Summary for peptidase S01.021: DESC1 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS NameDESC1 peptidase
Other namesDESC1 protease, Differentially Expressed in Squamous cell Carcinoma-1 protein, Mername-AA170 peptidase
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.021
HolotypeDESC1 peptidase (Mus musculus), Uniprot accession Q5S248 (peptidase unit: 211-442), MERNUM MER0021883
History Identifier created: MEROPS 4.0 (27 January 2000)
Activity
Catalytic typeSerine
NC-IUBMBNot yet included in IUBMB recommendations.
Activity statushuman: putative
mouse: active (Hobson, 2004)
Other databases TREEFAMhttp://www.treefam.org/family/TF351684
PANTHERhttp://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR43957:SF9
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/RScissile bond-/v/-/- (based on 108 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 10 6 7 0 14 1 21 16
Pro 2 5 9 0 0 2 5 8
Ala 14 15 15 0 6 17 5 7
Val 2 6 6 0 14 25 11 8
Leu 3 3 16 0 13 15 10 7
Ile 4 9 2 0 5 8 7 11
Met 1 2 1 0 1 1 3 1
Phe 1 6 10 0 1 7 1 3
Tyr 0 2 2 0 2 4 2 3
Trp 1 1 0 0 1 0 0 0
Ser 8 3 9 0 9 5 5 7
Thr 3 9 7 0 5 5 5 7
Cys 0 1 2 0 2 2 0 0
Asn 3 2 5 0 4 4 3 3
Gln 5 12 0 0 2 3 8 2
Asp 0 0 0 0 1 1 5 6
Glu 0 1 0 0 1 0 0 1
Lys 5 4 3 1 15 3 10 13
Arg 13 7 4 105 7 1 1 1
His 3 1 1 0 1 0 2 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
TMPRSS11E 4q13.3 ENSG00000173487 28983
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Tmprss11e 5:E1 ENSMUSG00000054537 243084 MGI:3513175