Family S37

Family

Summary Holotypes Alignment Tree Genomes Literature Architecture

Summary for family S37

Family type peptidase	S37.001 - PS-10 peptidase (Streptomyces lividans), MEROPS Accession MER0001350 (peptidase unit: 27-474)
Content of family	Family S37 contains a tripeptidyl-peptidase from Streptomyces.
History	Identifier created: Proteolysis in Cell Function, pp13-21, IOS Press, Amsterdam (1997)
Catalytic type	Serine
Active site residues	S168 D368 H399
Active site	Active site residues have not been determined for any member of this family, and the active site triad is hypothetical. As can be seen from the Alignment for clan SC, the pattern of conserved glycines around the proposed active site serine and histidine residues in family S37 is consistent with that of other families in this clan.
Activities and specificities	The peptidase from Streptomyces mobaraensis has been shown to activate the transglutaminase precursor by removal of a leading tri- or tetrapeptide (Umezawa et al., 2004). Calcium ions enhance activity (Zotzel et al., 2003).
Inhibitors	PS-10 peptidase (S37.001) is inhibited by the generic serine peptidase inhibitor PMSF (Umezawa et al., 2004).
Molecular structure	No tertiary structure has been determined for any member of the family. Peptidases in family S37 are synthesized with signal peptides (Umezawa et al., 2004).
Clan	SC
Basis of clan assignment	Active site residues for members of this family and family S10 occur in the same order in the sequence: S, D, H.

Distribution of family	Bacteria	details
	Archaea	-
	Protozoa	details
	Fungi	-
	Plants	details
	Animals	-
	Viruses	-

Biological functions	PS-10 peptidase processes the transglutaminase precursor from Streptomyces mobaraensis. Processing occurs in two stages: a metallopeptidase (M04.017) or the serine peptidase SAM-P45 (S08.069) removes the bulk of the propeptide leading to an active enzyme (Zotzel et al., 2003); PS-10 peptidase then removes an N-terminal tri- or tetrapeptide (Umezawa et al., 2004).
Statistics for family S37	Sequences:	1191
	Identifiers:	1
	Identifiers with PDB entries:	0
Downloadable files	Sequence library (FastA format)
	Sequence alignment (FastA format)
	Phylogenetic tree (Newick format)

Other databases	INTERPRO	IPR008761
	PFAM	PF05576

Peptidases and Homologues	MEROPS ID	Structure
PS-10 peptidase	S37.001	-
Family S37 non-peptidase homologues	non-peptidase homologue	-
Family S37 unassigned peptidases	unassigned	-