011
75	unknown peptidase	1-443	P		MS	Dix et al., 2008
102	trypsin 1	1-443	N		MS	Schilling & Overall, 2008
111	trypsin 1	1-443	N		MS	Schilling & Overall, 2008
131	trypsin 1	1-443	N		MS	Schilling & Overall, 2008
140	meprin alpha subunit	1-443	N		MS	Becker-Pauly et al., 2011
140	meprin beta subunit	1-443	N		MS	Becker-Pauly et al., 2011
141	LAST_MAM peptidase (Limulus-type)	138-152	N		MS	Becker-Pauly et al., 2011
177	cathepsin L	166-186	N		MS	Biniossek et al., 2011
414	meprin alpha subunit	411-424	N		MS	Becker-Pauly et al., 2011
414	meprin beta subunit	410-424	N		MS	Becker-Pauly et al., 2011