Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P17936

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
27	kallikrein-related peptidase 5	1-291	P		NT	Michael et al., 2006
27	unknown peptidase	1-291	P	release of a signal peptide	NT	Zhang & Henzel, 2004
36	matrix metallopeptidase-3	28-291	P	normal turnover		Gibson & Cohen, 1999
122	matrix metallopeptidase-7	28-291	P	normal turnover		Miyamoto et al., 2004
122	plasmin	28-291	P			Lalou et al., 1997
123	matrix metallopeptidase-1	28-291	P	normal turnover		Fowlkes et al., 1994
123	matrix metallopeptidase-2	28-291	P	normal turnover		Fowlkes et al., 1994
124	matrix metallopeptidase-1	28-291	P	normal turnover		Gibson & Cohen, 1999
124	matrix metallopeptidase-2	28-291	P			Gibson & Cohen, 1999
124	ADAM28 peptidase (mouse-type)	28-291	P		NT	Mochizuki et al., 2004
124	ADAM28 peptidase (Homo sapiens-type)	28-291	P		NT	Mochizuki et al., 2004
124	thrombin	28-291	P			Booth et al., 1996
124	plasmin	28-291	P			Gibson & Cohen, 1999
125	cathepsin D	28-291	P	normal turnover		Claussen et al., 1997
126	matrix metallopeptidase-1	28-291	P	normal turnover		Fowlkes et al., 1994
126	matrix metallopeptidase-2	28-291	P	normal turnover		Fowlkes et al., 1994
126	matrix metallopeptidase-3	28-291	P	normal turnover		Fowlkes et al., 1994
136	matrix metallopeptidase-3	28-291	P	normal turnover		Fowlkes et al., 1994
158	kallikrein-related peptidase 3	28-291	P			Okabe et al., 1999
168	matrix metallopeptidase-1	28-291	P	normal turnover		Fowlkes et al., 1994
168	matrix metallopeptidase-2	28-291	P	normal turnover		Fowlkes et al., 1994
168	cathepsin G	28-291	P			Gibson & Cohen, 1999
169	matrix metallopeptidase-1	28-291	N			Gibson & Cohen, 1999
169	matrix metallopeptidase-2	28-291	P	normal turnover		Gibson & Cohen, 1999
169	plasmin	28-291	P			Lalou et al., 1997
171	matrix metallopeptidase-7	28-291	P	normal turnover		Miyamoto et al., 2004
172	cathepsin L	28-291	P	normal turnover		Zwad et al., 2002
175	elastase-2	28-291	P			Gibson & Cohen, 1999
185	kallikrein-related peptidase 5	28-291	P		NT	Michael et al., 2006
185	plasmin	28-291	P			Lalou et al., 1997
186	cathepsin D	28-291	P	normal turnover		Claussen et al., 1997
186	kallikrein-related peptidase 3	28-291	P			Okabe et al., 1999
187	plasmin	28-291	P			Lalou et al., 1997
190	cathepsin D	28-291	P	normal turnover		Claussen et al., 1997
190	meprin alpha subunit	28-291	N		MS	Becker-Pauly et al., 2011
190	meprin beta subunit	28-291	N		MS	Becker-Pauly et al., 2011
194	meprin alpha subunit	28-291	N		MS	Becker-Pauly et al., 2011
194	meprin beta subunit	28-291	N		MS	Becker-Pauly et al., 2011
194	procollagen C-peptidase	28-291	P		NT	Kim et al., 2011
203	matrix metallopeptidase-3	28-291	P	normal turnover		Fowlkes et al., 1994
217	meprin beta subunit	28-291	N		MS	Becker-Pauly et al., 2011
218	meprin alpha subunit	28-291	N		MS	Becker-Pauly et al., 2011
218	meprin beta subunit	28-291	N		MS	Becker-Pauly et al., 2011
225	plasmin	28-291	P			Lalou et al., 1997
226	cathepsin G	28-291	P			Gibson & Cohen, 1999
227	cathepsin D	28-291	P	normal turnover		Claussen et al., 1997
233	kallikrein-related peptidase 5	28-291	P		NT	Michael et al., 2006
233	thrombin	28-291	P			Booth et al., 1996
235	elastase-2	28-291	P	normal turnover		Gibson & Cohen, 1999
247	plasmin	28-291	P			Lalou et al., 1997