Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P08697

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
27	unknown peptidase	1-491	P	release of a signal peptide	NT	Christensen & Sottrup-Jensen, 1992
30	fibroblast activation protein alpha subunit	40-491	P		MS	Lee et al., 2006
39	fibroblast activation protein alpha subunit	1-491	P		MS	Lee et al., 2006
46	matrix metallopeptidase-3	40-491	P	release of an activation peptide		Nagase, 2004
51	aureolysin	40-491	N			Beaufort et al., 2008
395	matrix metallopeptidase-11	40-491	P			Pei et al., 1994
397	matrix metallopeptidase-11	40-491	P			Pei et al., 1994
398	aureolysin	40-491	N			Beaufort et al., 2008
400	elastase-2	40-491	P			Shieh & Travis, 1987
401	matrix metallopeptidase-3	40-491	P	normal turnover		Nagase, 2004
401	chymotrypsin A (cattle-type)	40-491	P			Enghild et al., 1993
403	matriptase-3	40-491	P			Szabo et al., 2005
403	elastase-2	40-491	P			Shieh & Travis, 1987
403	trypsin 1	40-491	P			Enghild et al., 1993
403	plasmin	24-402	P			Holmes et al., 1987
403	glutamyl endopeptidase I	40-491	P			Shieh & Travis, 1987
404	chymotrypsin A (cattle-type)	40-491	P			Enghild et al., 1993
443	matrix metallopeptidase-3	40-491	P	normal turnover		Nagase, 2004
459	matrix metallopeptidase-3	40-491	P	normal turnover		Nagase, 2004