Substrates for peptidase M12.327: leucurolysin-a

Summary Alignment Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
alpha-2-macroglobulin	P01023	24-1474	peptide-Phe1430+Phe-peptide	N	MS	Leu	Ser	Leu	Phe	Phe	Thr	Val	Leu	Paes Leme et al., 2011
alpha-2-macroglobulin	P01023	24-1474	peptide-Asn1413+His-peptide	N	MS	Val	Ser	Ser	Asn	His	Val	Leu	Ile	Paes Leme et al., 2011
alpha-2-macroglobulin	P01023	24-1474	peptide-Leu1109+Leu-peptide	N	MS	Thr	Ile	Ala	Leu	Leu	Glu	Ile	Pro	Paes Leme et al., 2011
alpha-2-macroglobulin	P01023	24-1474	peptide-Pro163+Leu-peptide	N	MS	Glu	Leu	Ile	Pro	Leu	Val	Tyr	Ile	Paes Leme et al., 2011
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala+Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N		Leu	Val	Glu	Ala	Leu	Tyr	Leu	Val	Bello et al., 2006
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr+Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N		Glu	Ala	Leu	Tyr	Leu	Val	Cya	Gly	Bello et al., 2006
putative uncharacterized protein	Q8TCD0	1-239	peptide-Cys159+Leu-peptide	N	MS	Ser	Val	Val	Cys	Leu	Leu	Asn	Asn	Paes Leme et al., 2011
putative uncharacterized protein	Q8TCD0	1-239	peptide-Leu160+Leu-peptide	N	MS	Val	Val	Cys	Leu	Leu	Asn	Asn	Phe	Paes Leme et al., 2011
putative uncharacterized protein	Q8TCD0	1-239	peptide-His223+Gln-peptide	N	MS	Glu	Val	Thr	His	Gln	Gly	Leu	Ser	Paes Leme et al., 2011
putative uncharacterized protein	Q8TCD0	1-239	peptide-Pro138+Ser-peptide	N	MS	Val	Ala	Ala	Pro	Ser	Val	Phe	Ile	Paes Leme et al., 2011
serotransferrin	P02787	20-698	peptide-Tyr115+Ala-peptide	N	MS	Thr	Phe	Tyr	Tyr	Ala	Val	Ala	Val	Paes Leme et al., 2011
serotransferrin	P02787	20-698	peptide-Thr112+Phe-peptide	N	MS	Asp	Pro	Gln	Thr	Phe	Tyr	Tyr	Ala	Paes Leme et al., 2011
serotransferrin	P02787	20-698	peptide-Cys260+His-peptide	N	MS	Tyr	Lys	Asp	Cys	His	Leu	Ala	Gln	Paes Leme et al., 2011
serotransferrin	P02787	20-698	peptide-Leu580+Leu-peptide	N	MS	Asp	Tyr	Glu	Leu	Leu	Cys	Leu	Asp	Paes Leme et al., 2011
serotransferrin	P02787	20-698	peptide-Leu244+Leu-peptide	N	MS	Gln	Tyr	Glu	Leu	Leu	Cys	Leu	Asp	Paes Leme et al., 2011
serotransferrin	P02787	20-698	peptide-Gly152+Leu-peptide	N	MS	Ile	Pro	Ile	Gly	Leu	Leu	Tyr	Cys	Paes Leme et al., 2011
serotransferrin	P02787	20-698	peptide-Leu153+Leu-peptide	N	MS	Pro	Ile	Gly	Leu	Leu	Tyr	Cys	Asp	Paes Leme et al., 2011
serotransferrin	P02787	20-698	peptide-Asn202+Gln-peptide	N	MS	Ser	Thr	Leu	Asn	Gln	Tyr	Phe	Gly	Paes Leme et al., 2011
serotransferrin	P02787	20-698	peptide-Met408+Ser-peptide	N	MS	Ala	Asp	Ala	Met	Ser	Leu	Asp	Gly	Paes Leme et al., 2011
serotransferrin	P02787	20-698	peptide-Tyr445+Phe-peptide	N	MS	Glu	Ala	Gly	Tyr	Phe	Ala	Ile	Ala	Paes Leme et al., 2011
serum albumin	Q56G89	1-609	peptide-Cys269+Cys-peptide	N	MS	His	Thr	Glu	Cys	Cys	His	Gly	Asp	Paes Leme et al., 2011
serum albumin	Q56G89	1-609	peptide-Leu90+His-peptide	N	MS	Asp	Lys	Ser	Leu	His	Thr	Leu	Phe	Paes Leme et al., 2011
serum albumin	Q56G89	1-609	peptide-Pro327+Ser-peptide	N	MS	Ala	Asp	Leu	Pro	Ser	Leu	Ala	Ala	Paes Leme et al., 2011
uncharacterized protein	C9JV77	1-368	peptide-Cys89+His-peptide	N	MS	Glu	Thr	Thr	Cys	His	Val	Leu	Asp	Paes Leme et al., 2011
uncharacterized protein	C9JV77	1-368	peptide-Phe181+Gln-peptide	N	MS	Gly	Ser	Asn	Phe	Gln	Leu	Glu	Glu	Paes Leme et al., 2011