Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P63220

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
7	matrix metallopeptidase-11	1-83	N			Kleifeld et al., 2010
31	matrix metallopeptidase-2	27-45	N		MS	Schilling & Overall, 2008
34	cathepsin S	28-45	N		MS	Biniossek et al., 2011
34	meprin alpha subunit	31-45	N		MS	Becker-Pauly et al., 2011
34	meprin beta subunit	31-45	N		MS	Becker-Pauly et al., 2011
34	LAST_MAM peptidase (Limulus-type)	31-45	N		MS	Becker-Pauly et al., 2011
34	cathepsin G	27-45	N		MS	Schilling & Overall, 2008
35	astacin	32-45	N		MS	Becker-Pauly et al., 2011
35	meprin alpha subunit	32-45	N		MS	Becker-Pauly et al., 2011
35	meprin beta subunit	32-45	N		MS	Becker-Pauly et al., 2011
35	cathepsin G	27-45	N		MS	Schilling & Overall, 2008
45	trypsin 1	1-83	N		MS	Schilling & Overall, 2008
71	thrombin	67-83	N		MS	Schilling & Overall, 2008