Summary for clan AF
| Clan type peptidase | A26.001 - omptin (Escherichia coli), MEROPS Accession MER0000606 (peptidase unit: 21-317); PDB accession 1I78_A |
| History | MEROPS 5.7 (17 December 2001) |
| Description | Water nucleophile; water bound by Asp and His; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane. |
| Contents of clan | Clan AF contains a single family of membrane-inserted endopeptidases. |
| Evidence | The protein fold of omptin (A26.001) from Escherischia coli is unlike that of any other peptidase, and family A26 is the single family in clan AF. |
| Catalytic mechanism | (See family A26.) |
| Peptidase activity | (See family A26.) |
| Protein fold | Omptin (A26.001) is an all-beta protein with the ten strands arranged in a cylindrical barrel which is inserted into the membrane with the active site residues on the outer surface (Vandeputte-Rutten et al., 2001). |
| Homologous non-peptidase families | The outer membrane adhesin/invasin OpcA from Neisseria meningitidis has a similar fold (Prince et al., 2002). |
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Other databases
| SCOP | 69917 |
Families
| A26 |
omptin (Escherichia coli) |
Yes |
Distribution of clan AF among Kingdoms of Organisms
