Family C110


Summary Holotypes Genomes Literature H-seq M-seq Architecture

Summary for family C110

Family type peptidaseC110.001 - kyphoscoliosis peptidase (Mus musculus), MEROPS Accession MER0472834 (peptidase unit: 169-283)
Content of familyFamily C110 contains cysteine endopeptidases.
History Identifier created: MEROPS 10.0 (14 Mar 2016)
Family C110 includes the mammalian kyphoscoliosis peptidase. Kyphoscoliosis is curvature of the spine and a mutant (in the KY gene) associated with the condition was first identified in mouse (Blanco et al., 2001). The KY protein was shown to be a peptidase that degrades filamin C (Beatham et al., 2004). Other mutations causes a truncated KY protein and affects muscle development but does not cause scoliosis (Hedberg-Oldfors et al., 2016), congenital myopathy (Straussberg et al., 2016) and progressive hereditary spastic paraplegia (Yogev et al., 2017).
Catalytic typeCysteine
Active site residuesC225 H267 D282 
Active siteA Cys, His, Asp catalytic triad has been proposed Beatham et al., 2004).
Molecular structureNo tertiary structure has been solved for any member of the family. The KY protein has a transglutaminase-like domain. On the basis of the order of the residues in the proposed catalytic triad, family C110 is included in clan CA.
Distribution of family Bacteria details  
Archaea details  
Protozoa details  
Fungi -  
Plants -  
Animals details  
Viruses -  
Biological functions
Statistics for family C110Sequences:1311
Identifiers with PDB entries:0
Downloadable files Sequence library (FastA format)
Sequence alignment (FastA format)
Phylogenetic tree (Newick format)
Peptidases and Homologues MEROPS ID Structure
kyphoscoliosis peptidaseC110.001-
Family C110 non-peptidase homologuesnon-peptidase homologue-
Family C110 unassigned peptidasesunassigned-