$VAR1 = undef;

Summary for peptidase S01.047: human airway trypsin-like peptidase

Names
MEROPS Name	human airway trypsin-like peptidase
Other names	adrenal secretory serine protease, airway trypsin-like protease, HAT peptidase, TMPRSS11D g.p. (Homo sapiens)

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.047
Holotype	human airway trypsin-like peptidase (Rattus norvegicus), Uniprot accession Q8VHJ4 (peptidase unit: 186-417), MERNUM MER0011864
History	Identifier created: MEROPS 5.2 (31 August 2000)

Activity
Catalytic type	Serine
NC-IUBMB	Not yet included in IUBMB recommendations.
Activity status	human: active (Yasuoka et al., 1997) mouse: putative
Physiology	An endopeptidase with restricted specificity known from both rat adrenal gland and human airways.
Pathways	KEGG	Influenza A
Other databases	TREEFAM	http://www.treefam.org/family/TF351684
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/Rg/-/-/- (based on 100 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	6	6	9	0	19	5	10	12
Pro	4	5	11	0	0	4	4	6
Ala	10	7	14	1	10	11	10	11
Val	1	6	6	0	8	10	5	10
Leu	7	6	8	1	9	16	11	11
Ile	6	5	2	0	3	6	1	9
Met	2	2	2	0	1	2	1	2
Phe	1	6	0	0	0	1	6	1
Tyr	2	2	3	0	0	2	3	2
Trp	1	0	0	0	1	0	0	0
Ser	7	10	7	1	10	5	8	6
Thr	5	5	9	1	5	4	6	6
Cys	0	3	1	0	1	2	1	0
Asn	3	2	5	0	0	5	4	5
Gln	2	3	3	0	1	11	7	2
Asp	1	0	2	0	0	0	1	6
Glu	0	1	0	0	0	0	0	0
Lys	3	9	3	1	15	8	15	7
Arg	11	5	3	95	7	4	0	0
His	1	0	2	0	7	1	4	1

Human genetics
Gene symbol	Locus	Megabases	Ensembl	Entrez gene	Gene Cards	OMIM
TMPRSS11D	4q13.2		ENSG00000153802	9407		605369