Peptide and protein substrates that are thought to be physiologically relevant are indicated by P.
Peptide and protein substrates that are not physiologically relevant are indicated by N.
How cleavage sites have been identified are indicated by the following evidence codes:
NT = N-terminal sequencing,
MS = mass spectroscopy,
MU = mutation,
CS = consensus sequence,
LC = liquid chromatography.
To see all annotated cleavages for a peptidase, click on the peptidase name.
| Cleavage Site |
Peptidase |
Residue range |
Cleavage type |
Description |
Evidence |
Reference |
|---|
| 1 |
unknown peptidase |
1-1960 |
P |
|
NT |
<%Agarwal et al., 2012[]%> |
| 14 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 29 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 45 |
matrix metallopeptidase-2 |
38-63 |
N |
|
MS |
Schilling & Overall, 2008 |
| 63 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 64 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 88 |
matrix metallopeptidase-2 |
82-102 |
N |
|
MS |
Schilling & Overall, 2008 |
| 102 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 149 |
matrix metallopeptidase-2 |
143-159 |
N |
|
MS |
Schilling & Overall, 2008 |
| 159 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 172 |
meprin alpha subunit |
169-185 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 341 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 355 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 358 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 373 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 376 |
matrix metallopeptidase-2 |
373-387 |
N |
|
MS |
Schilling & Overall, 2008 |
| 387 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 407 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 419 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 523 |
matrix metallopeptidase-2 |
494-536 |
N |
|
MS |
Schilling & Overall, 2008 |
| 536 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 567 |
matrix metallopeptidase-2 |
565-576 |
N |
|
MS |
Schilling & Overall, 2008 |
| 576 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 587 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 606 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 617 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 626 |
matrix metallopeptidase-2 |
617-637 |
N |
|
MS |
Schilling & Overall, 2008 |
| 637 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 682 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 693 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 743 |
matrix metallopeptidase-2 |
737-755 |
N |
|
MS |
Schilling & Overall, 2008 |
| 755 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 844 |
meprin beta subunit |
2-1960 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 867 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 882 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 974 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 975 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 989 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1026 |
meprin alpha subunit |
1023-1035 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 1080 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1091 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1107 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1124 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1143 |
matrix metallopeptidase-2 |
1135-1162 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1153 |
caspase-3 |
2-1960 |
P |
|
MS |
Impens et al., 2010 |
| 1162 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1165 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1173 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1195 |
meprin alpha subunit |
2-1960 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 1195 |
meprin beta subunit |
2-1960 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 1196 |
meprin alpha subunit |
2-1960 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 1196 |
meprin beta subunit |
2-1960 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 1199 |
LAST_MAM peptidase (Limulus-type) |
1196-1210 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 1201 |
HIV-1 retropepsin |
1193-1210 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1210 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1226 |
meprin beta subunit |
2-1960 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 1274 |
lysyl endopeptidase (bacteria) |
1-1960 |
N |
|
MS |
|
| 1277 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1287 |
matrix metallopeptidase-2 |
1283-1302 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1295 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1302 |
glutamyl endopeptidase I |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1342 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1352 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1357 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1361 |
matrix metallopeptidase-2 |
1357-1370 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1370 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1371 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1374 |
meprin alpha subunit |
2-1960 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 1374 |
meprin beta subunit |
2-1960 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 1388 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1423 |
meprin alpha subunit |
1420-1433 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 1423 |
LAST_MAM peptidase (Limulus-type) |
1420-1433 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 1444 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1454 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1507 |
LAST_MAM peptidase (Limulus-type) |
1504-1518 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 1508 |
matrix metallopeptidase-2 |
1505-1518 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1518 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1538 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1555 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1676 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1681 |
matrix metallopeptidase-2 |
1676-1694 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1682 |
HIV-1 retropepsin |
1676-1694 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1694 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1697 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1703 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1716 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1756 |
matrix metallopeptidase-2 |
1754-1770 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1770 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1815 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1828 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1862 |
lysyl endopeptidase (bacteria) |
1-1960 |
N |
|
MS |
|
| 1898 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1912 |
trypsin 1 |
2-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1948 |
caspase-3 |
1937-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1948 |
caspase-7 |
1937-1960 |
N |
|
MS |
Schilling & Overall, 2008 |
