Family M57

Family

Summary Holotypes Alignment Tree Genomes Literature Architecture

Summary for family M57

Family type peptidase	M57.001 - prtB g.p. (Myxococcus xanthus) (Myxococcus xanthus), MEROPS Accession MER0004914 (peptidase unit: 1-265)
Content of family	Peptidase family M57 contains an endopeptidase.
History	Identifier created: MEROPS 5.61 (29 October 2001)
Catalytic type	Metallo
Active site residues	H190 E191 H194 H200
Active site	The deduced amino acid sequence shows a motif HEXXHXXGXXH/ "Met-turn" characteristic of peptidases in clan MA, subclan M (the metzincins) (Quillet et al., 1997). In this, the three histidine residues would be ligands of a zinc atom, and the glutamate would have a catalytic role (see the Alignment).
Activities and specificities	The gene encoding the prtB peptidase has the prtA gene encoding a putative serine peptidase immediately adjacent. Only when both genes were expressed together in Escherichia coli was peptidase activity detectable (Quillet et al., 1997).
Molecular structure
Clan	MA
Subclan	MA(M)
Basis of clan assignment	Predicted active site residues for members of this family and thermolysin, the type example for clan MA, occur in the motif HEXXH

Distribution of family	Bacteria	details
	Archaea	-
	Protozoa	-
	Fungi	-
	Plants	-
	Animals	details
	Viruses	-

Biological functions
Statistics for family M57	Sequences:	50
	Identifiers:	1
	Identifiers with PDB entries:	0
Downloadable files	Sequence library (FastA format)
	Sequence alignment (FastA format)
	Phylogenetic tree (Newick format)

Other databases	INTERPRO	IPR024653
	PFAM	PF12388

Peptidases and Homologues	MEROPS ID	Structure
prtB g.p. (Myxococcus xanthus)	M57.001	-
Family M57 unassigned peptidases	unassigned	-