Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence Q92945

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-710	P	release of an initiating methionine	MS
24	cathepsin B	1-40	N		MS	Biniossek et al., 2011
72	caspase-3	1-711	P		CS	Thiede et al., 2001
76	caspase-3	1-711	P		CS	Thiede et al., 2001
87	trypsin 1	1-710	N		MS	Schilling & Overall, 2008
91	caspase-3	1-711	P		CS	Thiede et al., 2001
91	granzyme B (Homo sapiens-type)	1-711	N		MS	Van Damme et al., 2010
98	meprin beta subunit	95-110	N		MS	Becker-Pauly et al., 2011
99	meprin alpha subunit	96-110	N		MS	Becker-Pauly et al., 2011
102	caspase-3	1-711	P		CS	Thiede et al., 2001
102	meprin alpha subunit	99-110	N		MS	Becker-Pauly et al., 2011
109	trypsin 1	1-710	N		MS	Schilling & Overall, 2008
114	caspase-3	1-711	P		CS	Thiede et al., 2001
116	caspase-3	1-711	P		CS	Thiede et al., 2001
122	trypsin 1	1-710	N		MS	Schilling & Overall, 2008
127	meprin beta subunit	124-142	N		MS	Becker-Pauly et al., 2011
128	caspase-1	1-711	N		MS	Agard et al., 2010
128	caspase-3	1-711	P		CS	Thiede et al., 2001
131	cathepsin L	123-142	N		MS	Biniossek et al., 2011
131	cathepsin S	123-142	N		MS	Biniossek et al., 2011
133	cathepsin B	122-143	N		MS	Biniossek et al., 2011
133	meprin alpha subunit	130-142	N		MS	Becker-Pauly et al., 2011
142	trypsin 1	1-710	N		MS	Schilling & Overall, 2008
150	trypsin 1	1-710	N		MS	Schilling & Overall, 2008
162	trypsin 1	1-710	N		MS	Schilling & Overall, 2008
173	granzyme B (Homo sapiens-type)	1-711	N		MS	Van Damme et al., 2010
183	granzyme B (Homo sapiens-type)	1-711	N		MS	Van Damme et al., 2010
190	trypsin 1	1-710	N		MS	Schilling & Overall, 2008
193	cathepsin B	191-203	N		MS	Biniossek et al., 2011
195	cathepsin L	191-203	N		MS	Biniossek et al., 2011
203	trypsin 1	1-710	N		MS	Schilling & Overall, 2008
205	trypsin 1	1-710	N		MS	Schilling & Overall, 2008
214	trypsin 1	1-710	N		MS	Schilling & Overall, 2008
232	astacin	229-244	N		MS	Becker-Pauly et al., 2011
266	trypsin 1	1-710	N		MS	Schilling & Overall, 2008
267	cathepsin B	267-284	N		MS	Biniossek et al., 2011
269	cathepsin L	267-284	N		MS	Biniossek et al., 2011
270	cathepsin L	267-285	N		MS	Biniossek et al., 2011
271	cathepsin L	267-284	N		MS	Biniossek et al., 2011
271	cathepsin S	267-284	N		MS	Biniossek et al., 2011
271	cathepsin B	267-284	N		MS	Biniossek et al., 2011
272	cathepsin B	267-284	N		MS	Biniossek et al., 2011
284	trypsin 1	1-710	N		MS	Schilling & Overall, 2008
291	trypsin 1	1-710	N		MS	Schilling & Overall, 2008
384	trypsin 1	1-710	N		MS	Schilling & Overall, 2008
394	trypsin 1	1-710	N		MS	Schilling & Overall, 2008
478	cathepsin L	463-488	N		MS	Biniossek et al., 2011
548	cathepsin L	495-564	N		MS	Biniossek et al., 2011
553	cathepsin L	495-564	N		MS	Biniossek et al., 2011
554	LAST_MAM peptidase (Limulus-type)	551-564	N		MS	Becker-Pauly et al., 2011
620	trypsin 1	1-710	N		MS	Schilling & Overall, 2008
627	trypsin 1	1-710	N		MS	Schilling & Overall, 2008
628	trypsin 1	1-710	N		MS	Schilling & Overall, 2008
630	cathepsin S	629-645	N		MS	Biniossek et al., 2011
637	astacin	634-646	N		MS	Becker-Pauly et al., 2011
646	trypsin 1	1-710	N		MS	Schilling & Overall, 2008