Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P22692

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
21	kallikrein-related peptidase 5	1-258	P		NT	Michael et al., 2006
21	unknown peptidase	1-258	P	release of a signal peptide	NT	Culouscou & Shoyab, 1991
23	calpain-1	22-258	P			Ghosh et al., 2005
107	calpain-1	22-258	P			Ghosh et al., 2005
143	calpain-1	22-258	P			Ghosh et al., 2005
155	cathepsin D	22-258	P	normal turnover		Claussen et al., 1997
156	pappalysin-1	22-258	P			Qin et al., 2000
159	calpain-1	22-258	P			Ghosh et al., 2005
191	kallikrein-related peptidase 5	22-258	P		NT	Michael et al., 2006