Substrates for peptidase S01.101: trypsin (Streptomyces griseus-type)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
alpha-2-macroglobulin	P01023	24-1474	peptide-Arg704+Val-peptide	P	Glu	Gly	Leu	Arg	Val	Gly	Phe	Tyr	Mortensen et al., 1981
alpha-2-macroglobulin	P01023	24-1474	peptide-Arg719+Leu-peptide	P	Gly	His	Ala	Arg	Leu	Val	His	Val	Mortensen et al., 1981
bowman-Birk type bran trypsin inhibitor precursor	P07084		peptide-Lys201+Met-peptide	N	Phe	Cys	Asn	Lys	Met	Asn	Pro	Pro	Tashiro et al., 1987
bowman-Birk type bran trypsin inhibitor precursor	P07084		peptide-Arg225+Val-peptide	N	Asp	Cys	Gln	Arg	Val	Glu	Ser	Ser	Tashiro et al., 1987
Bz-Arg-NHPhNO2 (BAPNA)			Bz-Arg+NHPhNO2	S	-	-	Bz	Arg	NAN	-	-	-
Bz-Arg-OEt [BAEE]			Bz-Arg+OEt	S	-	-	Bz	Arg	OEt	-	-	-	Wang et al., 2019
Bz-Arg-p-NHPhNO2 (BAPAN)			Bz-Arg+	S	-	-	Bz	Arg	NAN	-	-	-	Wang et al., 2019
Suc-Ala-Ala-Pro-Trp-NHMec			Suc-Ala-Ala-Pro-Trp+NHMec	S	Ala	Ala	Pro	Trp	AMC	-	-	-