Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P04004

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
19	unknown peptidase	1-478	P	release of a signal peptide		Borgoņo et al., 2007
27	kallikrein-related peptidase 5	20-478	P		NT	Michael et al., 2005
64	kallikrein-related peptidase 14	20-478	P			Borgoņo et al., 2007
66	granzyme B (Homo sapiens-type)	20-478	P			Buzza et al., 2005
134	matrix metallopeptidase-26	20-478	P			Park et al., 2002
197	kallikrein-related peptidase 14	20-478	P			Borgoņo et al., 2007
380	plasmin	20-478	P			Chain et al., 1991
398	unknown peptidase	1-478	P		NT	<%Agarwal et al., 2012[]%>