Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P01023

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
23	unknown peptidase	1-1474	P	release of a signal peptide	NT	Sottrup-Jensen et al., 1984
163	leucurolysin-a	24-1474	N		MS	Paes Leme et al., 2010
324	atrolysin C	24-1474	N		MS	Paes Leme et al., 2010
324	BaP1 peptidase (Bothrops asper)	24-1474	N		MS	Paes Leme et al., 2010
325	bothropasin	24-1474	N		MS	Paes Leme et al., 2010
616	atrolysin C	24-1474	N		MS	Paes Leme et al., 2010
616	BaP1 peptidase (Bothrops asper)	24-1474	N		MS	Paes Leme et al., 2010
617	bothropasin	24-1474	N		MS	Paes Leme et al., 2010
702	matrix metallopeptidase-1	24-1474	P			Cawston, 2004
702	matrix metallopeptidase-2	24-1474	P			Arbelaez et al., 1997
702	matrix metallopeptidase-9	24-1474	P			Arbelez et al., 1997
702	matrix metallopeptidase-3	24-1474	P			Enghild et al., 1989
702	lebetase	24-1474	N			Siigur & Siigur, 2004
704	papain	24-1474	P	normal turnover		Mortensen et al., 1981
704	trypsin (Streptomyces griseus-type)	24-1474	P			Mortensen et al., 1981
704	trypsin 1	24-1474	P	springing of a trap mechanism		Mortensen et al., 1981
705	elastase-1	24-1474	P			Mortensen et al., 1981
706	papain	24-1474	P	normal turnover		Mortensen et al., 1981
706	elastase-1	24-1474	P			Mortensen et al., 1981
707	chymosin	24-1474	P	normal turnover		Mortensen et al., 1981
707	HIV-1 retropepsin	24-1474	N	pathological turnover		Meier et al., 1991
707	matrix metallopeptidase-3	24-1474	P	normal turnover		Mast et al., 1991
707	chymase (Homo sapiens-type)	24-1474	P			Walter et al., 1999
708	chymotrypsin A (cattle-type)	24-1474	P			Mortensen et al., 1981
708	chymase (Homo sapiens-type)	24-1474	P			Walter et al., 1999
709	glutamyl endopeptidase I	24-1474	P			Mortensen et al., 1981
710	procollagen C-peptidase	24-1474	P			Zhang et al., 2006
712	atrolysin E	24-1474	N			Fox & Bjarnason, 2004
713	ADAMTS4 peptidase	24-1474	P			Tortorella et al., 2004
713	ADAMTS5 peptidase	24-1474	P			Tortorella et al., 2004
716	atrolysin E	24-1474	N			Fox & Bjarnason, 2004
717	atrolysin A	24-1474	N			Fox & Bjarnason, 2004
717	lebetase	24-1474	N			Siigur & Siigur, 2004
719	thermolysin	24-1474	N			Mortensen et al., 1981
719	matrix metallopeptidase-2	24-1474	P	springing of a trap mechanism		Arbelaez et al., 1997
719	jararhagin	24-1474	N			Anai et al., 1998
719	atrolysin A	24-1474	N			Fox & Bjarnason, 2004
719	atrolysin C	24-1474	N			Fox, 2004
719	mutalysin II	716-727	N			<%Sanchez, 2012[]%>
719	lebetase	24-1474	N			Siigur & Siigur, 2004
719	trypsin (Streptomyces griseus-type)	24-1474	P			Mortensen et al., 1981
719	trypsin 1	24-1474	P	springing of a trap mechanism		Mortensen et al., 1981
719	thrombin	24-1474	P	springing of a trap mechanism		Mortensen et al., 1981
719	plasmin	24-1474	P			Mortensen et al., 1981
719	subtilisin Carlsberg	24-1474	P			Mortensen et al., 1981
719	subtilisin BPN'	24-1474	P			Mortensen et al., 1981
720	streptogrisin B	24-1474	P			Mortensen et al., 1981
720	subtilisin Carlsberg	24-1474	P			Mortensen et al., 1981
720	subtilisin BPN'	24-1474	P			Mortensen et al., 1981
722	papain	24-1474	P	normal turnover		Mortensen et al., 1981
730	thermolysin	24-1474	N			Mortensen et al., 1981
731	chymosin	24-1474	P	normal turnover		Mortensen et al., 1981
734	chymosin	24-1474	P	normal turnover		Mortensen et al., 1981
832	atrolysin C	24-1474	N		MS	Paes Leme et al., 2010
833	atrolysin C	24-1474	N		MS	Paes Leme et al., 2010
833	BaP1 peptidase (Bothrops asper)	24-1474	N		MS	Paes Leme et al., 2010
834	cathepsin E	24-1474	P	normal turnover		Yasuda et al., 2005
881	bothropasin	24-1474	N		MS	Paes Leme et al., 2010
881	BaP1 peptidase (Bothrops asper)	24-1474	N		MS	Paes Leme et al., 2010
902	BaP1 peptidase (Bothrops asper)	24-1474	N		MS	Paes Leme et al., 2010
993	BaP1 peptidase (Bothrops asper)	24-1474	N		MS	Paes Leme et al., 2010
1108	atrolysin C	24-1474	N		MS	Paes Leme et al., 2010
1109	leucurolysin-a	24-1474	N		MS	Paes Leme et al., 2010
1113	atrolysin C	24-1474	N		MS	Paes Leme et al., 2010
1113	BaP1 peptidase (Bothrops asper)	24-1474	N		MS	Paes Leme et al., 2010
1321	atrolysin C	24-1474	N		MS	Paes Leme et al., 2010
1413	atrolysin C	24-1474	N		MS	Paes Leme et al., 2010
1413	BaP1 peptidase (Bothrops asper)	24-1474	N		MS	Paes Leme et al., 2010
1413	leucurolysin-a	24-1474	N		MS	Paes Leme et al., 2010
1414	bothropasin	24-1474	N		MS	Paes Leme et al., 2010
1428	bothropasin	24-1474	N		MS	Paes Leme et al., 2010
1430	bothropasin	24-1474	N		MS	Paes Leme et al., 2010
1430	leucurolysin-a	24-1474	N		MS	Paes Leme et al., 2010
1457	BaP1 peptidase (Bothrops asper)	24-1474	N		MS	Paes Leme et al., 2010