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Substrates for peptidase S01.021: DESC1 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Q9BQ02 366-377 GSVR+ARIVTDRE N MS Gly Ser Val Arg Ala Arg Ile Val Barré et al., 2014
Q9BQ02 329-357 peptide-Arg339+Ser-peptide N MS Pro Asn Ala Arg Ser Gln Pro Ser Barré et al., 2014
Q6ZS99 285-301 AR+TLLAKNLPYKVTQDE N MS - - Ala Arg Thr Leu Leu Ala Barré et al., 2014
14-3-3 protein epsilon Q7M4R4 190-205 RACR+LAKAAFDDAIAE N MS Arg Ala Cys Arg Leu Ala Lys Ala Barré et al., 2014
28 kDa heat- and acid-stable phosphoprotein Q13442 85-100 NPNR+VAQTTKKVTQLD N MS Asn Pro Asn Arg Val Ala Gln Thr Barré et al., 2014
40S ribosomal protein S10 P46783 126-141 TYRR+SAVPPGADKKAE N MS Thr Tyr Arg Arg Ser Ala Val Pro Barré et al., 2014
40S ribosomal protein S21 P63220 68-83 SILR+LAKADGIVSKNF N MS Ser Ile Leu Arg Leu Ala Lys Ala Barré et al., 2014
60 kDa heat shock protein, mitochondrial P10809 467-486 IIKR+TLKIPAMTIAKNAGVE N MS Ile Ile Lys Arg Thr Leu Lys Ile Barré et al., 2014
78 kDa glucose-regulated protein P11021 334-347 LFR+STMKPVQKVLE N MS - Leu Phe Arg Ser Thr Met Lys Barré et al., 2014
78 kDa glucose-regulated protein P11021 74-89 R+LIGDAAKNQLTSNPE N MS - - - Arg Leu Ile Gly Asp Barré et al., 2014
78 kDa glucose-regulated protein P11021 428-467 peptide-Arg439+Asn-peptide N MS Leu Ile Pro Arg Asn Thr Val Val Barré et al., 2014
Abz-Arg-Ala-Ala-Arg-Val-Val-Gly-Gly-Tyr(NO2) Abz-Arg-Ala-Ala-Arg+Val-Val-Gly-Gly-Tyr(NO2) S Arg Ala Ala Arg Val Val Gly Gly Beliveau et al., 2009
Abz-Arg-Arg-Ala-Arg-Val-Val-Gly-Gly-Tyr(NO2) Abz-Arg-Arg-Ala-Arg+Val-Val-Gly-Gly-Tyr(NO2) S Arg Arg Ala Arg Val Val Gly Gly Beliveau et al., 2009
Abz-Arg-Gln-Ala-Arg-Ala-Val-Gly-Gly-Tyr(NO2) Abz-Arg-Gln-Ala-Arg+Ala-Val-Gly-Gly-Tyr(NO2) S Arg Gln Ala Arg Ala Val Gly Gly Beliveau et al., 2009
Abz-Arg-Gln-Ala-Arg-Gln-Val-Gly-Gly-Tyr(NO2) Abz-Arg-Gln-Ala-Arg+Gln-Val-Gly-Gly-Tyr(NO2) S Arg Gln Ala Arg Gln Val Gly Gly Beliveau et al., 2009
Abz-Arg-Gln-Ala-Arg-Tyr-Val-Gly-Gly-Tyr(NO2) Abz-Arg-Gln-Ala-Arg+Tyr-Val-Gly-Gly-Tyr(NO2) S Arg Gln Ala Arg Tyr Val Gly Gly Beliveau et al., 2009
Abz-Arg-Gln-Ala-Arg-Val-Val-Gly-Gly-Tyr(NO2) Abz-Arg-Gln-Ala-Arg-Val-Val-Gly-Gly-Tyr(NO2) S Arg Gln Ala Arg Val Val Gly Gly Beliveau et al., 2009
Abz-Arg-Gln-Arg-Arg-Val-Val-Gly-Gly-Tyr(NO2) Abz-Arg-Gln-Arg-Arg+Val-Val-Gly-Gly-Tyr(NO2) S Arg Gln Arg Arg Val Val Gly Gly Beliveau et al., 2009
Abz-Arg-Gln-Leu-Arg-Val-Val-Gly-Gly-Tyr(NO2) Abz-Arg-Gln-Leu-Arg+Val-Val-Gly-Gly-Tyr(NO2) S Arg Gln Leu Arg Val Val Gly Gly Beliveau et al., 2009
Abz-Arg-Gln-Tyr-Arg-Val-Val-Gly-Gly-Tyr(NO2) Abz-Arg-Gln-Tyr-Arg+Val-Val-Gly-Gly-Tyr(NO2) S Arg Gln Tyr Arg Val Val Gly Gly Beliveau et al., 2009
Abz-Arg-Leu-Ala-Arg-Val-Val-Gly-Gly-Tyr(NO2) Abz-Arg-Leu-Ala-Arg+Val-Val-Gly-Gly-Tyr(NO2) S Arg Leu Ala Arg Val Val Gly Gly Beliveau et al., 2009
Abz-Arg-Tyr-Ala-Arg-Val-Val-Gly-Gly-Tyr(NO2) Abz-Arg-Tyr-Ala-Arg+Val-Val-Gly-Gly-Tyr(NO2) S Arg Tyr Ala Arg Val Val Gly Gly Beliveau et al., 2009
Actin, aortic smooth muscle P62736 60-74 AQSKR+GILTLKYPIE N MS Gln Ser Lys Arg Gly Ile Leu Thr Barré et al., 2014
Acyl carrier protein, mitochondrial O14561 82-96 R+VLYVLKLYDKIDPE N MS - - - Arg Val Leu Tyr Val Barré et al., 2014
Alpha-enolase Q6GMP2 417-434 LGSKAKFAGR+NFRNPLAK N MS Phe Ala Gly Arg Asn Phe Arg Asn Barré et al., 2014
Alpha-enolase Q6GMP2 54-67 KTR+YMGKGVSKAVE N MS - Lys Thr Arg Tyr Met Gly Lys Barré et al., 2014
Annexin A5 P08758 23-36 TLR+KAMKGLGTDEE N MS - Thr Leu Arg Lys Ala Met Lys Barré et al., 2014
Calmodulin Q96HK3 89-105 AFR+VFDKDGNGYISAAE N MS - Ala Phe Arg Val Phe Asp Lys Barré et al., 2014
Capping protein (Actin filament) muscle Z-line, beta, isoform CRA_d B1AK88 268-285 IVNGLR+SVQTFADKSKQE N MS Asn Gly Leu Arg Ser Val Gln Thr Barré et al., 2014
Clathrin light chain A P09496 231-248 VSRMR+SVLISLKQAPLVH N MS Ser Arg Met Arg Ser Val Leu Ile Barré et al., 2014
Clathrin light chain B P09497 212-229 VSRLR+SVLMSLKQTPLSR N MS Ser Arg Leu Arg Ser Val Leu Met Barré et al., 2014
Coiled-coil domain-containing protein 86 Q9H6F5 181-203 peptide-Arg190+Gly-peptide N MS Gly Ser Pro Arg Gly Gln His Glu Barré et al., 2014
Cytochrome c oxidase subunit 6B1 P14854 37-55 FHR+CQKAMTAKGGDISVCE N MS - Phe His Arg Cys Gln Lys Ala Barré et al., 2014
Double-stranded RNA-binding protein Staufen homolog 1 Q9Y3Q2 281-300 YGQGINPISR+LAQIQQAKKE N MS Pro Ile Ser Arg Leu Ala Gln Ile Barré et al., 2014
Dynein light chain 1, cytoplasmic P63167 4-16 R+KAVIKNADMSEE N MS - - - Arg Lys Ala Val Ile Barré et al., 2014
Dynein light chain 1, cytoplasmic P63167 4-15 R+KAVIKNADMSE N MS - - - Arg Lys Ala Val Ile Barré et al., 2014
Elongation factor 2 P13639 587-615 peptide-Arg601+Leu-peptide N MS Lys His Asn Arg Leu Tyr Met Lys Barré et al., 2014
Eukaryotic translation initiation factor 3 subunit F O00303 112-130 GAAR+VIGTLLGTVDKHSVE N MS Gly Ala Ala Arg Val Ile Gly Thr Barré et al., 2014
Eukaryotic translation initiation factor 3 subunit G O75821 164-181 HWTTR+CPYKDTLGPMQKE N MS Trp Thr Thr Arg Cys Pro Tyr Lys Barré et al., 2014
Eukaryotic translation initiation factor 4 gamma 2 Q58EZ2 8-37 peptide-Arg23+Gly-peptide N MS Gly Gly Ser Arg Gly Ala Pro Gln Barré et al., 2014
Filamin-B Q9UEV9 979-1000 peptide-Arg986+Lys-peptide N MS Ser Pro Ser Arg Lys Val Val Pro Barré et al., 2014
Flap endonuclease 1 P39748 259-272 IVR+RLDPNKYPVPE N MS - Ile Val Arg Arg Leu Asp Pro Barré et al., 2014
Fructose-bisphosphate aldolase C P09972 19-35 IALR+IVAPGKGILAADE N MS Ile Ala Leu Arg Ile Val Ala Pro Barré et al., 2014
Glu-Gly-Arg-NHPhNO2 Glu-Gly-Arg+NHPhNO2 S - Glu Gly Arg NAN - - - Hobson et al., 2004
Heat shock 70 kDa protein 4 P34932 371-391 AVTR+GCALQCAILSPAFKVRE N MS Ala Val Thr Arg Gly Cys Ala Leu Barré et al., 2014
Heterogeneous nuclear ribonucleoprotein A/B Q99729 104-124 PNTGRSR+GFGFILFKDAASVE N MS Gly Arg Ser Arg Gly Phe Gly Phe Barré et al., 2014
Heterogeneous nuclear ribonucleoprotein A/B Q99729 189-213 peptide-Arg195+Gly-peptide N MS Asn Lys Arg Arg Gly Phe Val Phe Barré et al., 2014
Heterogeneous nuclear ribonucleoprotein D-like O14979 183-207 peptide-Arg189+Gly-peptide N MS Gly Arg Ser Arg Gly Phe Gly Phe Barré et al., 2014
Heterogeneous nuclear ribonucleoprotein F P52597 212-229 RPGTAR+RYIGIVKQAGLE N MS Gly Thr Ala Arg Arg Tyr Ile Gly Barré et al., 2014
Histone H1.2 P16403 17-42 peptide-Arg33+Lys-peptide N MS Gly Thr Pro Arg Lys Ala Ser Gly Barré et al., 2014
Histone H2A type 1-B/E P04908 74-93 NKKTRIIPR+HLQLAIRNDEE N MS Ile Ile Pro Arg His Leu Gln Leu Barré et al., 2014
Histone H2B type 2-E Q16778 95-114 IQTAVR+LLLPGELAKHAVSE N MS Thr Ala Val Arg Leu Leu Leu Pro Barré et al., 2014
Histone-binding protein RBBP7 Q16576 256-274 TR+SNTTSKPSHLVDAHTAE N MS - - Thr Arg Ser Asn Thr Thr Barré et al., 2014
Importin subunit alpha-5 P52294 98-120 peptide-Arg107+Lys-peptide N MS Gln Lys Phe Arg Lys Leu Leu Ser Barré et al., 2014
Insulin-like growth factor 2 mRNA-binding protein 1 Q9NZI8 490-512 peptide-Arg501+Val-peptide N MS Ala Ala Gly Arg Val Ile Gly Lys Barré et al., 2014
Insulin-like growth factor 2 mRNA-binding protein 1 Q9NZI8 215-230 GATIR+NITKQTQSKID N MS Ala Thr Ile Arg Asn Ile Thr Lys Barré et al., 2014
Intracellular hyaluronan-binding protein 4 Q5JVS0 343-358 SHVFR+KPANDITSQLE N MS His Val Phe Arg Lys Pro Ala Asn Barré et al., 2014
Keratin, type I cytoskeletal 18 P05783 182-200 IHGLR+KVIDDTNITRLQLE N MS His Gly Leu Arg Lys Val Ile Asp Barré et al., 2014
KH domain-containing, RNA-binding, signal transduction-associated protein 1 Q07666 280-364 peptide-Arg348+Thr-peptide N MS Pro Arg Ala Arg Thr Ala Gly Ile Barré et al., 2014
L-lactate dehydrogenase B chain P07195 288-313 peptide-Arg299+Gly-peptide N MS Leu Asn Ala Arg Gly Leu Thr Ser Barré et al., 2014
Low molecular weight phosphotyrosine protein phosphatase Q53RU0 25-38 AVFR+KLVTDQNISE N MS Ala Val Phe Arg Lys Leu Val Thr Barré et al., 2014
Macrophage migration inhibitory factor P14174 56-86 peptide-Arg74+Ser-peptide N MS Ala Gln Asn Arg Ser Tyr Ser Lys Barré et al., 2014
Matrix-remodeling-associated protein 7 P84157 138-161 peptide-Arg149+Gly-peptide N MS Gly Lys Leu Arg Gly Asn Gln Tyr Barré et al., 2014
Mitochondrial import inner membrane translocase subunit Tim13 Q9Y5L4 45-62 KCFR+KCIGKPGGSLDNSE N MS Lys Cys Phe Arg Lys Cys Ile Gly Barré et al., 2014
Myosin regulatory light chain 12B O14950 146-158 APIDKKGNFNYIEFTRILKHGAKDKD+EAPIDKKGNFNYIE N MS Lys Asp Lys Asp Glu Ala Pro Ile Barré et al., 2014
Nascent polypeptide-associated complex subunit alpha-2 Q9H009 181-212 peptide-Arg197+Ala-peptide N MS Lys Ala Val Arg Ala Leu Lys Asn Barré et al., 2014
Nuclear migration protein nudC Q9Y266 28-48 LVNTFFSFLR+RKTDFFIGGEE N MS Ser Phe Leu Arg Arg Lys Thr Asp Barré et al., 2014
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 Q9H1E3 2-18 SRPVRNR+KVVDYSQFQE N MS Val Arg Asn Arg Lys Val Val Asp Barré et al., 2014
Nucleoside diphosphate kinase A P15531 30-45 QKGFR+LVGLKFMQASE N MS Lys Gly Phe Arg Leu Val Gly Leu Barré et al., 2014
Paraspeckle component 1 Q8WXF1 2-13 MLR+GNLKQVRIE N MS - Met Leu Arg Gly Asn Leu Lys Barré et al., 2014
Peroxiredoxin-1 Q06830 156-171 TLR+LVQAFQFTDKHGE N MS - Thr Leu Arg Leu Val Gln Ala Barré et al., 2014
Phenylalanine--tRNA ligase beta subunit Q9NSD9 551-573 peptide-Arg554+Gly-peptide N MS Ile Phe Ala Arg Gly Gln Ser Val Barré et al., 2014
Phosphoglycerate kinase 1 P00558 149-164 AFR+ASLSKLGDVYVND N MS - Ala Phe Arg Ala Ser Leu Ser Barré et al., 2014
Phosphoglycerate kinase 1 P00558 327-344 AVTR+AKQIVWNGPVGVFE N MS Ala Val Thr Arg Ala Lys Gln Ile Barré et al., 2014
Plasminogen activator inhibitor 1 RNA-binding protein Q9Y367 78-94 R+KNPLPPSVGVVDKKEE N MS - - - Arg Lys Asn Pro Leu Barré et al., 2014
Polypyrimidine tract-binding protein 1 P26599 51-72 peptide-Arg59+Val-peptide N MS Val Pro Ser Arg Val Ile His Ile Barré et al., 2014
PRA1 family protein 3 O75915 175-188 GINR+LTDYISKVKE N MS Gly Ile Asn Arg Leu Thr Asp Tyr Barré et al., 2014
Prefoldin subunit 1 O60925 63-74 GVGR+MFILQSKE N MS Gly Val Gly Arg Met Phe Ile Leu Barré et al., 2014
Prelamin-A/C Q5TCJ2 292-317 peptide-Arg296+Ile-peptide N MS Gln Gln Ser Arg Ile Arg Ile Asp Barré et al., 2014
Probable rRNA-processing protein EBP2 Q99848 26-41 AFSR+GLLKPGLNVVLE N MS Ala Phe Ser Arg Gly Leu Leu Lys Barré et al., 2014
Prohibitin-2 Q99623 286-299 SFTR+GSDSLIKGKK N MS Ser Phe Thr Arg Gly Ser Asp Ser Barré et al., 2014
Proliferation-associated protein 2G4 Q9UQ80 152-168 AALR+LVKPGNQNTQVTE N MS Ala Ala Leu Arg Leu Val Lys Pro Barré et al., 2014
Proteasome subunit alpha type-2 P25787 216-234 AGFR+RLTPTEVKDYLAAIA N MS Ala Gly Phe Arg Arg Leu Thr Pro Barré et al., 2014
Protein disulfide-isomerase A3 P30101 69-84 AAATR+LKGIVPLAKVD N MS Ala Ala Thr Arg Leu Lys Gly Ile Barré et al., 2014
Protein disulfide-isomerase A6 Q99778 138-164 peptide-Arg153+Ser-peptide N MS Lys Gln Gly Arg Ser Asp Ser Ser Barré et al., 2014
Protein DJ-1 Q99497 2-16 ASKR+ALVILAKGAEE N MS Ala Ser Lys Arg Ala Leu Val Ile Barré et al., 2014
Putative heat shock protein HSP 90-alpha A2 Q14568 179-192 RMGR+GTKVILHLKE N MS Arg Met Gly Arg Gly Thr Lys Val Barré et al., 2014
Ribonucleoprotein PTB-binding 1 Q8IY67 428-451 peptide-Arg431+Arg-peptide N MS Leu Pro Pro Arg Arg Gly Lys Pro Barré et al., 2014
Ribosomal L1 domain-containing protein 1 O76021 302-324 peptide-Arg310+Lys-peptide N MS Gln Gln Ala Arg Lys Thr Ala Ser Barré et al., 2014
RNA-binding protein 25 Q9UEQ5 244-262 IFR+RFPVAPLIPYPLITKE N MS - Ile Phe Arg Arg Phe Pro Val Barré et al., 2014
Serine/arginine-rich splicing factor 1 Q07955 16-33 CR+IYVGNLPPDIRTKDIE N MS - - Cys Arg Ile Tyr Val Gly Barré et al., 2014
Serine/threonine-protein kinase PAK 3 Q7Z2E4 112-126 QWAR+LLQTSNITKLE N MS Gln Trp Ala Arg Leu Leu Gln Thr Barré et al., 2014
Suc-Ala-Ala-Pro-Arg-NHPhNO2 Suc-Ala-Ala-Pro-Arg+NHPhNO2 S Ala Ala Pro Arg NAN - - - Hobson et al., 2004
Suc-Ala-Ala-Pro-Lys-NHPhNO2 Suc-Ala-Ala-Pro-Lys+NHPhNO2 S Ala Ala Pro Lys NAN - - - Hobson et al., 2004
T-complex protein 1 subunit delta P50991 47-63 AIR+TSLGPKGMDKMIQD N MS - Ala Ile Arg Thr Ser Leu Gly Barré et al., 2014
T-complex protein 1 subunit delta P50991 525-539 TVR+SILKIDDVVNTR N MS - Thr Val Arg Ser Ile Leu Lys Barré et al., 2014
T-complex protein 1 subunit eta Q99832 392-413 peptide-Arg397+Arg-peptide N MS Met Ile Val Arg Arg Ala Ile Lys Barré et al., 2014
Targeting protein for Xklp2 Q9ULW0 43-84 peptide-Arg62+Lys-peptide N MS Thr Pro Leu Arg Lys Ala Asn Leu Barré et al., 2014
Thioredoxin-dependent peroxide reductase, mitochondrial Q96HK4 212-223 TLR+LVKAFQYVE N MS - Thr Leu Arg Leu Val Lys Ala Barré et al., 2014
Transcription elongation regulator 1 O14776 810-822 SQSR+WSKVKDKVE N MS Ser Gln Ser Arg Trp Ser Lys Val Barré et al., 2014
Transitional endoplasmic reticulum ATPase P55072 651-673 peptide-Arg662+Lys-peptide N MS Ala Asn Leu Arg Lys Ser Pro Val Barré et al., 2014
Transketolase P29401 611-623 AIAQAVRGLITK+DAIAQAVRGLITKA N MS Leu Ile Thr Lys Asp Ala Ile Ala Barré et al., 2014
Transketolase P29401 334-349 R+IIALDGDTKNSTFSE N MS - - - Arg Ile Ile Ala Leu Barré et al., 2014
Tubulin alpha-4A chain P68366 56-77 peptide-Arg64+Ala-peptide N MS His Val Pro Arg Ala Val Phe Val Barré et al., 2014
Tyrosine--tRNA ligase, cytoplasmic P54577 399-414 PR+TVVSGLVQFVPKEE N MS - - Pro Arg Thr Val Val Ser Barré et al., 2014
Ubiquitin-40S ribosomal protein S27a Q9UEG1 53-64 GR+TLSDYNIQKE N MS - - Gly Arg Thr Leu Ser Asp Barré et al., 2014
Uncharacterized protein CXorf57 Q9H7W5 576-592 TLR+NANRPSTSQAARVE N MS - Thr Leu Arg Asn Ala Asn Arg Barré et al., 2014
Vimentin Q8N850 113-125 R+FANYIDKVRFLE N MS - - - Arg Phe Ala Asn Tyr Barré et al., 2014
Vimentin Q8N850 157-172 LRR+QVDQLTNDKARVE N MS - Leu Arg Arg Gln Val Asp Gln Barré et al., 2014
Vinculin P18206 820-833 SGYR+ILGAVAKVRE N MS Ser Gly Tyr Arg Ile Leu Gly Ala Barré et al., 2014
Z-Phe-Val-Arg-NHPhNO2 Z-Phe-Val-Arg+NHPhNO2 S Z Phe Val Arg NAN - - - Hobson et al., 2004

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