$VAR1 = undef;

Summary for peptidase S01.021: DESC1 peptidase

Names
MEROPS Name	DESC1 peptidase
Other names	DESC1 protease, Differentially Expressed in Squamous cell Carcinoma-1 protein, Mername-AA170 peptidase, TMPRSS11E

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.021
Holotype	DESC1 peptidase (Mus musculus), Uniprot accession Q5S248 (peptidase unit: 211-442), MERNUM MER0021883
History	Identifier created: MEROPS 4.0 (27 January 2000)

Activity
Catalytic type	Serine
NC-IUBMB	Not yet included in IUBMB recommendations.
Activity status	human: putative mouse: active (Hobson, 2004)
Other databases	TREEFAM	http://www.treefam.org/family/TF351684
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/R-/v/-/- (based on 111 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	11	6	7	0	14	1	21	16
Pro	3	5	9	0	0	2	6	8
Ala	14	15	17	0	7	17	5	8
Val	2	6	7	0	14	25	11	9
Leu	4	3	16	0	13	16	11	7
Ile	4	10	2	0	5	8	8	11
Met	1	2	1	0	1	1	3	1
Phe	1	6	10	0	1	7	1	3
Tyr	0	2	2	0	2	4	2	3
Trp	1	1	0	0	1	0	0	0
Ser	8	4	9	0	10	5	5	8
Thr	3	9	8	0	6	5	5	7
Cys	0	1	2	0	2	2	0	0
Asn	3	3	5	0	4	4	3	3
Gln	5	12	0	0	2	4	8	2
Asp	0	1	0	1	1	1	5	6
Glu	0	1	0	0	1	0	0	1
Lys	6	4	4	2	15	3	10	13
Arg	13	7	4	108	7	2	1	1
His	3	1	1	0	1	0	2	0