Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P05121

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
23	unknown peptidase	1-402	P		NT	<%Agarwal et al., 2012[]%>
359	matrix metallopeptidase-3	24-402	P	normal turnover		Nagase, 2004
360	matrix metallopeptidase-3	1-402	P			Lijnen et al., 2000
364	matrix metallopeptidase-3	24-402	P	normal turnover		Lijnen et al., 2000
369	plasminogen activator Pla	24-402	P		NT	Haiko et al., 2010
369	protein E (Salmonella sp.)	24-402	P		NT	Haiko et al., 2010
369	matriptase-3	24-402	P			Szabo et al., 2005
369	kallikrein-related peptidase 2	24-402	P			Mikolajczyk et al., 1999
369	t-plasminogen activator	24-402	P	springing of a trap mechanism	NT	Declerck et al., 1992