Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P02671

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
19	matrix metallopeptidase-8	1-866	P	release of a signal peptide		Hiller et al., 2000
19	matrix metallopeptidase-12	1-866	P	release of a signal peptide		Hiller et al., 2000
19	matrix metallopeptidase-13	1-866	P	release of a signal peptide		Hiller et al., 2000
19	unknown peptidase	1-866	P	release of a signal peptide		Hiller et al., 2000
24	EcpA peptidase	20-35	N			Oleksy et al., 2004
27	matrix metallopeptidase-7	19-866	P	normal turnover		Bini et al., 1999
35	matrix metallopeptidase-3	19-866	P			Bini et al., 1999
35	matrix metallopeptidase-7	19-866	P			Bini et al., 1999
35	membrane-type matrix metallopeptidase-1	19-866	P			Bini et al., 1999
35	crotalase	19-866	N
35	bothrombin	19-866	N			Nishida et al., 1994
35	thrombin	19-866	P			Lord et al., 1990
35	plasmin	19-866	P			Yuan et al., 2009
35	rhombeobin (Lachesis muta rhombeata )	20-866	P		NT	Silveira et al., 1989
35	kangshuanmei peptidase	20-866	P		NT	Zhang et al., 2001
35	coagulant peptidase (Trimeresurus flavoviridis)	19-866	P			Shieh et al., 1985
38	matrix metallopeptidase-3	19-866	P	release of a bioactive peptide		Bini et al., 1999
38	matrix metallopeptidase-7	19-866	P			Bini et al., 1999
38	kallikrein-related peptidase 14	20-866	P			Borgoņo et al., 2007
38	plasmin	19-866	P			Yuan et al., 2009
41	ulilysin (Methanosarcina acetivorans)	36-866	N			Tallant et al., 2006
100	unknown peptidase	1-866	P		NT	<%Agarwal et al., 2012[]%>
104	membrane-type matrix metallopeptidase-1	36-866	P			Hiller et al., 2000
116	matrix metallopeptidase-7	19-866	P	normal turnover		Bini et al., 1999
116	membrane-type matrix metallopeptidase-1	36-866	P			Hiller et al., 2000
121	matrix metallopeptidase-3	19-866	P			Bini et al., 1999
121	membrane-type matrix metallopeptidase-1	19-866	P			Bini et al., 1999
123	plasmin	19-866	P			Bini et al., 1999
238	cathepsin D	36-866	P	normal turnover		Simon et al., 1994
260	matrix metallopeptidase-7	19-866	P			Bini et al., 1999
268	matrix metallopeptidase-7	19-866	P			Bini et al., 1999
367	kallikrein-related peptidase 5	20-866	P		NT	Michael et al., 2005
413	cathepsin D	36-866	P	normal turnover		Simon et al., 1994
426	kallikrein-related peptidase 5	20-866	P		NT	Michael et al., 2005
428	unknown peptidase	427-436	N		MS	Siigur et al., 2011
432	matrix metallopeptidase-3	19-866	P			Bini et al., 1999
432	matrix metallopeptidase-12	36-866	P	normal turnover		Hiller et al., 2000
432	membrane-type matrix metallopeptidase-1	36-866	P			Hiller et al., 2000
432	matrix metallopeptidase-26	36-866	P			Park et al., 2002
432	fibrolase	36-866	N			Swenson & Markland, 1998
432	basilysin	36-866	N			Markland & Swenson, 2004
432	mutalysin II	425-439	N			<%Sanchez, 2012[]%>
432	lebetase	36-866	N			Siigur & Siigur, 2004
432	mocarhagin	36-866	N			Andrews & Berndt, 2004
441	matrix metallopeptidase-8	36-866	P			Hiller et al., 2000
441	matrix metallopeptidase-7	19-866	P			Bini et al., 1999
441	matrix metallopeptidase-13	36-866	P	normal turnover		Hiller et al., 2000
441	matrix metallopeptidase-26	36-866	P			Park et al., 2002
441	ammodytase	36-866	P		NT	Leonardi et al., 2007
510	kallikrein-related peptidase 14	20-866	P			Borgoņo et al., 2007
510	halystase	36-866	P			Matsui et al., 1998
520	mocarhagin	36-866	N			Andrews & Berndt, 2004
524	basilysin	36-866	N			Markland & Swenson, 2004
535	lebetase	36-866	N			Siigur & Siigur, 2004
539	matrix metallopeptidase-7	19-866	P			Bini et al., 1999
539	matrix metallopeptidase-12	36-866	P	normal turnover		Hiller et al., 2000
539	ammodytase	36-866	P		NT	Leonardi et al., 2007
540	cathepsin D	36-866	P	normal turnover		Simon et al., 1994
579	basilysin	36-866	N			Markland & Swenson, 2004
591	tryptase beta	36-866	P			Thomas et al., 1998
591	tryptase alpha	36-866	P		NT	Thomas et al., 1998
601	carboxypeptidase B2	590-602	N		MS	Valnickova et al., 2007