Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P03973

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
25	unknown peptidase	1-132	P	release of a signal peptide		Tam et al., 2004
40	elastase-2	26-132	P		MS	Weldon et al., 2009
41	elastase-2	26-132	P		MS	Weldon et al., 2009
45	kallikrein-related peptidase 5	26-132	P		NT	Borgoņo et al., 2007
45	kallikrein-related peptidase 14	26-132	P		NT	Borgoņo et al., 2007
45	kallikrein 1	26-132	P		NT	Borgoņo et al., 2007
45	kallikrein-related peptidase 3	26-132	P			Ohlsson et al., 1995
92	cathepsin L	26-132	P	normal turnover		Taggart et al., 2001
92	cathepsin S	26-132	P	normal turnover		Taggart et al., 2001
92	cathepsin B	26-132	P	normal turnover		Taggart et al., 2001
97	kallikrein-related peptidase 14	26-132	P		NT	Borgoņo et al., 2007
97	kallikrein-related peptidase 6	26-132	P		NT	Borgoņo et al., 2007
98	kallikrein-related peptidase 3	26-132	P			Ohlsson et al., 1995