Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence Q03405

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
22	unknown peptidase	1-290	P	release of a signal peptide	NT	Roldan et al., 1990
105	human airway trypsin-like peptidase	23-305	P		NT	Beaufort et al., 2007
105	trypsin 1	23-305	N			Andolfo et al., 2002
105	urokinase-type plasminogen activator	23-305	P			Andolfo et al., 2002
105	plasmin	23-305	P			Andolfo et al., 2002
106	pseudolysin	23-305	N			Leduc et al., 2007
107	elastase-2	23-305	P			Andolfo et al., 2002
108	pseudolysin	23-305	N			Leduc et al., 2007
108	matrix metallopeptidase-3	23-305	P			Andolfo et al., 2002
108	matrix metallopeptidase-12	23-305	P	normal turnover		Andolfo et al., 2002
108	matrix metallopeptidase-19	23-305	P			Andolfo et al., 2002
108	membrane-type matrix metallopeptidase-6	23-305	P			Andolfo et al., 2002
109	matrix metallopeptidase-19	23-305	P			Andolfo et al., 2002
109	membrane-type matrix metallopeptidase-6	23-305	P			Andolfo et al., 2002
109	chymotrypsin A (cattle-type)	23-305	N			Andolfo et al., 2002
109	cathepsin G	23-305	P			Beaufort et al., 2004
109	kallikrein-related peptidase 4	102-117	P			Beaufort et al., 2006
110	matrix metallopeptidase-19	23-305	P			Andolfo et al., 2002
111	matrix metallopeptidase-19	23-305	P			Andolfo et al., 2002
111	membrane-type matrix metallopeptidase-6	23-305	P			Andolfo et al., 2002
111	human airway trypsin-like peptidase	23-305	P		NT	Beaufort et al., 2007
111	trypsin 1	23-305	N			Andolfo et al., 2002
111	urokinase-type plasminogen activator	23-305	P			Andolfo et al., 2002
111	plasmin	23-305	P			Andolfo et al., 2002
111	kallikrein-related peptidase 4	102-117	P			Beaufort et al., 2006
114	cathepsin G	23-305	P			Beaufort et al., 2004
301	pseudolysin	23-305	N			Leduc et al., 2007
303	kallikrein-related peptidase 4	294-305	P			Beaufort et al., 2006
305	unknown peptidase	1-335	P		NT	<%Agarwal et al., 2012[]%>