Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Substrates for peptidase M12.140: bothropasin

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
alpha-1-peptidase inhibitor P01009 25-418 peptide-Ala166+Phe-peptide N MS His Ser Glu Ala Phe Thr Val Asn Paes Leme et al., 2010
alpha-1-peptidase inhibitor P01009 25-418 peptide-Glu290+Leu-peptide N MS Leu Glu Asn Glu Leu Thr His Asp Paes Leme et al., 2010
alpha-1-peptidase inhibitor P01009 25-418 peptide-Ala274+Ile-peptide N MS Asn Ala Thr Ala Ile Phe Phe Leu Paes Leme et al., 2010
alpha-1-peptidase inhibitor P01009 25-418 peptide-Leu142+Phe-peptide N MS Gly Asn Gly Leu Phe Leu Ser Glu Paes Leme et al., 2010
alpha-2-macroglobulin P01023 24-1474 peptide-Phe1430+Phe-peptide N MS Leu Ser Leu Phe Phe Thr Val Leu Paes Leme et al., 2010
alpha-2-macroglobulin P01023 24-1474 peptide-Gln325+Ile-peptide N MS Thr Glu Ala Gln Ile Gln Glu Glu Paes Leme et al., 2010
alpha-2-macroglobulin P01023 24-1474 peptide-Glu881+Leu-peptide N MS Glu Ser Gln Glu Leu Cys Gly Thr Paes Leme et al., 2010
alpha-2-macroglobulin P01023 24-1474 peptide-His1414+Val-peptide N MS Ser Ser Asn His Val Leu Ile Tyr Paes Leme et al., 2010
alpha-2-macroglobulin P01023 24-1474 peptide-Ser617+Val-peptide N MS Ser Ala Ser Ser Val Tyr Asn Leu Paes Leme et al., 2010
alpha-2-macroglobulin P01023 24-1474 peptide-Ser1428+Leu-peptide N MS Gln Thr Leu Ser Leu Phe Phe Thr Paes Leme et al., 2010
ceruloplasmin P00450 20-1065 peptide-Ser405+Ala-peptide N MS Gly Ser Asp Ser Ala Val Phe Phe Paes Leme et al., 2010
ceruloplasmin P00450 20-1065 peptide-Ser590+Leu-peptide N MS Glu Asn Glu Ser Leu Leu Leu Glu Paes Leme et al., 2010
ceruloplasmin P00450 20-1065 peptide-Pro451+Val-peptide N MS Ile Leu Gly Pro Val Ile Trp Ala Paes Leme et al., 2010
fLJ00385 protein Q8NF17 1-509 peptide-Pro231+Ser-peptide N MS Leu Gly Gly Pro Ser Val Phe Leu Paes Leme et al., 2010
fLJ00385 protein Q8NF17 1-509 peptide-Ser357+Leu-peptide N MS Asn Gln Val Ser Leu Thr Cys Leu Paes Leme et al., 2010
fLJ00385 protein Q8NF17 1-509 peptide-Gly274+Val-peptide N MS Tyr Val Asp Gly Val Glu Val His Paes Leme et al., 2010
ig lambda-2 chain C regions P0CG05 1-106 peptide-Tyr71+Leu-peptide N MS Ala Ser Ser Tyr Leu Ser Leu Thr Paes Leme et al., 2010
ig lambda-2 chain C regions P0CG05 1-106 peptide-Gln88+Val-peptide N MS Tyr Ser Cys Gln Val Thr His Glu Paes Leme et al., 2010
ig lambda-2 chain C regions P0CG05 1-106 peptide-Ser70+Tyr-peptide N MS Ala Ala Ser Ser Tyr Leu Ser Leu Paes Leme et al., 2010
ig lambda-2 chain C regions P0CG05 1-106 peptide-Ala37+Val-peptide N MS Tyr Pro Gly Ala Val Thr Val Ala Paes Leme et al., 2010
ig mu heavy chain disease protein P04220 1-391 peptide-Val352+Val-peptide N MS Tyr Thr Cys Val Val Ala His Glu Paes Leme et al., 2010
ig mu heavy chain disease protein P04220 1-391 peptide-Ser192+Val-peptide N MS Thr Tyr Asp Ser Val Thr Ile Ser Paes Leme et al., 2010
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His+Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Val Asn Gln His Leu Cya Gly Ser Fox et al., 1986
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala+Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Leu Val Glu Ala Leu Tyr Leu Val Fox et al., 1986
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe+Phe-Tyr-Thr-Pro-Lys-Ala N Glu Arg Gly Phe Phe Tyr Thr Pro Fox et al., 1986
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr+Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Glu Ala Leu Tyr Leu Val Cya Gly Fox et al., 1986
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His+Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Cya Gly Ser His Leu Val Glu Ala Fox et al., 1986
plasminogen P00747 20-810 peptide-Ser460+Val-peptide P NT Thr Glu Ala Ser Val Val Ala Pro Ho et al., 2001
putative uncharacterized protein Q8TCD0 1-239 peptide-Cys159+Leu-peptide N MS Ser Val Val Cys Leu Leu Asn Asn Paes Leme et al., 2010
putative uncharacterized protein Q8TCD0 1-239 peptide-Ala178+Leu-peptide N MS Val Asp Asn Ala Leu Gln Ser Gly Paes Leme et al., 2010
putative uncharacterized protein Q8TCD0 1-239 peptide-Gly225+Leu-peptide N MS Thr His Gln Gly Leu Ser Ser Pro Paes Leme et al., 2010
putative uncharacterized protein Q8TCD0 1-239 peptide-Pro138+Ser-peptide N MS Val Ala Ala Pro Ser Val Phe Ile Paes Leme et al., 2010
putative uncharacterized protein Q8TCD0 1-239 peptide-Leu160+Leu-peptide N MS Val Val Cys Leu Leu Asn Asn Phe Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-Ser389+Ala-peptide N MS Glu Cys Val Ser Ala Glu Thr Thr Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-Leu262+Ala-peptide N MS Asp Cys His Leu Ala Gln Val Pro Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-Tyr445+Phe-peptide N MS Glu Ala Gly Tyr Phe Ala Ile Ala Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-Gly413+Phe-peptide N MS Leu Asp Gly Gly Phe Val Tyr Ile Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-Cys260+His-peptide N MS Tyr Lys Asp Cys His Leu Ala Gln Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-Leu244+Leu-peptide N MS Gln Tyr Glu Leu Leu Cys Leu Asp Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-Ser409+Leu-peptide N MS Asp Ala Met Ser Leu Asp Gly Gly Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-Glu243+Leu-peptide N MS Asp Gln Tyr Glu Leu Leu Cys Leu Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-Ser688+Leu-peptide N MS Ser Thr Ser Ser Leu Leu Glu Ala Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-Gly152+Leu-peptide N MS Ile Pro Ile Gly Leu Leu Tyr Cys Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-Leu153+Leu-peptide N MS Pro Ile Gly Leu Leu Tyr Cys Asp Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-Phe414+Val-peptide N MS Asp Gly Gly Phe Val Tyr Ile Ala Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-His261+Leu-peptide N MS Lys Asp Cys His Leu Ala Gln Val Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-Glu284+Leu-peptide N MS Leu Ile Trp Glu Leu Leu Asn Gln Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-Gly521+Leu-peptide N MS Met Gly Ser Gly Leu Asn Leu Cys Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-Leu285+Leu-peptide N MS Ile Trp Glu Leu Leu Asn Gln Ala Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-Asp457+Leu-peptide N MS Ser Ala Ser Asp Leu Thr Trp Asp Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-Asp577+Tyr-peptide N MS Asn Glu Lys Asp Tyr Glu Leu Leu Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-Gly335+Tyr-peptide N MS Met Tyr Leu Gly Tyr Glu Tyr Val Paes Leme et al., 2010
serum albumin Q56G89 1-609 peptide-Thr149+Ala-peptide N MS Val Met Cys Thr Ala Phe His Asp Paes Leme et al., 2010
serum albumin Q56G89 1-609 peptide-Met353+Phe-peptide N MS Phe Leu Gly Met Phe Leu Tyr Glu Paes Leme et al., 2010
serum albumin Q56G89 1-609 peptide-Gln483+Leu-peptide N MS Phe Leu Asn Gln Leu Cys Val Leu Paes Leme et al., 2010
serum albumin Q56G89 1-609 peptide-Ala514+Leu-peptide N MS Cys Phe Ser Ala Leu Glu Val Asp Paes Leme et al., 2010
serum albumin Q56G89 1-609 peptide-Glu417+Leu-peptide N MS Gln Asn Cys Glu Leu Phe Glu Gln Paes Leme et al., 2010
serum albumin Q56G89 1-609 peptide-Asp273+Leu-peptide N MS Cys His Gly Asp Leu Leu Glu Cys Paes Leme et al., 2010
serum albumin Q56G89 1-609 peptide-Ala552+Leu-peptide N MS Lys Gln Thr Ala Leu Val Glu Leu Paes Leme et al., 2010
vitamin D-binding protein P02774 17-474 peptide-Pro253+Leu-peptide N MS Asp Val Leu Pro Leu Ala Glu Asp Paes Leme et al., 2010
vitamin D-binding protein P02774 17-474 peptide-Ser210+Leu-peptide N MS Lys His Leu Ser Leu Leu Thr Thr Paes Leme et al., 2010
zinc metalloproteinase-disintegrin bothropasin O93523 192-610 peptide-Pro394+Leu-peptide P NT Leu Asn Glu Pro Leu Gly Thr Asp Assakura et al., 2003

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use