Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P52907

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-286	P		NT	<%Agarwal et al., 2012[]%>
35	caspase-6	2-286	P		MS	Klaiman et al., 2008
106	meprin alpha subunit	2-286	N		MS	Becker-Pauly et al., 2011
106	meprin beta subunit	2-286	N		MS	Becker-Pauly et al., 2011
114	caspase-6	2-286	P		MS	Klaiman et al., 2008
157	HIV-1 retropepsin	146-166	N		MS	Schilling & Overall, 2008
166	trypsin 1	2-286	N		MS	Schilling & Overall, 2008
178	trypsin 1	2-286	N		MS	Schilling & Overall, 2008
193	trypsin 1	2-286	N		MS	Schilling & Overall, 2008
210	trypsin 1	2-286	N		MS	Schilling & Overall, 2008
226	trypsin 1	2-286	N		MS	Schilling & Overall, 2008
230	trypsin 1	2-286	N		MS	Schilling & Overall, 2008
256	trypsin 1	2-286	N		MS	Schilling & Overall, 2008