Summary for clan CN
| History | MEROPS 7.60 (23 October 2006) |
| Description | Cysteine nucleophile: catalytic residues in the order Cys, His in sequence |
| Contents of clan | Clan CN contains viral polyprotein endopeptidases. |
| Evidence | (See Protein fold.) |
| Catalytic mechanism | (See family C9.) |
| Peptidase activity | (See family C9.) |
| Protein fold | The tertiary structure has been determined for the nsP2 peptidase from Venezuelan equine encephalitis virus (Russo et al., 2006). There are two domains, with the peptidase confined to the N-terminal domain. |
| Homologous non-peptidase families | The fold of the peptidase domain is unique for members of clan CN. The C-terminal domain has a structure similar to proteins of the S-adenosyl-L-methionine-dependent methyltransferase family. |
Families
| C9 |
sindbis virus-type nsP2 peptidase (Sindbis virus) |
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Distribution of clan CN among Kingdoms of Organisms
