Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P00747

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
19	unknown peptidase	1-810	P	release of a signal peptide	NT	Wiman & Wallen, 1975
78	matrix metallopeptidase-3	20-810	P	conversion to two-chain form		Lijnen et al., 1998
93	cathepsin D	20-810	P	normal turnover		Morikawa et al., 2000
94	cathepsin V	20-810	P	normal turnover	NT	Puzer et al., 2008
96	aureolysin	20-810	N			Beaufort et al., 2008
96	matrix metallopeptidase-2	20-810	P		NT	Cornelius et al., 1998
96	kallikrein-related peptidase 5	20-810	P		NT	Michael et al., 2005
96	kallikrein-related peptidase 14	20-810	P			Borgoño et al., 2007
96	plasmin	20-810	P			Castellino, 2004
97	aureolysin	20-810	N			Beaufort et al., 2008
99	vibriolysin	20-810	N		NT	Chang et al., 2005
358	cathepsin V	20-810	P	normal turnover	NT	Puzer et al., 2008
372	matrix metallopeptidase-2	20-810	P		NT	Cornelius et al., 1998
443	thermolysin	20-810	N			Narasaki et al., 2005
458	kallikrein-related peptidase 3	20-810	P			Heidtmann et al., 1999
460	aureolysin	20-810	N			Beaufort et al., 2008
460	kallikrein-related peptidase 6	20-810	P		-	Bayés et al., 2004
465	matrix metallopeptidase-9	20-810	P	normal turnover		Patterson & Sang, 1997
466	matrix metallopeptidase-3	20-810	P	conversion to two-chain form		Lijnen et al., 1998
466	matrix metallopeptidase-7	20-810	P	normal turnover		Patterson & Sang, 1997
468	cathepsin V	20-810	P	normal turnover	NT	Puzer et al., 2008
469	cathepsin S	20-810	P		NT	Coppini et al., 2010
470	cathepsin D	20-810	P	normal turnover		Morikawa et al., 2000
487	plasmin	20-810	P			Kwon et al., 2005
549	kallikrein-related peptidase 5	20-810	P		NT	Michael et al., 2005
549	kallikrein-related peptidase 14	20-810	P			Borgoño et al., 2007
563	matrix metallopeptidase-3	20-810	P	normal turnover		Lijnen et al., 1998
580	omptin	20-810	N			McCarter et al., 2004
580	plasminogen activator Pla	20-810	P			Korhonen et al., 2004
580	brachyurin-T	20-810	P			You et al., 2004
580	snake venom plasminogen activator	20-810	P			Zhang et al., 1997
580	urokinase-type plasminogen activator	20-810	P			Robbins et al., 1967
580	t-plasminogen activator	20-810	P			Anglés-Cano & Rojas, 2002
580	lumbrokinase	20-810	N		NT	Zhao et al., 2007
580	snake venom coagulation factor X activator, serine-type (Bungarus fasciatus, Cerastes vipera, Ophiophagus hannah)	20-810	P			Zhang et al., 1995
718	cathepsin D	20-810	P	normal turnover		Morikawa et al., 2000