Family C36

Family

Summary Holotypes Alignment Genomes Literature Architecture

Summary for family C36

Family type peptidase	C36.001 - beet necrotic yellow vein furovirus-type papain-like peptidase (beet necrotic yellow vein virus), MEROPS Accession MER0002121 (peptidase unit: 1283-1389)
Content of family	Peptidase family C36 contains a putative papain-like peptidase.
History	Identifier created: Perspect.Drug Discov.Des. 6:1-11 (1996) Beet necrotic yellow vein virus RNA 1 contains an ORF of which the translation product contains a methyl transferase domain, an NTP-binding/helicase domain, a polymerase domain and a putative peptidase domain.
Catalytic type	Cysteine
Active site residues	C1293 H1384
Active site	The putative peptidase domain was identified on the basis of sequence similarity to papain (Koonin et al., 1992, Rozanov et al., 1995).
Activities and specificities	Hehn %et al (1997) have demonstrated autocatalytic cleavage of the Beet necrotic yellow vein virus RNA 1 translation product into 150kDa and 66kDa fragments. This cleavage is thought to occur between the helicase and polymerase domains and is predicted to be 600 amino acids from the C-terminus of the protein, based on comparison with other alphavirus papain-like peptidases.
Molecular structure
Clan	unassigned
Basis of clan assignment	Predicted active site residues for members of this family and family C1 occur in the same order in the sequence: C, H.

Distribution of family	Bacteria	-
	Archaea	-
	Protozoa	-
	Fungi	-
	Plants	-
	Animals	-
	Viruses	details

Biological functions
Statistics for family C36	Sequences:	3
	Identifiers:	1
	Identifiers with PDB entries:	0
Downloadable files	Sequence library (FastA format)
	Sequence alignment (FastA format)

Other databases	INTERPRO	IPR008746
	PFAM	PF05415

Peptidases and Homologues	MEROPS ID	Structure
beet necrotic yellow vein furovirus-type papain-like peptidase	C36.001	-
Family C36 unassigned peptidases	unassigned	-