Summary for clan CF
| Clan type peptidase | C15.001 - pyroglutamyl-peptidase I (prokaryote) (Thermococcus litoralis), MEROPS Accession MER0003453 (peptidase unit: 1-220); PDB accession 1A2Z_A |
| History | MEROPS 3.03 (9 September 1998) |
| Description | Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence |
| Contents of clan | The clan contains a single family, C15. |
| Evidence | The structure of pyroglutamyl-peptidase I shows a protein fold unlike that of any other cysteine peptidase, so pyroglutamyl-peptidase I provides the type structure for clan CF. There are structural similarities detectable by the Dali program (Holm & Sander, 1997) between members of clan CF and three clans of metallopeptidases, MC, MF and MH, and all four peptidase clans are included in the phosphorylase/hydrolase-like fold by the SCOP database. |
| Protein fold | The tertiary structure for pyroglutamyl-peptidase I has been determined (Odagaki et al., 1999) and shows an alpha/beta protein with an alpha/beta/alpha sandwich. The beta sheet contains five strands (in the order 21354) with strand 4 antiparallel to the others. |
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Other databases
| SCOP | 53182 |
Families
| C15 |
pyroglutamyl-peptidase I (prokaryote) (Bacillus amyloliquefaciens) |
Yes |
Distribution of clan CF among Kingdoms of Organisms
