Family S37


Summary Holotypes Alignment Tree Genomes Literature Architecture

Summary for family S37

Family type peptidaseS37.001 - PS-10 peptidase (Streptomyces lividans), MEROPS Accession MER0001350 (peptidase unit: 27-474)
Content of familyFamily S37 contains a tripeptidyl-peptidase from Streptomyces.
History Identifier created: Proteolysis in Cell Function, pp13-21, IOS Press, Amsterdam (1997)
Catalytic typeSerine
Active site residuesS168 D368 H399 
Active siteActive site residues have not been determined for any member of this family, and the active site triad is hypothetical. As can be seen from the Alignment for clan SC, the pattern of conserved glycines around the proposed active site serine and histidine residues in family S37 is consistent with that of other families in this clan.
Activities and specificitiesThe peptidase from Streptomyces mobaraensis has been shown to activate the transglutaminase precursor by removal of a leading tri- or tetrapeptide (Umezawa et al., 2004). Calcium ions enhance activity (Zotzel et al., 2003).
InhibitorsPS-10 peptidase (S37.001) is inhibited by the generic serine peptidase inhibitor PMSF (Umezawa et al., 2004).
Molecular structureNo tertiary structure has been determined for any member of the family. Peptidases in family S37 are synthesized with signal peptides (Umezawa et al., 2004).
Basis of clan assignmentActive site residues for members of this family and family S10 occur in the same order in the sequence: S, D, H.
Distribution of family Bacteria details  
Archaea -  
Protozoa details  
Fungi -  
Plants details  
Animals -  
Viruses -  
Biological functionsPS-10 peptidase processes the transglutaminase precursor from Streptomyces mobaraensis. Processing occurs in two stages: a metallopeptidase (M04.017) or the serine peptidase SAM-P45 (S08.069) removes the bulk of the propeptide leading to an active enzyme (Zotzel et al., 2003); PS-10 peptidase then removes an N-terminal tri- or tetrapeptide (Umezawa et al., 2004).
Statistics for family S37Sequences:1191
Identifiers with PDB entries:0
Downloadable files Sequence library (FastA format)
Sequence alignment (FastA format)
Phylogenetic tree (Newick format)
Other databases INTERPRO IPR008761
PFAM PF05576
Peptidases and Homologues MEROPS ID Structure
PS-10 peptidaseS37.001-
Family S37 non-peptidase homologuesnon-peptidase homologue-
Family S37 unassigned peptidasesunassigned-