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Substrates for peptidase S01.047: human airway trypsin-like peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
P78365 109-134 peptide-Ser123+Ser-peptide N MS Asn Ser Ala Ser Ser Ile Ala Gly Barré et al., 2014
Q6ZS99 285-301 AR+TLLAKNLPYKVTQDE N MS - - Ala Arg Thr Leu Leu Ala Barré et al., 2014
116 kDa U5 small nuclear ribonucleoprotein component Q15029 487-512 peptide-Arg495+Val-peptide N MS Ala Phe Gly Arg Val Leu Ser Gly Barré et al., 2014
14-3-3 protein theta P27348 138-151 R+KQTIDNSQGAYQE N MS - - - Arg Lys Gln Thr Ile Barré et al., 2014
40S ribosomal protein S12 P25398 98-117 GKPR+KVVGCSCVVVKDYGKE N MS Gly Lys Pro Arg Lys Val Val Gly Barré et al., 2014
40S ribosomal protein S21 P63220 68-83 SILR+LAKADGIVSKNF N MS Ser Ile Leu Arg Leu Ala Lys Ala Barré et al., 2014
40S ribosomal protein S24 P62847 4-39 peptide-Arg20+Lys-peptide N MS Leu Leu Gln Arg Lys Gln Met Val Barré et al., 2014
40S ribosomal protein S3a P61247 33-68 peptide-Arg51+Thr-peptide N MS Leu Val Thr Arg Thr Gln Gly Thr Barré et al., 2014
60S ribosomal protein L10a P62906 115-142 peptide-Arg122+Ile-peptide N MS Gln Ile Pro Arg Ile Leu Gly Pro Barré et al., 2014
Abz-Arg-Gln-Asp-Arg-ANB-NH2 Abz-Arg-Gln-Asp-Arg+ANB-NH2 S Arg Gln Asp Arg ANB NH2 - - Wysocka %eta, 2010
Abz-Arg-Gln-Asp-Lys-ANB-NH2 Abz-Arg-Gln-Asp-Lys+ANB-NH2 S Arg Gln Asp Lys ANB NH2 - - Wysocka %eta, 2010
Actin, aortic smooth muscle P62736 28-59 peptide-Arg41+His-peptide N MS Gly Arg Pro Arg His Gln Gly Val Barré et al., 2014
Activator of 90 kDa heat shock protein ATPase homolog 1 O95433 246-260 R+GGKFHMVDGNVSGE N MS - - - Arg Gly Gly Lys Phe Barré et al., 2014
Adenylyl cyclase-associated protein 1 Q01518 121-136 KNR+GSKLFNHLSAVSE N MS - Lys Asn Arg Gly Ser Lys Leu Barré et al., 2014
Ataxin-2-like protein Q8IU61 359-397 peptide-Arg382+Gly-peptide N MS Leu Pro Pro Arg Gly Pro His His Barré et al., 2014
ATP synthase subunit alpha, mitochondrial Q96IR6 484-508 peptide-Arg493+Gly-peptide N MS Ala Gly Val Arg Gly Tyr Leu Asp Barré et al., 2014
ATP-dependent RNA helicase DDX50 Q9BQ39 205-222 TIKKSR+SPKVLVLAPTRE N MS Lys Lys Ser Arg Ser Pro Lys Val Barré et al., 2014
Basigin P35613 166-180 VTGHR+WLKGGVVLKE N MS Thr Gly His Arg Trp Leu Lys Gly Barré et al., 2014
Bcl-2-associated transcription factor 1 Q9NYF8 271-314 peptide-Arg299+Ser-peptide N MS Pro Ser Arg Arg Ser Pro Ala Lys Barré et al., 2014
Boc-Phe-Ser-Arg-NHMec Boc-Phe-Ser-Arg+NHMec S Boc Phe Ser Arg AMC - - - Wysocka %eta, 2010
Chromodomain-helicase-DNA-binding protein 4 Q14839 387-406 TCPR+AYHMVCLDPDMEKAPE N MS Thr Cys Pro Arg Ala Tyr His Met Barré et al., 2014
Clathrin light chain A P09496 231-248 VSRMR+SVLISLKQAPLVH N MS Ser Arg Met Arg Ser Val Leu Ile Barré et al., 2014
Cytochrome c oxidase subunit 6C P09669 65-75 MR+KAGIFQSVK N MS - Glu Met Arg Lys Ala Gly Ile Barré et al., 2014
Dihydrolipoyl dehydrogenase, mitochondrial P09622 480-492 IAR+VCHAHPTLSE N MS Asp Ile Ala Arg Val Cys His Ala Barré et al., 2014
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial P10515 314-367 peptide-Arg354+Val-peptide N MS Pro Lys Gly Arg Val Phe Val Ser Barré et al., 2014
DnaJ homolog subfamily A member 1 P31689 118-138 LYNGATR+KLALQKNVICDKCE N MS Gly Ala Thr Arg Lys Leu Ala Leu Barré et al., 2014
Double-stranded RNA-binding protein Staufen homolog 1 Q9Y3Q2 439-458 FTR+AAPNPAKATVTAMIARE N MS - Phe Thr Arg Ala Ala Pro Asn Barré et al., 2014
Dual specificity mitogen-activated protein kinase kinase 2 P36507 2-27 peptide-Arg4+Arg-peptide N MS Met Leu Ala Arg Arg Lys Pro Val Barré et al., 2014
Dynein light chain 1, cytoplasmic P63167 4-16 R+KAVIKNADMSEE N MS - - - Arg Lys Ala Val Ile Barré et al., 2014
Eukaryotic translation initiation factor 3 subunit F O00303 112-130 GAAR+VIGTLLGTVDKHSVE N MS Gly Ala Ala Arg Val Ile Gly Thr Barré et al., 2014
Eukaryotic translation initiation factor 3 subunit G O75821 164-181 HWTTR+CPYKDTLGPMQKE N MS Trp Thr Thr Arg Cys Pro Tyr Lys Barré et al., 2014
F-actin-capping protein subunit alpha-1 P52907 13-31 KVR+IAAKFITHAPPGEFNE N MS - Lys Val Arg Ile Ala Ala Lys Barré et al., 2014
Far upstream element-binding protein 2 Q92945 77-102 peptide-Arg80+Ala-peptide N MS Ala Val Gln Arg Ala Arg Gln Ile Barré et al., 2014
Filamin-B Q9UEV9 979-1000 peptide-Arg986+Lys-peptide N MS Ser Pro Ser Arg Lys Val Val Pro Barré et al., 2014
Fructose-bisphosphate aldolase A P04075 280-319 peptide-Arg304+Ala-peptide N MS Ser Tyr Gly Arg Ala Leu Gln Ala Barré et al., 2014
Glutathione synthetase P48637 145-175 peptide-Arg164+His-peptide N MS Ala Val His Arg His Val Leu Ser Barré et al., 2014
Glyceraldehyde-3-phosphate dehydrogenase P04406 318-335 FGYSNR+VVDLMAHMASKE N MS Tyr Ser Asn Arg Val Val Asp Leu Barré et al., 2014
Heat shock 70 kDa protein 1A/1B P08107 49-69 R+LIGDAAKNQVALNPQNTVFD N MS - - - Arg Leu Ile Gly Asp Barré et al., 2014
Heat shock 70 kDa protein 4 P34932 371-391 AVTR+GCALQCAILSPAFKVRE N MS Ala Val Thr Arg Gly Cys Ala Leu Barré et al., 2014
hemagglutinin {ECO:0000313|EMBL:ABM46228.1} A3R530 1-518 peptide-Arg320+Gly-peptide N NT Arg Ser Ser Arg Gly Leu Phe Gly Baron et al., 2013
hemagglutinin {ECO:0000313|EMBL:ABM46232.1} A3R534 1-536 peptide-Arg338+Gly-peptide N NT Arg Ser Arg Arg Gly Leu Phe Gly Baron et al., 2013
hemagglutinin {ECO:0000313|EMBL:AEA04408.1} F2P1E0 1-560 peptide-Arg338+Gly-peptide N NT Val Ser Ser Arg Gly Leu Phe Gly Baron et al., 2013
Heterogeneous nuclear ribonucleoprotein M P52272 707-721 RACR+MMNGMKLSGRE N MS Arg Ala Cys Arg Met Met Asn Gly Barré et al., 2014
Heterogeneous nuclear ribonucleoproteins C1/C2 Q86U45 135-199 peptide-Arg180+Gly-peptide N MS Ser Gly Gln Arg Gly Ser Ser Lys Barré et al., 2014
Hexokinase-1 Q9NNZ5 328-347 LLTR+GKFNTSDVSAIEKNKE N MS Leu Leu Thr Arg Gly Lys Phe Asn Barré et al., 2014
Histone H1.4 P10412 17-42 peptide-Arg25+Lys-peptide N MS Lys Lys Ala Arg Lys Ser Ala Gly Barré et al., 2014
Histone H2A type 1-B/E P04908 74-92 NKKTRIIPR+HLQLAIRNDE N MS Ile Ile Pro Arg His Leu Gln Leu Barré et al., 2014
Histone H2A type 1-B/E P04908 74-93 NKKTRIIPR+HLQLAIRNDEE N MS Ile Ile Pro Arg His Leu Gln Leu Barré et al., 2014
Histone H2A type 1-B/E P04908 94-122 peptide-Arg100+Val-peptide N MS Leu Leu Gly Arg Val Thr Ile Ala Barré et al., 2014
Histone H2A.V Q71UI9 77-96 LKVKRITPR+HLQLAIRGDEE N MS Ile Thr Pro Arg His Leu Gln Leu Barré et al., 2014
Histone H2B type 2-E Q16778 95-114 IQTAVR+LLLPGELAKHAVSE N MS Thr Ala Val Arg Leu Leu Leu Pro Barré et al., 2014
Histone-binding protein RBBP7 Q16576 256-274 TR+SNTTSKPSHLVDAHTAE N MS - - Thr Arg Ser Asn Thr Thr Barré et al., 2014
Importin subunit beta-1 Q14974 850-868 GRR+SKTNKAKTLATWATKE N MS - Gly Arg Arg Ser Lys Thr Asn Barré et al., 2014
Kinesin light chain 4 Q9NSK0 207-228 peptide-Arg212+Thr-peptide N MS Ala Arg Leu Arg Thr Leu His Asn Barré et al., 2014
L-lactate dehydrogenase A chain Q9UDE8 314-329 AR+LKKSADTLWGIQKE N MS - - Ala Arg Leu Lys Lys Ser Barré et al., 2014
Lamin-B1 P20700 89-99 AR+RALDDTARE N MS - - Ala Arg Arg Ala Leu Asp Barré et al., 2014
Microtubule-associated protein tau Q5CZI7 666-689 peptide-Arg666+Val-peptide N MS - - - Arg Val Gln Ser Lys Barré et al., 2014
Myosin-9 P35579 1751-1769 R+LKKANLQIDQINTDLNLE N MS - - - Arg Leu Lys Lys Ala Barré et al., 2014
Neudesin Q9UMX5 96-113 STR+GVAKMSLDPADLTHD N MS - Ser Thr Arg Gly Val Ala Lys Barré et al., 2014
Nuclear migration protein nudC Q9Y266 28-48 LVNTFFSFLR+RKTDFFIGGEE N MS Ser Phe Leu Arg Arg Lys Thr Asp Barré et al., 2014
Nucleolar protein 58 Q9Y2X3 401-417 RGIR+KISGTGKALAKTE N MS Arg Gly Ile Arg Lys Ile Ser Gly Barré et al., 2014
Nucleoporin p58/p45 Q9BVL2 324-338 IALR+TQKTPPGLQHE N MS Ile Ala Leu Arg Thr Gln Lys Thr Barré et al., 2014
Nucleoprotein TPR P12270 2132-2151 R+TVPSTPTLVVPHRTDGFAE N MS - - - Arg Thr Val Pro Ser Barré et al., 2014
Peroxiredoxin-1 Q06830 156-171 TLR+LVQAFQFTDKHGE N MS - Thr Leu Arg Leu Val Gln Ala Barré et al., 2014
Phenylalanine--tRNA ligase beta subunit Q9NSD9 551-567 IFAR+GQSVGKLGVLHPD N MS Ile Phe Ala Arg Gly Gln Ser Val Barré et al., 2014
Phenylalanine--tRNA ligase beta subunit Q9NSD9 551-573 peptide-Arg554+Gly-peptide N MS Ile Phe Ala Arg Gly Gln Ser Val Barré et al., 2014
Plasminogen activator inhibitor 1 RNA-binding protein Q9Y367 78-94 R+KNPLPPSVGVVDKKEE N MS - - - Arg Lys Asn Pro Leu Barré et al., 2014
Plasminogen activator inhibitor 1 RNA-binding protein Q9Y367 215-230 KR+GGSGSHNWGTVKDE N MS - - Lys Arg Gly Gly Ser Gly Barré et al., 2014
Profilin-1 P07737 56-76 R+SSFYVNGLTLGGQKCSVIRD N MS - - - Arg Ser Ser Phe Tyr Barré et al., 2014
Protein disulfide-isomerase A3 P30101 69-84 AAATR+LKGIVPLAKVD N MS Ala Ala Thr Arg Leu Lys Gly Ile Barré et al., 2014
Protein-L-isoaspartate(D-aspartate) O-methyltransferase Q96II9 13-30 LIHNLR+KNGIIKTDKVFE N MS His Asn Leu Arg Lys Asn Gly Ile Barré et al., 2014
Putative heat shock protein HSP 90-alpha A2 Q14568 179-196 RMGR+GTKVILHLKEDQTE N MS Arg Met Gly Arg Gly Thr Lys Val Barré et al., 2014
Putative heat shock protein HSP 90-alpha A2 Q14568 179-192 RMGR+GTKVILHLKE N MS Arg Met Gly Arg Gly Thr Lys Val Barré et al., 2014
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 O43143 2-11 SKR+HRLDLGE N MS Met Ser Lys Arg His Arg Leu Asp Barré et al., 2014
Pyruvate kinase PKM Q96E76 64-82 MIKSGMNVAR+LNFSHGTHE N MS Asn Val Ala Arg Leu Asn Phe Ser Barré et al., 2014
Pyruvate kinase PKM Q96E76 305-332 peptide-Arg319+Ala-peptide N MS Arg Cys Asn Arg Ala Gly Lys Pro Barré et al., 2014
Ribonuclease UK114 P52758 95-122 peptide-Arg107+Ala-peptide N MS Phe Pro Ala Arg Ala Ala Tyr Gln Barré et al., 2014
Ribonucleoprotein PTB-binding 1 Q8IY67 428-451 peptide-Arg431+Arg-peptide N MS Leu Pro Pro Arg Arg Gly Lys Pro Barré et al., 2014
Ribosomal L1 domain-containing protein 1 O76021 383-420 peptide-Arg407+Lys-peptide N MS Gly Lys Lys Arg Lys Ala Leu Pro Barré et al., 2014
Ribosomal L1 domain-containing protein 1 O76021 302-324 peptide-Arg310+Lys-peptide N MS Gln Gln Ala Arg Lys Thr Ala Ser Barré et al., 2014
Ribosome biogenesis regulatory protein homolog Q15050 218-237 LGR+AMQVAKVSTASVGRFQE N MS - Leu Gly Arg Ala Met Gln Val Barré et al., 2014
RNA-binding protein 10 P98175 145-158 IR+GQLQSHGVQARE N MS - - Ile Arg Gly Gln Leu Gln Barré et al., 2014
Septin-12 Q8IYM1 256-276 HLVNGRCVL+GRKTKWGIIEVE N MS Arg Cys Val Leu Gly Arg Lys Thr Barré et al., 2014
Small acidic protein O00193 90-106 SKLSGRYR+RHCGLGFSE N MS Gly Arg Tyr Arg Arg His Cys Gly Barré et al., 2014
Spermidine synthase P19623 82-110 peptide-Arg95+Lys-peptide N MS Pro Asn Pro Arg Lys Val Leu Ile Barré et al., 2014
Structural maintenance of chromosomes protein 4 Q9NTJ3 508-525 IYLSR+HNTAVSQLTKAKE N MS Tyr Leu Ser Arg His Asn Thr Ala Barré et al., 2014
Superkiller viralicidic activity 2-like 2 P42285 122-141 YLPLKPR+VGKAAKEYPFILD N MS Leu Lys Pro Arg Val Gly Lys Ala Barré et al., 2014
Syntaxin-8 Q9UNK0 78-90 R+RQNLLDDLVTRE N MS - - - Arg Arg Gln Asn Leu Barré et al., 2014
T-complex protein 1 subunit delta P50991 525-539 TVR+SILKIDDVVNTR N MS - Thr Val Arg Ser Ile Leu Lys Barré et al., 2014
Targeting protein for Xklp2 Q9ULW0 43-84 peptide-Arg62+Lys-peptide N MS Thr Pro Leu Arg Lys Ala Asn Leu Barré et al., 2014
THO complex subunit 4 Q86V81 141-154 RSGR+SLGTADVHFE N MS Arg Ser Gly Arg Ser Leu Gly Thr Barré et al., 2014
THUMP domain-containing protein 3 Q9BV44 351-374 peptide-Arg358+Ala-peptide N MS Ala Val Asn Arg Ala Ala Asn Asn Barré et al., 2014
Transmembrane protein 158 Q8WZ71 258-300 peptide-Ala285+Ala-peptide N MS Ala Ala Ala Ala Ala Ala Ala Ala Barré et al., 2014
Tubulin-specific chaperone A O75347 4-22 PRVR+QIKIKTGVVKRLVKE N MS Pro Arg Val Arg Gln Ile Lys Ile Barré et al., 2014
Urokinase plasminogen activator surface receptor Q03405 23-305 peptide-Arg105+Ala-peptide P NT Asn Ser Gly Arg Ala Val Thr Tyr Beaufort et al., 2007
Urokinase plasminogen activator surface receptor Q03405 23-305 peptide-Arg111+Ser-peptide P NT Thr Tyr Ser Arg Ser Arg Tyr Leu Beaufort et al., 2007
Vimentin Q8N850 157-172 LR+RQVDQLTNDKARVE N MS - - Leu Arg Arg Gln Val Asp Barré et al., 2014
Vinculin P18206 820-833 SGYR+ILGAVAKVRE N MS Ser Gly Tyr Arg Ile Leu Gly Ala Barré et al., 2014
von Willebrand factor A domain-containing protein 5B1 Q5TIE3 990-1007 GPQRSLATNT+LSSMKASE N MS Ala Thr Asn Thr Leu Ser Ser Met Barré et al., 2014
Zinc finger Ran-binding domain-containing protein 2 O95218 127-147 FGRKKKKYR+GKAVGPASILKE N MS Lys Lys Tyr Arg Gly Lys Ala Val Barré et al., 2014

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