Summary for clan ST
| Description | Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane |
| Contents of clan | Clan ST contains membrane-bound endopeptidases that cleave within transmembrane domains of substrate proteins. |
| Evidence | The tertiary structure of the GlpG protein (S54.016) from Escherichia coli has been determined (Wang et al., 2006). |
| Catalytic mechanism | (See family S54.) |
| Peptidase activity | (See family S54.) |
| Protein fold | The fold consists of a bundle of helices. |
| Homologous non-peptidase families | The fold is unique to clan ST. |
Families
| S54 |
rhomboid-1 (Diptera) (Drosophila melanogaster) |
Yes |
Distribution of clan ST among Kingdoms of Organisms
