Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P25116

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
25	thrombin	1-425	P			Loew et al., 2000
25	unknown peptidase	27-425	P	release of a signal peptide		Loew et al., 2000
26	unknown peptidase	1-425	P		NT	<%Agarwal et al., 2012[]%>
32	calpain-1	27-425	N			Loew et al., 2000
32	plasmin	27-425	P			Loew et al., 2000
36	elastase-2	27-425	P			Loew et al., 2000
36	myeloblastin	27-425	P			Loew et al., 2000
41	matrix metallopeptidase-1	27-425	P	release of an activation peptide		Boire et al., 2005
41	granzyme B (Homo sapiens-type)	38-60	N		MS	Parry et al., 1996
41	kallikrein-related peptidase 5	27-425	P			Oikonomopoulou et al., 2006
41	kallikrein-related peptidase 14	27-425	P			Oikonomopoulou et al., 2006
41	elastase-2	27-425	P
41	cathepsin G	27-425	P			Loew et al., 2000
41	granzyme A	27-425	P
41	tryptase alpha	35-46	P			Molino et al., 1997
41	trypsin 1	27-425	N			Loew et al., 2000
41	kallikrein 1	38-60	N		NT	Parry et al., 1996
41	mesotrypsin	35-53	P			Knecht et al., 2007
41	platelet-aggregating venom peptidase	27-425	P			Serrano, 2004
41	coagulation factor Xa	38-60	N		NT	Parry et al., 1996
41	thrombin	27-425	P			Loew et al., 2000
41	protein C (activated)	38-60	N		NT	Parry et al., 1996
41	plasmin	27-425	P			Loew et al., 2000
41	kallikrein-related peptidase 6	27-425	P			Oikonomopoulou et al., 2006
41	unknown peptidase	27-425	P			Kida et al., 2008
42	kallikrein-related peptidase 6	27-425	P			Oikonomopoulou et al., 2006
43	chymotrypsin A (cattle-type)	38-60	N		NT	Parry et al., 1996
43	kallikrein-related peptidase 5	27-425	P			Oikonomopoulou et al., 2006
43	kallikrein-related peptidase 14	27-425	P			Oikonomopoulou et al., 2006
43	cathepsin G	27-425	P			Loew et al., 2000
43	kallikrein-related peptidase 6	27-425	P			Oikonomopoulou et al., 2006
44	cathepsin G	27-425	P			Steinberg, 2004
45	kallikrein-related peptidase 6	27-425	P			Oikonomopoulou et al., 2006
46	chymotrypsin A (cattle-type)	38-60	N		NT	Parry et al., 1996
46	kallikrein-related peptidase 14	27-425	P			Oikonomopoulou et al., 2006
46	tryptase alpha	41-55	P			Molino et al., 1997
46	platelet-aggregating venom peptidase	27-425	P			Serrano, 2004
46	kallikrein-related peptidase 6	27-425	P			Oikonomopoulou et al., 2006
48	myeloblastin	27-425	P			Loew et al., 2000
51	tryptase alpha	41-55	P			Molino et al., 1997
54	myeloblastin	27-425	P			Loew et al., 2000
55	cathepsin G	27-425	P			Loew et al., 2000
69	cathepsin G	27-425	P			Loew et al., 2000
70	trypsin 1	27-425	N			Loew et al., 2000
70	plasmin	27-425	P			Loew et al., 2000
72	elastase-2	27-425	P			Loew et al., 2000
72	myeloblastin	27-425	P			Loew et al., 2000
74	elastase-2	27-425	P			Renesto et al., 1997
76	calpain-1	27-425	N			Loew et al., 2000
76	plasmin	27-425	P			Loew et al., 2000
82	trypsin 1	27-425	N			Loew et al., 2000
82	plasmin	27-425	P			Steinberg, 2004
86	elastase-2	27-425	P			Loew et al., 2000
92	myeloblastin	27-425	P			Loew et al., 2000