Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P07737

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-140	P		NT	<%Agarwal et al., 2012[]%>
12	cathepsin S	2-26	N		MS	Biniossek et al., 2011
25	peptidyl-Lys metallopeptidase	1-140	N		MS
26	trypsin 1	2-140	N		MS	Schilling & Overall, 2008
31	matrix metallopeptidase-2	27-47	N		MS	Schilling & Overall, 2008
32	chymase (Homo sapiens-type)	2-140	P			Raymond et al., 2003
33	meprin beta subunit	2-140	N		MS	Becker-Pauly et al., 2011
37	peptidyl-Lys metallopeptidase	1-140	N		MS
38	trypsin 1	2-140	N		MS	Schilling & Overall, 2008
40	meprin alpha subunit	2-140	N		MS	Becker-Pauly et al., 2011
40	meprin beta subunit	2-140	N		MS	Becker-Pauly et al., 2011
42	cathepsin L	39-54	N		MS	Biniossek et al., 2011
42	cathepsin B	39-54	N		MS	Biniossek et al., 2011
42	meprin alpha subunit	2-140	N		MS	Becker-Pauly et al., 2011
42	meprin beta subunit	39-54	N		MS	Becker-Pauly et al., 2011
46	meprin alpha subunit	43-56	N		MS	Becker-Pauly et al., 2011
47	matrix metallopeptidase-2	38-56	N		MS	Schilling & Overall, 2008
47	glutamyl endopeptidase I	2-140	N		MS	Schilling & Overall, 2008
54	trypsin 1	2-140	N		MS	Schilling & Overall, 2008
56	trypsin 1	2-140	N		MS	Schilling & Overall, 2008
59	HIV-1 retropepsin	56-70	N		MS	Schilling & Overall, 2008
68	matrix metallopeptidase-2	66-84	N		MS	Schilling & Overall, 2008
70	trypsin 1	2-140	N		MS	Schilling & Overall, 2008
79	cathepsin S	76-89	N		MS	Biniossek et al., 2011
84	chymotrypsin A (cattle-type)	2-140	N		MS	Schilling & Overall, 2008
91	trypsin 1	2-140	N		MS	Schilling & Overall, 2008
94	cathepsin S	92-105	N		MS	Biniossek et al., 2011
98	cathepsin B	92-105	N		MS	Biniossek et al., 2011
105	trypsin 1	2-140	N		MS	Schilling & Overall, 2008
108	trypsin 1	2-140	N		MS	Schilling & Overall, 2008
116	trypsin 1	2-140	N		MS	Schilling & Overall, 2008