Family M11
Summary for family M11
| Name | Peptidase family M11 (gametolysin family) |
|---|
| Family type peptidase | M11.001 - gametolysin (Chlamydomonas reinhardtii), MEROPS Accession MER0001103 (peptidase unit: 184-638) |
| Content of family | Peptidase family M11 contains a metallo-endopeptidase, gametolysin. |
| History |
Identifier created: Biochem.J. 290:205-218 (1993)
|
| Catalytic type | Metallo |
| Active site residues | H,Q396 E397 H400 H406 |
| Active site | Gametolysin (M11.001) has a metal-binding motif HEXXHXXXXXH. In homologues from Volvox sp., the first His of the active site motif is replaced by Gln, and it has been suggested that this substitution shifts the selectivity of metal-binding from zinc to copper (Heitzer & Hallmann, 2002). |
| Activities and specificities | Gametolysin is synthesized with an N-terminal propeptide that appears to contain a "cysteine switch" analogous to those in other families in clan MA; activation is by cleavage at the Lys3 Glu4 bond (Kinoshita et al., 1992). Gametolysin degrades the proline- and hydroxyproline-rich proteins of the algal cell wall. |
| Molecular structure | |
| Clan | MA |
| Subclan | MA(M) |
| Basis of clan assignment | Predicted active site residues for members of this family and thermolysin, the type example for clan MA, occur in the motif HEXXH |
|
Distribution of family
|
Bacteria |
details |
|
|
|
Archaea |
- |
|
|
|
Protozoa |
details |
|
|
|
Fungi |
- |
|
|
|
Plants |
details |
|
|
|
Animals |
- |
|
|
|
Viruses |
- |
|
