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Peptidase

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Substrates for peptidase M12.144: atrolysin C

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Abz-Ala-Gly-Leu-Ala-Nba Abz-Ala-Gly+Leu-Ala-Nba S - Abz Ala Gly Leu Ala Nba - Fox et al., 1986
ac-Ala-Ala-Leu-Gly-Ala ac-Ala-Ala+Leu-Gly-Ala S - Ac Ala Ala Leu Gly Ala - Fox et al., 1986
ac-Glu-Ala-Leu-Gly-Ala ac-Glu-Ala+Leu-Gly-Ala S - Ac Glu Ala Leu Gly Ala - Fox et al., 1986
ac-Val-Ala-Ala-Leu-Gly-Ala ac-Val-Ala-Ala+Leu-Gly-Ala S Ac Val Ala Ala Leu Gly Ala - Fox et al., 1986
ac-Val-Ala-Leu-Gly-Ala ac-Val-Ala+Leu-Gly-Ala S - Ac Val Ala Leu Gly Ala - Fox et al., 1986
ac-Val-Ala-Leu-Gly-Gly ac-Val-Ala+Leu-Gly-Gly S - Ac Val Ala Leu Gly Gly - Fox et al., 1986
ac-Val-Ala-Leu-Leu-Ala ac-Val-Ala+Leu-Leu-Ala S - Ac Val Ala Leu Leu Ala - Fox et al., 1986
ac-Val-Ala-Phe-Gly-Ala ac-Val-Ala+Phe-Gly-Ala S - Ac Val Ala Phe Gly Ala - Fox et al., 1986
ac-Val-Gly-Leu-Gly-Ala ac-Val-Gly+Leu-Gly-Ala S - Ac Val Gly Leu Gly Ala - Fox et al., 1986
aggrecan core protein P16112 17-2415 peptide-Asn341+Phe-peptide N Ile Pro Glu Asn Phe Phe Gly Val Fox, 2004 16774
aggrecan core protein P16112 17-2415 peptide-Glu373+Ala-peptide N Thr Glu Gly Glu Ala Arg Gly Ser Tortorella et al., 1998 19830
aggrecan core protein P13608 17-2364 peptide-Ser360+Phe-peptide P Ile Pro Glu Ser Phe Phe Gly Val Tortorella et al., 1998 19831
aggrecan core protein P13608 17-2364 peptide-Glu392+Ala-peptide P Thr Glu Gly Glu Ala Arg Gly Ser Tortorella et al., 1998 16775
alpha-1-peptidase inhibitor P01009 25-418 peptide-Ala166+Phe-peptide N MS His Ser Glu Ala Phe Thr Val Asn Paes Leme et al., 2010
alpha-1-peptidase inhibitor P01009 25-418 peptide-Phe232+His-peptide N MS Glu Glu Asp Phe His Val Asp Gln Paes Leme et al., 2010
alpha-2-macroglobulin P01023 24-1474 peptide-Arg696+Leu-peptide N Gly His Ala Arg Leu Val His Val Fox, 2004 16776
alpha-2-macroglobulin P01023 24-1474 peptide-Asn1413+His-peptide N MS Val Ser Ser Asn His Val Leu Ile Paes Leme et al., 2010
alpha-2-macroglobulin P01023 24-1474 peptide-Pro832+Ala-peptide N MS Glu Ala Ser Pro Ala Phe Leu Ala Paes Leme et al., 2010
alpha-2-macroglobulin P01023 24-1474 peptide-Ala833+Phe-peptide N MS Ala Ser Pro Ala Phe Leu Ala Val Paes Leme et al., 2010
alpha-2-macroglobulin P01023 24-1474 peptide-Ala1108+Leu-peptide N MS Ile Thr Ile Ala Leu Leu Glu Ile Paes Leme et al., 2010
alpha-2-macroglobulin P01023 24-1474 peptide-Pro1113+Leu-peptide N MS Leu Glu Ile Pro Leu Thr Val Thr Paes Leme et al., 2010
alpha-2-macroglobulin P01023 24-1474 peptide-Ala324+Gln-peptide N MS His Thr Glu Ala Gln Ile Gln Glu Paes Leme et al., 2010
alpha-2-macroglobulin P01023 24-1474 peptide-Ser616+Ser-peptide N MS Leu Ser Ala Ser Ser Val Tyr Asn Paes Leme et al., 2010
alpha-2-macroglobulin P01023 24-1474 peptide-Cys1321+Val-peptide N MS Gly Glu Gly Cys Val Tyr Leu Gln Paes Leme et al., 2010
aminoacyl-Ile bond peptide-Xaa+Ile-peptide N - - NPe Xaa Ile CPe - - Fox, 2004
aminoacyl-Leu bond peptide-Xaa+Leu-peptide N - - NPe Xaa Leu CPe - - Fox, 2004
aminoacyl-Met bond peptide-Xaa+Met-peptide N - - NPe Xaa Met CPe - - Fox, 2004
aminoacyl-Val bond peptide-Xaa+Val-peptide N - - NPe Xaa Val CPe - - Fox, 2004
fLJ00385 protein Q8NF17 1-509 peptide-Gly395+Ser-peptide N MS Asp Ser Asp Gly Ser Phe Phe Leu Paes Leme et al., 2010
fLJ00385 protein Q8NF17 1-509 peptide-Pro231+Ser-peptide N MS Leu Gly Gly Pro Ser Val Phe Leu Paes Leme et al., 2010
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His+Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Val Asn Gln His Leu Cya Gly Ser Fox et al., 1986 24399
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala+Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Leu Val Glu Ala Leu Tyr Leu Val Fox et al., 1986 24401
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly+Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Gly Glu Arg Gly Phe Phe Tyr Thr Fox et al., 1986 24403
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His+Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Cya Gly Ser His Leu Val Glu Ala Fox et al., 1986 24400
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr+Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Glu Ala Leu Tyr Leu Val Cya Gly Fox et al., 1986 24402
putative uncharacterized protein Q8TCD0 1-239 peptide-Val158+Cys-peptide N MS Ala Ser Val Val Cys Leu Leu Asn Paes Leme et al., 2010
putative uncharacterized protein Q8TCD0 1-239 peptide-Cys159+Leu-peptide N MS Ser Val Val Cys Leu Leu Asn Asn Paes Leme et al., 2010
putative uncharacterized protein Q8TCD0 1-239 peptide-Ser156+Val-peptide N MS Gly Thr Ala Ser Val Val Cys Leu Paes Leme et al., 2010
putative uncharacterized protein Q8TCD0 1-239 peptide-Ala178+Leu-peptide N MS Val Asp Asn Ala Leu Gln Ser Gly Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-Tyr445+Phe-peptide N MS Glu Ala Gly Tyr Phe Ala Ile Ala Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-Thr112+Phe-peptide N MS Asp Pro Gln Thr Phe Tyr Tyr Ala Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-Glu243+Leu-peptide N MS Asp Gln Tyr Glu Leu Leu Cys Leu Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-Glu579+Leu-peptide N MS Lys Asp Tyr Glu Leu Leu Cys Leu Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-Gly152+Leu-peptide N MS Ile Pro Ile Gly Leu Leu Tyr Cys Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-Leu153+Leu-peptide N MS Pro Ile Gly Leu Leu Tyr Cys Asp Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-Ala263+Gln-peptide N MS Cys His Leu Ala Gln Val Pro Ser Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-Asn202+Gln-peptide N MS Ser Thr Leu Asn Gln Tyr Phe Gly Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-Gly444+Tyr-peptide N MS Pro Glu Ala Gly Tyr Phe Ala Ile Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-Cys260+His-peptide N MS Tyr Lys Asp Cys His Leu Ala Gln Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-Asp457+Leu-peptide N MS Ser Ala Ser Asp Leu Thr Trp Asp Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-Gly413+Phe-peptide N MS Leu Asp Gly Gly Phe Val Tyr Ile Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-Lys331+Met-peptide N MS Met Asp Ala Lys Met Tyr Leu Gly Paes Leme et al., 2010
serotransferrin P02787 20-698 peptide-Met332+Tyr-peptide N MS Asp Ala Lys Met Tyr Leu Gly Tyr Paes Leme et al., 2010
serum albumin Q56G89 1-609 peptide-Cys269+Cys-peptide N MS His Thr Glu Cys Cys His Gly Asp Paes Leme et al., 2010
serum albumin Q56G89 1-609 peptide-Pro327+Ser-peptide N MS Ala Asp Leu Pro Ser Leu Ala Ala Paes Leme et al., 2010
serum albumin Q56G89 1-609 peptide-Cys270+His-peptide N MS Thr Glu Cys Cys His Gly Asp Leu Paes Leme et al., 2010
serum albumin Q56G89 1-609 peptide-Glu177+Leu-peptide N MS Tyr Ala Pro Glu Leu Leu Phe Phe Paes Leme et al., 2010
serum albumin Q56G89 1-609 peptide-Asn482+Gln-peptide N MS Val Phe Leu Asn Gln Leu Cys Val Paes Leme et al., 2010
uncharacterized protein C9JV77 1-368 peptide-Asn180+Phe-peptide N MS Asn Gly Ser Asn Phe Gln Leu Glu Paes Leme et al., 2010
uncharacterized protein C9JV77 1-368 peptide-Cys89+His-peptide N MS Glu Thr Thr Cys His Val Leu Asp Paes Leme et al., 2010

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