Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P55072

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-806	P		NT	<%Agarwal et al., 2012[]%>
74	caspase-6	2-806	P			Klaiman et al., 2008
95	trypsin 1	2-806	N		MS	Schilling & Overall, 2008
109	trypsin 1	2-806	N		MS	Schilling & Overall, 2008
169	caspase-6	2-806	P			Klaiman et al., 2008
179	caspase-6	2-806	P			Klaiman et al., 2008
204	caspase-6	2-806	P			Klaiman et al., 2008
240	matrix metallopeptidase-2	221-261	N		MS	Schilling & Overall, 2008
261	glutamyl endopeptidase I	2-806	N		MS	Schilling & Overall, 2008
277	trypsin 1	2-806	N		MS	Schilling & Overall, 2008
287	trypsin 1	2-806	N		MS	Schilling & Overall, 2008
299	matrix metallopeptidase-2	295-312	N		MS	Schilling & Overall, 2008
300	matrix metallopeptidase-2	295-312	N		MS	Schilling & Overall, 2008
307	caspase-3	2-806	P	normal turnover		Jang et al., 2008
307	caspase-7	2-806	P			Jang et al., 2008
307	caspase-6	2-806	P			Klaiman et al., 2008
312	trypsin 1	2-806	N		MS	Schilling & Overall, 2008
323	trypsin 1	2-806	N		MS	Schilling & Overall, 2008
336	trypsin 1	2-806	N		MS	Schilling & Overall, 2008
368	caspase-6	2-806	P			Klaiman et al., 2008
377	trypsin 1	2-806	N		MS	Schilling & Overall, 2008
386	trypsin 1	2-806	N		MS	Schilling & Overall, 2008
395	caspase-6	2-806	P			Klaiman et al., 2008
397	cathepsin S	390-408	N		MS	Biniossek et al., 2011
410	caspase-6	2-806	P			Klaiman et al., 2008
411	HIV-1 retropepsin	389-424	N		MS	Schilling & Overall, 2008
413	matrix metallopeptidase-2	389-424	N		MS	Schilling & Overall, 2008
422	matrix metallopeptidase-2	417-433	N		MS	Schilling & Overall, 2008
424	trypsin 1	2-806	N		MS	Schilling & Overall, 2008
433	glutamyl endopeptidase I	2-806	N		MS	Schilling & Overall, 2008
450	caspase-6	2-806	P			Klaiman et al., 2008
465	trypsin 1	2-806	N		MS	Schilling & Overall, 2008
486	trypsin 1	2-806	N		MS	Schilling & Overall, 2008
487	trypsin 1	2-806	N		MS	Schilling & Overall, 2008
491	matrix metallopeptidase-2	487-502	N		MS	Schilling & Overall, 2008
491	glutamyl endopeptidase I	487-505	N		MS	Schilling & Overall, 2008
492	HIV-1 retropepsin	487-502	N		MS	Schilling & Overall, 2008
493	elastase-2	487-505	N		MS	Schilling & Overall, 2008
494	cathepsin L	488-502	N		MS	Biniossek et al., 2011
494	meprin alpha subunit	493-517	N		NT	Bertenshaw et al., 2001
494	meprin beta subunit	491-505	N		MS	Becker-Pauly et al., 2011
494	LAST_MAM peptidase (Limulus-type)	491-505	N		MS	Becker-Pauly et al., 2011
494	unknown peptidase	493-517	N			Bertenshaw et al., 2001
502	trypsin 1	2-806	N		MS	Schilling & Overall, 2008
503	meprin alpha subunit	493-517	N		NT	Bertenshaw et al., 2001
503	chymotrypsin A (cattle-type)	2-806	N		MS	Schilling & Overall, 2008
503	unknown peptidase	493-517	N			Bertenshaw et al., 2001
504	meprin alpha subunit	493-517	N		NT	Bertenshaw et al., 2001
504	unknown peptidase	493-517	N			Bertenshaw et al., 2001
505	meprin alpha subunit	493-517	N		NT	Bertenshaw et al., 2001
505	trypsin 1	2-806	N		MS	Schilling & Overall, 2008
505	unknown peptidase	493-517	N			Bertenshaw et al., 2001
506	meprin alpha subunit	493-517	N		NT	Bertenshaw et al., 2001
506	unknown peptidase	493-517	N			Bertenshaw et al., 2001
507	meprin alpha subunit	493-517	N		NT	Bertenshaw et al., 2001
507	unknown peptidase	493-517	N			Bertenshaw et al., 2001
508	meprin alpha subunit	493-517	N		NT	Bertenshaw et al., 2001
509	unknown peptidase	493-517	N			Bertenshaw et al., 2001
512	trypsin 1	2-806	N		MS	Schilling & Overall, 2008
515	meprin alpha subunit	493-517	N		NT	Bertenshaw et al., 2001
515	unknown peptidase	493-517	N			Bertenshaw et al., 2001
524	trypsin 1	2-806	N		MS	Schilling & Overall, 2008
567	trypsin 1	2-806	N		MS	Schilling & Overall, 2008
571	matrix metallopeptidase-2	567-584	N		MS	Schilling & Overall, 2008
580	caspase-3	2-806	P	normal turnover		Jang et al., 2008
580	caspase-7	2-806	P			Jang et al., 2008
580	caspase-6	2-806	P			Klaiman et al., 2008
584	trypsin 1	2-806	N		MS	Schilling & Overall, 2008
609	caspase-6	2-806	P			Klaiman et al., 2008
638	trypsin 1	2-806	N		MS	Schilling & Overall, 2008
641	HIV-1 retropepsin	638-651	N		MS	Schilling & Overall, 2008
651	trypsin 1	2-806	N		MS	Schilling & Overall, 2008
668	trypsin 1	2-806	N		MS	Schilling & Overall, 2008
669	caspase-6	2-806	P			Klaiman et al., 2008
677	trypsin 1	2-806	N		MS	Schilling & Overall, 2008
683	cathepsin S	678-693	N		MS	Biniossek et al., 2011
693	thrombin	689-701	N		MS	Schilling & Overall, 2008
701	glutamyl endopeptidase I	2-806	N		MS	Schilling & Overall, 2008
713	granzyme K	2-806	P		NT	Guo et al., 2010
725	caspase-6	2-806	P			Klaiman et al., 2008
726	caspase-6	2-806	P			Klaiman et al., 2008
756	glutamyl endopeptidase I	754-766	N		MS	Schilling & Overall, 2008
757	HIV-1 retropepsin	754-766	N		MS	Schilling & Overall, 2008
766	trypsin 1	2-806	N		MS	Schilling & Overall, 2008
801	caspase-6	2-806	P			Klaiman et al., 2008