Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence Q99848

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
21	granzyme A	1-306	N			Van Damme et al., 2010
29	thrombin	25-41	N		MS	Schilling & Overall, 2008
30	matrix metallopeptidase-2	25-41	N		MS	Schilling & Overall, 2008
35	cathepsin B	30-44	N		MS	Biniossek et al., 2011
41	glutamyl endopeptidase I	1-306	N		MS	Schilling & Overall, 2008
81	cathepsin S	70-90	N		MS	Biniossek et al., 2011
83	granzyme B (Homo sapiens-type)	1-306	N		MS	Van Damme et al., 2010
91	granzyme A	1-306	N			Van Damme et al., 2010
163	granzyme A	1-306	N			Van Damme et al., 2010
208	granzyme B, rodent-type	1-306	N		MS	Van Damme et al., 2009