Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P02675

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
30	unknown peptidase	1-491	P	release of a signal peptide	NT
44	membrane-type matrix metallopeptidase-1	31-491	P			Bini et al., 1999
44	kallikrein-related peptidase 5	31-491	P			Michael et al., 2005
44	kallikrein-related peptidase 14	31-491	P			Borgoņo et al., 2007
44	thrombin	31-491	P			Le Bonniec, 2004
44	gabonase (Bitis gabonica)	31-491	P			Markland & Swenson, 2004
44	kangshuanmei peptidase	31-491	P		NT	Zhang et al., 2001
48	ammodytase	45-491	P		NT	Leonardi et al., 2007
51	tryptase alpha	45-491	P			Thomas et al., 1998
51	plasmin	31-491	P			Yuan et al., 2009
52	ammodytase	45-491	P		NT	Leonardi et al., 2007
72	staphopain B	45-491	N			Massimi et al., 2002
72	plasmin	31-491	P			Yuan et al., 2009
72	halystase	45-491	P			Matsui et al., 1998
77	plasmin	31-491	P			Yuan et al., 2009
80	matrix metallopeptidase-3	31-491	P			Bini et al., 1999
80	membrane-type matrix metallopeptidase-1	31-491	P			Bini et al., 1999
81	matrix metallopeptidase-3	31-491	P			Bini et al., 1999
83	kallikrein-related peptidase 5	31-491	P		NT	Michael et al., 2005
83	factor VII-activating peptidase	31-44	P			Choi-Miura et al., 2001
83	plasmin	31-491	P			Yuan et al., 2009
87	halystase	45-491	P			Matsui et al., 1998
123	matrix metallopeptidase-13	45-491	P	normal turnover		Hiller et al., 2000
150	matrix metallopeptidase-3	31-491	P			Bini et al., 1999
150	matrix metallopeptidase-7	31-491	P			Bini et al., 1999
152	unknown peptidase	1-491	P		NT	<%Agarwal et al., 2012[]%>
153	matrix metallopeptidase-7	31-491	P			Bini et al., 1999
153	membrane-type matrix metallopeptidase-1	31-491	P			Bini et al., 1999
156	matrix metallopeptidase-3	31-491	P			Bini et al., 1999
160	unknown peptidase	1-491	P		NT	<%Agarwal et al., 2012[]%>
163	plasmin	31-491	P			Bini et al., 1999
167	membrane-type matrix metallopeptidase-1	31-491	P			Bini et al., 1999
171	matrix metallopeptidase-3	31-491	P			Bini et al., 1999
171	matrix metallopeptidase-7	31-491	P			Bini et al., 1999
171	membrane-type matrix metallopeptidase-1	31-491	P			Bini et al., 1999
177	carboxypeptidase N	169-178	N		NT	Myles et al., 2003
177	carboxypeptidase B2	169-178	N		NT	Myles et al., 2003