$VAR1 = undef;

Summary for peptidase M14.017: carboxypeptidase A4

Names
MEROPS Name	carboxypeptidase A4
Other names	carboxypeptidase A3 [obs.], carboxypeptidase A3-2 [obs.], CPA4 g.p. (Homo sapiens)

Domain architecture

MEROPS Classification
Classification	Clan MC >> Subclan (none) >> Family M14 >> Subfamily A >> M14.017
Holotype	carboxypeptidase A4 (Homo sapiens), Uniprot accession Q9UI42 (peptidase unit: 112-421), MERNUM MER0013421
History	Identifier created: MEROPS 5.3 (4 December 2000)

Activity
Catalytic type	Metallo
NC-IUBMB	Not yet included in IUBMB recommendations.
Activity status	human: putative mouse: putative
Physiology	Potentially implicated in intrauterine growth restriction associated with Silver-Russell syndrome (Bentley et al., 2003).
Other databases	TREEFAM	http://www.treefam.org/family/TF317197
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/-lf/-/-/- (based on 68 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'
Gly	5	6	6	0	0
Pro	3	12	2	1	0
Ala	6	4	5	5	4
Val	3	2	3	7	5
Leu	3	9	14	4	27
Ile	2	8	0	5	6
Met	3	0	2	1	4
Phe	8	4	3	10	14
Tyr	2	0	4	3	3
Trp	0	0	0	0	1
Ser	4	2	1	2	0
Thr	3	0	2	2	0
Cys	0	0	0	0	0
Asn	2	2	0	2	1
Gln	2	4	2	3	1
Asp	1	0	3	0	0
Glu	2	2	3	0	0
Lys	5	3	4	8	0
Arg	4	1	5	10	0
His	2	1	1	4	2