Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P01008

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
32	unknown peptidase	1-464	P	release of a signal peptide	NT
422	staphopain C	33-464	N		NT	Wladyka et al., 2011
422	elastase-2	33-464	P	normal turnover		Chang et al., 1996
423	staphopain C	33-464	N		NT	Wladyka et al., 2011
425	matrix metallopeptidase-3	33-464	P	springing of a trap mechanism		Mast et al., 1991
425	matriptase-3	33-464	P			Szabo et al., 2005
425	thrombin	33-464	P	springing of a trap mechanism		Björk et al., 1981
426	thermolysin	33-464	N			Chang et al., 1996