Literature for peptidase S01.017: kallikrein-related peptidase 5

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Zingkou,E., Bisyris,E., Pampalakis,G. and Sotiropoulou,G. Dysregulated proteolytic cascades in Netherton syndrome: from molecular pathology to preclinical drug testing J Pathol (2026) PubMed Europe PubMed DOI

2025

Palacios Serrato,E.G., Medina-Abreu,K.H., Oropeza-Martinez,E., Jacinto-Aleman,L.F., Macias-Silva,M. and Tecalco-Cruz,A.C. ADAMTS-8 and kallikrein-related peptidases 10 and 5 proteases also have a tumor suppression role World J Clin Oncol (2025) 16, 110202-110202. PubMed Europe PubMed DOI PMC EPMC
Zingkou,E., Reynier,M., Pampalakis,G., Serre,G., Jonca,N. and Sotiropoulou,G. Deletion of the Epidermal Protease KLK5 Aggravates the Symptoms of Congenital Ichthyosis CDSN-nEDD Int J Mol Sci (2025) 26 PubMed Europe PubMed DOI PMC EPMC K

2024

Kim,H., Kang,Y., Kim,S., Park,D., Heo,S.Y., Yoo,J.S., Choi,I., N,M.P.A., Ahn,J.W., Yang,J.S., Bak,N., Kim,K.K., Lee,J.Y. and Choi,Y.K. The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation Sci Signal (2024) 17, eadn3785-eadn3785. PubMed Europe PubMed DOI

2023

Stuardo-Parada,A., Lopez-Munoz,R., Villarroel-Espindola,F., Figueroa,C.D. and Ehrenfeld,P. Minireview: functional roles of tissue kallikrein, kinins, and kallikrein-related peptidases in lung cancer Med Oncol (2023) 40, 224-224. PubMed Europe PubMed DOI V

2022

Gonschorek,P., Zorzi,A., Maric,T., Le Jeune,M., Schuttel,M., Montagnon,M., Gomez-Ojea,R., Vollmar,D.P., Whitfield,C., Reymond,L., Carle,V., Verma,H., Schilling,O., Hovnanian,A. and Heinis,C. Phage Display Selected Cyclic Peptide Inhibitors of Kallikrein-Related Peptidases 5 and 7 and Their In Vivo Delivery to the Skin J Med Chem (2022) 65, 9735-9749. PubMed Europe PubMed DOI
Jackman,J.K., Stockwell,A., Choy,D.F., Xie,M.M., Lu,P., Jia,G., Li,H., Abbas,A.R., Bronson,P.G., Lin,W.Y., Chiu,C.P.C., Maun,H.R., Roose-Girma,M., Tam,L., Zhang,J., Modrusan,Z., Graham,R.R., Behrens,T.W., White,S.R., Naureckas,T., Ober,C., Ferreira,M., Sedlacek,R., Wu,J., Lee,W.P., Lazarus,R.A., Koerber,J.T., Arron,J.R., Yaspan,B.L. and Yi,T. Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma J Allergy Clin Immunol (2022) 150, 972-978. PubMed Europe PubMed DOI
Zhou,S., Liu,S., Tian,G., Zhao,L., Wang,H., Li,Y., Shen,Y. and Han,L. KLK5 is associated with the radioresistance, aggression, and progression of cervical cancer Gynecol Oncol (2022) 166, 138-147. PubMed Europe PubMed DOI
Zingkou,E., Pampalakis,G. and Sotiropoulou,G. Cocktails of KLK5 Protease Inhibitors and Anti-TNFalpha Therapeutics: an Effective Treatment for Netherton Syndrome J Clin Immunol (2022) PubMed Europe PubMed DOI

2021

Almaraz-Giron,M.A., Calderon-Jaimes,E., Carrillo,A.S., Diaz-Cervantes,E., Alonso,E.C., Islas-Jacome,A., Dominguez-Ortiz,A. and Castanon-Alonso,S.L. Search for Non-Protein Protease Inhibitors Constituted with an Indole and Acetylene Core Molecules (2021) 26 PubMed Europe PubMed DOI PMC EPMC
Kim,J., Kim,M.G., Jeong,S.H., Kim,H.J. and Son,S.W. STAT3 maintains skin barrier integrity by modulating SPINK5 and KLK5 expression in keratinocytes Exp Dermatol (2021) PubMed Europe PubMed DOI K
Lavergne,M., Guillon-Munos,A., Lenga Ma Bonda,W., Attucci,S., Kryza,T., Barascu,A., Moreau,T., Petit-Court, Sizaret,D., Courty,Y., Iochmann,S. and Reverdiau,P. Tissue factor pathway inhibitor 2 is a potent kallikrein-related protease 12 inhibitor Biol Chem (2021) PubMed Europe PubMed DOI
Lenga Ma Bonda,W., Lavergne,M., Vasseur,V., Brisson,L., Roger,S., Legras,A., Guillon,A., Guyetant,S., Hiemstra,P.S., Si-Tahar,M., Iochmann,S. and Reverdiau,P. Kallikrein-related peptidase 5 contributes to the remodeling and repair of bronchial epithelium FASEB J (2021) 35, e21838-e21838. PubMed Europe PubMed DOI K
Zani,M.B., Sant'Ana,A.M., Tognato,R.C., Chagas,J.R. and Puzer,L. Human Tissue Kallikreins-Related Peptidases Are Targets for the Treatment of Skin Desquamation Diseases Front Med (Lausanne) (2021) 8, 777619-777619. PubMed Europe PubMed DOI PMC EPMC V

2020

Alves,M.G., Kodama,M.H., da Silva,E.Z.M., Gomes,B.B.M., da Silva,R.A.A., Vieira,G.V., Alves,V.M., da Fonseca,C.K., Santana,A.C., Cecilio,N.T., Costa,M.S.A., Jamur,M.C., Oliver,C., Cunha,T.M., Bugge,T.H., Braz-Silva,P.H., Colli,L.M. and Sales,K.U. Relative expression of KLK5 to LEKTI is associated with aggressiveness of oral squamous cell carcinoma Transl Oncol (2020) 14, 100970-100970. PubMed Europe PubMed DOI PMC EPMC
Azouz,N.P., Klingler,A.M., Pathre,P., Besse,J.A., Baruch-Morgenstern,N.B., Ballaban,A.Y., Osswald,G.A., Brusilovsky,M., Habel,J.E., Caldwell,J.M., Ynga-Durand,M.A., Abonia,P.J., Hu,Y.C., Wen,T. and Rothenberg,M.E. Functional role of kallikrein 5 and proteinase-activated receptor 2 in eosinophilic esophagitis Sci Transl Med (2020) 12 PubMed Europe PubMed DOI
Chang,J.S., Kim,N., Kim,J.Y., Do,S.I., Cho,Y., Kim,H.S. and Kim,Y.B. Kallikrein 5 overexpression is associated with poor prognosis in uterine cervical cancer J Gynecol Oncol (2020) 31, e78-e78. PubMed Europe PubMed DOI
Fukagawa,S., Takahashi,A., Sayama,K., Mori,S. and Murase,T. Carbon dioxide ameliorates reduced desquamation in dry scaly skin via protease activation Int J Cosmet Sci (2020) PubMed Europe PubMed DOI
Zingkou,E., Pampalakis,G. and Sotiropoulou,G. Exacerbated dandruff in the absence of kallikrein-related peptidase 5 protease J Dermatol (2020) 47, 311-313. PubMed Europe PubMed DOI

2019

Di Paolo,C.T., Filippou,P.S., Yu,Y., Poda,G., Diamandis,E.P. and Prassas,I. Screening of chemical libraries in pursuit of kallikrein-5 specific inhibitors for the treatment of inflammatory dermatoses Clin Chem Lab Med (2019) 57, 1737-1743. PubMed Europe PubMed DOI I
Pampalakis,G., Zingkou,E., Kaklamanis,L., Spella,M., Stathopoulos,G.T. and Sotiropoulou,G. Elimination of KLK5 inhibits early skin tumorigenesis by reducing epidermal proteolysis and reinforcing epidermal microstructure Biochim Biophys Acta Mol Basis Dis (2019) 1865, 165520-165520. PubMed Europe PubMed DOI K
Thorpe,J.H., Edgar,E.V., Smith,K.J., Lewell,X.Q., Rella,M., White,G.V., Polyakova,O., Nassau,P., Walker,A.L., Holmes,D.S., Pearce,A.C., Wang,Y., Liddle,J. and Hovnanian,A. Evaluation of a crystallographic surrogate for kallikrein 5 in the discovery of novel inhibitors for Netherton syndrome Acta Crystallogr F Struct Biol Commun (2019) 75, 385-391. PubMed Europe PubMed DOI S
Walker,A.L., Bingham,R.P., Edgar,E.V., Ferrie,A., Holmes,D.S., Liddle,J., Polyakova,O., Rella,M., Smith,K.J., Thorpe,J.H., Wang,Y., White,G.V., Young,R.J. and Hovnanian,A. Structure guided drug design to develop kallikrein 5 inhibitors to treat Netherton syndrome Bioorg Med Chem Lett (2019) 29, 1454-1458. PubMed Europe PubMed DOI I
Walker,A.L., Denis,A., Bingham,R.P., Boulliot,A., Edgar,E.V., Ferrie,A., Holmes,D.S., Laroze,A., Liddle,J., Fouchet,M.H., Moquette,A., Nassau,P., Pearce,A.C., Polyakova,O., Smith,K.J., Thomas,P., Thorpe,J.H., Trottet,L., Wang,Y. and Hovnanian,A. Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors Bioorg Med Chem Lett (2019) 29, 126675-126675. PubMed Europe PubMed DOI I
White,G.V., Edgar,E.V., Holmes,D.S., Lewell,X.Q., Liddle,J., Polyakova,O., Smith,K.J., Thorpe,J.H., Walker,A.L., Wang,Y., Young,R.J. and Hovnanian,A. Kallikrein 5 inhibitors identified through structure based drug design in search for a treatment for Netherton Syndrome Bioorg Med Chem Lett (2019) 29, 821-825. PubMed Europe PubMed DOI M I

2018

Grunberg,M., Quandt,D., Cynis,H., Demuth,H.U., Kindermann,A., Magdolen,V., Forssmann,W.G., Seliger,B. and Magert,H.J. Kallikrein-related peptidases are activators of the CC chemokine CCL14 Eur J Immunol (2018) 48, 1592-1594. PubMed Europe PubMed DOI
Horn,M., Zbodakova,O., Kasparek,P., Srp,J., Haneckova,R., Hradilek,M., Mares,M. and Sedlacek,R. Profiling system for skin kallikrein proteolysis applied in gene-deficient mouse models Biol Chem (2018) 399, 1085-1089. PubMed Europe PubMed DOI A
Loessner,D., Goettig,P., Preis,S., Felber,J., Bronger,H., Clements,J.A., Dorn,J. and Magdolen,V. Kallikrein-related peptidases represent attractive therapeutic targets for ovarian cancer Expert Opin Ther Targets (2018) 22, 745-763. PubMed Europe PubMed DOI T
Magnen,M., Elsasser,B.M., Zbodakova,O., Kasparek,P., Gueugnon,F., Petit-Courty,A., Sedlacek,R., Goettig,P. and Courty,Y. Kallikrein-related peptidase 5 and seasonal influenza viruses, limitations of the experimental models for activating proteases Biol Chem (2018) 399, 1053-1064. PubMed Europe PubMed DOI

2017

Adamopoulos,P.G., Kontos,C.K. and Scorilas,A. Molecular cloning of novel transcripts of human kallikrein-related peptidases 5, 6, 7, 8 and 9 (KLK5 - KLK9), using Next-generation sequencing Sci Rep (2017) 7, 17299-17299. PubMed Europe PubMed DOI PMC EPMC M
Fang,X., Bagui,S. and Bagui,S. Improving virtual screening predictive accuracy of human kallikrein 5 inhibitors using machine learning models Comput Biol Chem (2017) 69, 110-119. PubMed Europe PubMed DOI I
Kasparek,P., Ileninova,Z., Zbodakova,O., Kanchev,I., Benada,O., Chalupsky,K., Brattsand,M., Beck,I.M. and Sedlacek,R. KLK5 and KLK7 ablation fully rescues lethality of Netherton syndrome-like phenotype PLoS Genet (2017) 13, e1006566-e1006566. PubMed Europe PubMed DOI K
Matsubara,Y., Matsumoto,T., Koseki,J., Kaneko,A., Aiba,S. and Yamasaki,K. Inhibition of human kallikrein 5 protease by triterpenoids from natural sources Molecules (2017) 22 PubMed Europe PubMed DOI I
McGovern,J.A., Meinert,C., deVeer,S.J., Hollier,B.G., Parker,T.J. and Upton,Z. Attenuated kallikrein-related peptidase activity disrupts desquamation and leads to stratum corneum thickening in human skin equivalent models Br J Dermatol (2017) 176, 145-158. PubMed Europe PubMed DOI
Nargis,T., Kumar,K., Ghosh,A.R., Sharma,A., Rudra,D., Sen,D., Chakrabarti,S., Mukhopadhyay,S., Ganguly,D. and Chakrabarti,P. KLK5 induces shedding of DPP4 from circulatory Th17 cells in type 2 diabetes Mol Metab (2017) 6, 1529-1539. PubMed Europe PubMed DOI

2016

Chen,W., Kinsler,V.A., Macmillan,D. and Di,W.L. Tissue kallikrein inhibitors based on the sunflower trypsin inhibitor scaffold - a potential therapeutic intervention for skin diseases PLoS ONE (2016) 11, e0166268-e0166268. PubMed Europe PubMed DOI PMC EPMC
de Veer,S.J., Swedberg,J.E., Brattsand,M., Clements,J.A. and Harris,J.M. Exploring the active site binding specificity of kallikrein-related peptidase 5 (KLK5) guides the design of new peptide substrates and inhibitors Biol Chem (2016) 397, 1237-1249. PubMed Europe PubMed DOI P
Hoelz,L.V., Zorzanelli,B.C., Azevedo,P.H., Passos,S.G., de Souza,L.R., Zani,M., Pinheiro,S., Puzer,L., Dias,L.R. and Muri,E.M. Synthesis, biological evaluation and molecular modeling of pseudo-peptides based statine as inhibitors for human tissue kallikrein 5 Eur J Med Chem (2016) 112, 39-47. PubMed Europe PubMed DOI I
Kalinska,M., Meyer-Hoffert,U., Kantyka,T. and Potempa,J. Kallikreins - the melting pot of activity and function Biochimie (2016) 122, 270-282. PubMed Europe PubMed DOI V
Karakosta,T.D., Soosaipillai,A., Diamandis,E.P., Batruch,I. and Drabovich,A.P. Quantification of human kallikrein-related peptidases in biological fluids by multiplatform targeted mass spectrometry assays Mol Cell Proteomics (2016) 15, 2863-2876. PubMed Europe PubMed DOI A

2015

Severino,B., Fiorino,F., Corvino,A., Caliendo,G., Santagada,V., Assis,D.M., Oliveira,J.R., Juliano,L., Manganelli,S., Benfenati,E., Frecentese,F., Perissutti,E. and Juliano,M.A. Synthesis, biological evaluation, and docking studies of PAR2-AP-derived pseudopeptides as inhibitors of kallikrein 5 and 6 Biol Chem (2015) 396, 45-52. PubMed Europe PubMed DOI I
Tan,X., Soualmia,F., Furio,L., Renard,J.F., Kempen,I., Qin,L., Pagano,M., Pirotte,B., El Amri,C., Hovnanian,A. and Reboud-Ravaux,M. Toward the first class of suicide inhibitors of kallikreins involved in skin diseases J Med Chem (2015) 58, 598-612. PubMed Europe PubMed DOI I

2014

Furio,L., de Veer,S., Jaillet,M., Briot,A., Robin,A., Deraison,C. and Hovnanian,A. Transgenic kallikrein 5 mice reproduce major cutaneous and systemic hallmarks of Netherton syndrome J Exp Med (2014) 211, 499-513. PubMed Europe PubMed DOI
Pampalakis,G., Obasuyi,O., Papadodima,O., Chatziioannou,A., Zoumpourlis,V. and Sotiropoulou,G. The KLK5 protease suppresses breast cancer by repressing the mevalonate pathway Oncotarget (2014) 5, 2390-2403. PubMed Europe PubMed
Shariff,L., Zhu,Y., Cowper,B., Di,W.-L. and Macmillan,D. Sunflower trypsin inhibitor (SFTI-1) analogues of synthetic and biological origin via N-->S acyl transfer: potential inhibitors of human kallikrein-5 (KLK5) Tetrahedron (2014) 70, 7675-7680. DOI
Two,A.M. and Del Rosso,J.Q. Kallikrein 5-mediated inflammation in rosacea: clinically relevant correlations with acute and chronic manifestations in rosacea and how individual treatments may provide therapeutic benefit J Clin Aesthet Dermatol (2014) 7, 20-25. PubMed Europe PubMed PMC EPMC

2013

de Souza,L.R., Melo,M., Paschoalin,T., Carmona,A.K., Kondo,M., Hirata,I.Y., Blaber,M., Tersariol,I., Takatsuka,J., Juliano,M.A., Juliano,L., Gomes,R.A. and Puzer,L. Human tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasmin Biochem Biophys Res Commun (2013) 433, 333-337. PubMed Europe PubMed DOI
Hamilton,B.S. and Whittaker,G.R. Cleavage activation of human-adapted influenza virus subtypes by kallikrein-related peptidases 5 and 12 J Biol Chem (2013) 288, 17399-17407. PubMed Europe PubMed DOI
Lose,F., Batra,J., O'Mara,T., Fahey,P., Marquart,L., Eeles,R.A., Easton,D.F., Al Olama,A.A., Kote-Jarai,Z., Guy,M., Muir,K., Lophatananon,A., Rahman,A.A., Neal,D.E., Hamdy,F.C., Donovan,J.L., Chambers,S., Gardiner,R.A., Aitken,J.F., Yaxley,J., Alexander,K., Clements,J.A., Spurdle,A.B. and Kedda,M.A. Common variation in kallikrein genes KLK5, KLK6, KLK12, and KLK13 and risk of prostate cancer and tumor aggressiveness Urol Oncol (2013) 31, 635-643. PubMed Europe PubMed DOI M
Lundwall,A. Old genes and new genes: The evolution of the kallikrein locus Thromb Haemost (2013) 110, 469-475. PubMed Europe PubMed DOI V
Sakabe,J., Yamamoto,M., Hirakawa,S., Motoyama,A., Ohta,I., Tatsuno,K., Ito,T., Kabashima,K., Hibino,T. and Tokura,Y. Kallikrein-related peptidase 5 functions in proteolytic processing of profilaggrin in cultured human keratinocytes J Biol Chem (2013) 288, 17179-17189. PubMed Europe PubMed DOI
Tan,X., Furio,L., Reboud-Ravaux,M., Villoutreix,B.O., Hovnanian,A. and El Amri,C. 1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases Bioorg Med Chem Lett (2013) 23, 4547-4551. PubMed Europe PubMed DOI I

2012

Britland,S. and Hoyle,M. Transcriptional gene silencing of kallikrein 5 and kallikrein 7 using siRNA prevents epithelial cell detachment induced by alkaline shock in an in vitro model of eczema Biotechnol Prog (2012) 28, 485-489. PubMed Europe PubMed DOI
Clements,J.A., Hooper,J.D. and Dong,Y. The human tissue kallikrein and kallikrein-related peptidase family [ISSN:978-0-12-407742-3] (2012) 3, 2747-2756. DOI
Goettig,P. and Magdolen,V. Kallikrein-related peptidase 5 [ISSN:978-0-12-407742-3] (2012) 3, 2772-2778. DOI

2011

Jiang,R., Shi,Z., Johnson,J.J., Liu,Y. and Stack,M.S. Kallikrein-5 promotes cleavage of desmoglein-1 and loss of cell-cell cohesion in oral squamous cell carcinoma J Biol Chem (2011) 286, 9127-9135. PubMed Europe PubMed DOI
Teixeira,T.S., Freitas,R.F., Abrahao,O., Jr., Devienne,K.F., de Souza,L.R., Blaber,S.I., Blaber,M., Kondo,M.Y., Juliano,M.A., Juliano,L. and Puzer,L. Biological evaluation and docking studies of natural isocoumarins as inhibitors for human kallikrein 5 and 7 Bioorg Med Chem Lett (2011) 21, 6112-6115. PubMed Europe PubMed DOI I

2010

Angelopoulou,K. and Karagiannis,G.S. Structural characterization and expression of five novel canine kallikrein-related peptidases in mammary cancer Mamm Genome (2010) 21, 516-524. PubMed Europe PubMed DOI

2009

Briot,A., Deraison,C., Lacroix,M., Bonnart,C., Robin,A., Besson,C., Dubus,P. and Hovnanian,A. Kallikrein 5 induces atopic dermatitis-like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome J Exp Med (2009) 206, 1135-1147. PubMed Europe PubMed DOI PMC EPMC

2008

Clements,J.A. Reflections on the tissue kallikrein and kallikrein-related peptidase family - from mice to men - what have we learnt in the last two decades? Biol Chem (2008) 389, 1447-1454. PubMed Europe PubMed DOI V
Debela,M., Beaufort,N., Magdolen,V., Schechter,N.M., Craik,C.S., Schmitt,M., Bode,W. and Goettig,P. Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7 Biol Chem (2008) 389, 623-632. PubMed Europe PubMed DOI P S
Dong,Y., Matigian,N., Harvey,T.J., Samaratunga,H., Hooper,J.D. and Clements,J.A. Tissue-specific promoter utilisation of the kallikrein-related peptidase genes, KLK5 and KLK7, and cellular localisation of the encoded proteins suggest roles in exocrine pancreatic function Biol Chem (2008) 389, 99-109. PubMed Europe PubMed DOI
Mukai,S., Fukushima,T., Naka,D., Tanaka,H., Osada,Y. and Kataoka,H. Activation of hepatocyte growth factor activator zymogen (pro-HGFA) by human kallikrein 1-related peptidases FEBS J (2008) 275, 1003-1017. PubMed Europe PubMed DOI
Stefansson,K., Brattsand,M., Roosterman,D., Kempkes,C., Bocheva,G., Steinhoff,M. and Egelrud,T. Activation of proteinase-activated receptor-2 by human kallikrein-related peptidases J Invest Dermatol (2008) 128, 18-25. PubMed Europe PubMed DOI

2007

Borgono,C.A., Gavigan,J.A., Alves,J., Bowles,B., Harris,J.L., Sotiropoulou,G. and Diamandis,E.P. Defining the extended substrate specificity of kallikrein 1-related peptidases Biol Chem (2007) 388, 1215-1225. PubMed Europe PubMed DOI P
Debela,M., Goettig,P., Magdolen,V., Huber,R., Schechter,N.M. and Bode,W. Structural basis of the zinc inhibition of human tissue kallikrein 5 J Mol Biol (2007) 373, 1017-1031. PubMed Europe PubMed DOI S
Deraison,C., Bonnart,C., Lopez,F., Besson,C., Robinson,R., Jayakumar,A., Wagberg,F., Brattsand,M., Hachem,J.P., Leonardsson,G. and Hovnanian,A. LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction Mol Biol Cell (2007) 18, 3607-3619. PubMed Europe PubMed DOI PMC EPMC
Fernando,S.C., Najar,F.Z., Guo,X., Zhou,L., Fu,Y., Geisert,R.D., Roe,B.A. and DeSilva,U. Porcine kallikrein gene family: genomic structure, mapping, and differential expression analysis Genomics (2007) 89, 429-438. PubMed Europe PubMed DOI
Shinoda,Y., Kozaki,K., Imoto,I., Obara,W., Tsuda,H., Mizutani,Y., Shuin,T., Fujioka,T., Miki,T. and Inazawa,J. Association of KLK5 overexpression with invasiveness of urinary bladder carcinoma cells Cancer Sci (2007) 98, 1078-1086. PubMed Europe PubMed DOI
Yoon,H., Laxmikanthan,G., Lee,J., Blaber,S.I., Rodriguez,A., Kogot,J.M., Scarisbrick,I.A. and Blaber,M. Activation profiles and regulatory cascades of the human kallikrein-related peptidases J Biol Chem (2007) 282, 31852-31864. PubMed Europe PubMed DOI V

2006

[YEAR:1-6-2006]Debela,M., Magdolen,V., Schechter,N., Valachova,M., Lottspeich,F., Craik,C.S., Choe,Y., Bode,W. and Goettig,P. Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences J Biol Chem (1-6-2006) 281, 25678-25688. PubMed Europe PubMed DOI P
Luo,L.Y. and Jiang,W. Inhibition profiles of human tissue kallikreins by serine protease inhibitors Biol Chem (2006) 387, 813-816. PubMed Europe PubMed DOI
[YEAR:3-3-2006]Michael,I.P., Pampalakis,G., Mikolajczyk,S.D., Malm,J., Sotiropoulou,G. and Diamandis,E.P. Human tissue kallikrein 5 is a member of a proteolytic cascade pathway involved in seminal clot liquefaction and potentially in prostate cancer progression J Biol Chem (3-3-2006) 281, 12743-12750. PubMed Europe PubMed DOI
Prezas,P., Arlt,M.J., Viktorov,P., Soosaipillai,A., Holzscheiter,L., Schmitt,M., Talieri,M., Diamandis,E.P., Kruger,A. and Magdolen,V. Overexpression of the human tissue kallikrein genes KLK4, 5, 6, and 7 increases the malignant phenotype of ovarian cancer cells Biol Chem (2006) 387, 807-811. PubMed Europe PubMed DOI
Rajapakse,S., Ogiwara,K., Yamano,N., Kimura,A., Hirata,K., Takahashi,S. and Takahashi,T. Characterization of mouse tissue kallikrein 5 Zoolog Sci (2006) 23, 963-968. PubMed Europe PubMed DOI

2005

Brattsand,M., Stefansson,K., Lundh,C., Haasum,Y. and Egelrud,T. A proteolytic cascade of kallikreins in the stratum corneum J Invest Dermatol (2005) 124, 198-203. PubMed Europe PubMed DOI
Egelrud,T., Brattsand,M., Kreutzmann,P., Walden,M., Vitzithum,K., Marx,U.C., Forssmann,W.G. and Magert,H.J. hK5 and hK7, two serine proteinases abundant in human skin, are inhibited by LEKTI domain 6 Br J Dermatol (2005) 153, 1200-1203. PubMed Europe PubMed DOI P
[YEAR:25-5-2005]Kurlender,L., Borgono,C., Michael,I.P., Obiezu,C., Elliott,M.B., Yousef,G.M. and Diamandis,E.P. A survey of alternative transcripts of human tissue kallikrein genes Biochim Biophys Acta (25-5-2005) 1755, 1-14. PubMed Europe PubMed DOI R
[YEAR:13-1-2005]Michael,I.P., Kurlender,L., Memari,N., Yousef,G.M., Du,D., Grass,L., Stephan,C., Jung,K. and Diamandis,E.P. Intron retention: a common splicing event within the human kallikrein gene family Clin Chem (13-1-2005) 51, 506-515. PubMed Europe PubMed DOI R
[YEAR:15-2-2005]Michael,I.P., Sotiropoulou,G., Pampalakis,G., Magklara,A., Ghosh,M., Wasney,G. and Diamandis,E.P. Biochemical and enzymatic characterization of human kallikrein 5 (hK5), a novel serine protease potentially involved in cancer progression J Biol Chem (15-2-2005) 280, 14628-14635. PubMed Europe PubMed DOI
Schechter,N.M., Choi,E.J., Wang,Z.M., Hanakawa,Y., Stanley,J.R., Kang,Y., Clayman,G.L. and Jayakumar,A. Inhibition of human kallikreins 5 and 7 by the serine protease inhibitor lympho-epithelial Kazal-type inhibitor (LEKTI) Biol Chem (2005) 386, 1173-1184. PubMed Europe PubMed DOI

2004

Caubet,C., Jonca,N., Brattsand,M., Guerrin,M., Bernard,D., Schmidt,R., Egelrud,T., Simon,M. and Serre,G. Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7 J Invest Dermatol (2004) 122, 1235-1244. PubMed Europe PubMed DOI
Clements,J.A., Hooper,J.D., Odorico,D.M. and Dong,Y. The tissue kallikrein gene cluster [ISSN:0-12-079610-4] (2004) 2, 1569-1577. V
Kurlender,L., Yousef,G.M., Memari,N., Robb,J.D., Michael,I.P., Borgono,C., Katsaros,D., Stephan,C., Jung,K. and Diamandis,E.P. Differential expression of a human kallikrein 5 (KLK5) splice variant in ovarian and prostate cancer Tumour Biol (2004) 25, 149-156. PubMed Europe PubMed DOI R
Yousef,G.M., White,N.M., Kurlender,L., Michael,I., Memari,N., Robb,J.D., Katsaros,D., Stephan,C., Jung,K. and Diamandis,E.P. The kallikrein gene 5 splice variant 2 is a new biomarker for breast and ovarian cancer Tumour Biol (2004) 25, 221-227. PubMed Europe PubMed DOI

2003

[YEAR:1-5-2003]Yousef,G.M., Polymeris,M.E., Yacoub,G.M., Scorilas,A., Soosaipillai,A., Popalis,C., Fracchioli,S., Katsaros,D. and Diamandis,E.P. Parallel overexpression of seven kallikrein genes in ovarian cancer Cancer Res (1-5-2003) 63, 2223-2227. PubMed Europe PubMed
[YEAR:15-7-2003]Yousef,G.M., Polymeris,M.E., Grass,L., Soosaipillai,A., Chan,P.C., Scorilas,A., Borgono,C., Harbeck,N., Schmalfeldt,B., Dorn,J., Schmitt,M. and Diamandis,E.P. Human kallikrein 5: a potential novel serum biomarker for breast and ovarian cancer Cancer Res (15-7-2003) 63, 3958-3965. PubMed Europe PubMed
[YEAR:28-7-2003]Yousef,G.M., Kapadia,C., Polymeris,M.E., Borgono,C., Hutchinson,S., Wasney,G.A., Soosaipillai,A. and Diamandis,E.P. The human kallikrein protein 5 (hK5) is enzymatically active, glycosylated and forms complexes with two protease inhibitors in ovarian cancer fluids Biochim Biophys Acta (28-7-2003) 1628, 88-96. PubMed Europe PubMed DOI

2002

Yousef,G.M., Scorilas,A., Kyriakopoulou,L.G., Rendl,L., Diamandis,M., Ponzone,R., Biglia,N., Giai,M., Roagna,R., Sismondi,P. and Diamandis,E.P. Human kallikrein gene 5 (KLK5) expression by quantitative PCR: an independent indicator of poor prognosis in breast cancer Clin Chem (2002) 48, 1241-1250. PubMed Europe PubMed
[YEAR:1-5-2002]Yousef,G.M., Scorilas,A., Chang,A., Rendl,L., Diamandis,M., Jung,K. and Diamandis,E.P. Down-regulation of the human kallikrein gene 5 (KLK5) in prostate cancer tissues Prostate (1-5-2002) 51, 126-132. PubMed Europe PubMed DOI
Yousef,G.M., Obiezu,C.V., Jung,K., Stephan,C., Scorilas,A. and Diamandis,E.P. Differential expression of kallikrein gene 5 in cancerous and normal testicular tissues Urology (2002) 60, 714-718. PubMed Europe PubMed DOI

2001

Clements,J., Hooper,J., Dong,Y. and Harvey,T. The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions Biol Chem (2001) 382, 5-14. PubMed Europe PubMed DOI V
[YEAR:2-3-2001]Kim,H., Scorilas,A., Katsaros,D., Yousef,G.M., Massobrio,M., Fracchioli,S., Piccinno,R., Gordini,G. and Diamandis,E.P. Human kallikrein gene 5 (KLK5) expression is an indicator of poor prognosis in ovarian cancer Br J Cancer (2-3-2001) 84, 643-650. PubMed Europe PubMed DOI PMC EPMC

2000

Diamandis,E.P., Yousef,G.M., Luo,L.Y., Magklara,A. and Obiezu,C.V. The new human kallikrein gene family: implications in carcinogenesis Trends Endocrinol Metab (2000) 11, 54-60. PubMed Europe PubMed DOI
Ekholm,I.E., Brattsand,M. and Egelrud,T. Stratum corneum tryptic enzyme in normal epidermis: A missing link in the desquamation process? J Invest Dermatol (2000) 114, 56-63. PubMed Europe PubMed DOI

1999

[YEAR:15-10-1999]Brattsand,M. and Egelrud,T. Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation J Biol Chem (15-10-1999) 274, 30033-30040. PubMed Europe PubMed DOI E
[YEAR:31-12-1999]Yousef,G.M. and Diamandis,E.P. The new kallikrein-like gene, KLK-L2. Molecular characterization, mapping, tissue expression, and hormonal regulation J Biol Chem (31-12-1999) 274, 37511-37516. PubMed Europe PubMed DOI

1994

[YEAR:15-7-1994]Southard-Smith,M., Pierce,J.C. and Macdonald,R.J. Physical mapping of the rat tissue kallikrein family in two gene clusters by analysis of P1 bacteriophage clones Genomics (15-7-1994) 22, 404-417. PubMed Europe PubMed DOI

1992

Berg,T., Bradshaw,R.A., Carretero,O.A., Chao,J., Chao,L., Clements,J.A., Fahnestock,M., Fritz,H., Gauthier,F. and Macdonald,R.J. A common nomenclature for members of the tissue (glandular) kallikrein gene families Agents Actions Suppl (1992) 38, 19-25. PubMed Europe PubMed DOI