Summary for clan ST
Description | Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane |
Contents of clan | Clan ST contains membrane-bound endopeptidases that cleave within transmembrane domains of substrate proteins. |
Evidence | The tertiary structure of the GlpG protein (S54.016) from Escherichia coli has been determined (Wang et al., 2006). |
Catalytic mechanism | (See family S54.) |
Peptidase activity | (See family S54.) |
Protein fold | The fold consists of a bundle of helices. |
Homologous non-peptidase families | The fold is unique to clan ST. |
Families
S54 |
rhomboid-1 (Diptera) (Drosophila melanogaster) |
Yes |
Distribution of clan ST among Kingdoms of Organisms