Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence O75347

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-108	P		NT	<%Agarwal et al., 2012[]%>
38	peptidyl-Lys metallopeptidase	1-108	N		MS
41	trypsin 1	2-108	N		MS	Schilling & Overall, 2008
51	trypsin 1	2-108	N		MS	Schilling & Overall, 2008
52	trypsin 1	2-108	N		MS	Schilling & Overall, 2008
61	trypsin 1	2-108	N		MS	Schilling & Overall, 2008
69	trypsin 1	2-108	N		MS	Schilling & Overall, 2008
70	trypsin 1	2-108	N		MS	Schilling & Overall, 2008
80	trypsin 1	2-108	N		MS	Schilling & Overall, 2008
83	cathepsin K	80-98	N		MS	Schilling & Overall, 2008
83	meprin alpha subunit	2-108	N		MS	Becker-Pauly et al., 2011
86	trypsin 1	2-108	N		MS	Schilling & Overall, 2008
90	HIV-1 retropepsin	86-98	N		MS	Schilling & Overall, 2008
94	peptidyl-Lys metallopeptidase	1-108	N		MS
95	trypsin 1	2-108	N		MS	Schilling & Overall, 2008
98	trypsin 1	2-108	N		MS	Schilling & Overall, 2008
104	peptidyl-Lys metallopeptidase	1-108	N		MS
105	trypsin 1	2-108	N		MS	Schilling & Overall, 2008