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Peptidase

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Substrates for peptidase M12.138: jararhagin

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
alpha-1-inhibitor 3 precursor P14046 25-1477 peptide-Ala710+Val-peptide P Pro Val Val Ala Val Lys Ser Pro Anai et al., 1998
alpha-2-macroglobulin P01023 24-1474 peptide-Arg719+Leu-peptide N Gly His Ala Arg Leu Val His Val Anai et al., 1998
COL12A1 collagen, type XII, alpha 1 isoform 1 F1N401 peptide-Pro2018+Ala-peptide P Asn Pro Ser Pro Ala Gln Gly Arg Serrano et al., 2006 24409
COL12A1 collagen, type XII, alpha 1 isoform 1 F1N401 peptide-Ala2390+Leu-peptide P Lys Ala Leu Ala Leu Gly Ala Leu Serrano et al., 2006 24410
COL12A1 collagen, type XII, alpha 1 isoform 1 F1N401 peptide-Ala2393+Leu-peptide P Ala Leu Gly Ala Leu Gln Asn Ile Serrano et al., 2006 24411
COL12A1 collagen, type XII, alpha 1 isoform 1 F1N401 peptide-Ala2409+Leu-peptide P Thr Gly Lys Ala Leu Thr Phe Ile Serrano et al., 2006 24412
COL12A1 collagen, type XII, alpha 1 isoform 1 F1N401 peptide-Thr2411+Phe-peptide P Lys Ala Leu Thr Phe Ile Lys Glu Serrano et al., 2006 24413
COL12A1 collagen, type XII, alpha 1 isoform 1 F1N401 peptide-Lys2416+Val-peptide P Ile Lys Glu Lys Val Leu Thr Trp Serrano et al., 2006 24414
COL12A1 collagen, type XII, alpha 1 isoform 1 F1N401 peptide-Gly2423+Met-peptide P Trp Glu Ser Gly Met Arg Lys Asn Serrano et al., 2006 24415
COL12A1 collagen, type XII, alpha 1 isoform 1 F1N401 peptide-Ser2491+Phe-peptide P Asp Phe Glu Ser Phe Glu Lys Ile Serrano et al., 2006 24416
COL12A1 collagen, type XII, alpha 1 isoform 1 F1N401 peptide-Asn2498+Leu-peptide P Ile Glu Asp Asn Leu Ile Thr Phe Serrano et al., 2006 24417
COL12A1 collagen, type XII, alpha 1 isoform 1 F1N401 peptide-Thr2506+Ala-peptide P Val Cys Glu Thr Ala Thr Ser Ser Serrano et al., 2006 24418
Col14a1 collagen, type XIV, alpha 1 peptide-Asp119+Leu-peptide P Arg Ile Lys Asp Leu Glu Lys Arg Serrano et al., 2006 24419
Col14a1 collagen, type XIV, alpha 1 peptide-Ala1199+Phe-peptide P Asp Phe Asp Ala Phe Lys Lys Ile Serrano et al., 2006 24420
Col14a1 collagen, type XIV, alpha 1 peptide-Lys131+Val-peptide P Pro Arg Val Lys Val Val Asp Lys Serrano et al., 2006 24421
Col14a1 collagen, type XIV, alpha 1 peptide-Ser349+Ala-peptide P Ile Lys Ala Ser Ala Leu Ala Thr Serrano et al., 2006 24422
Col14a1 collagen, type XIV, alpha 1 peptide-Ala350+Leu-peptide P Lys Ala Ser Ala Leu Ala Thr Val Serrano et al., 2006 24423
Col14a1 collagen, type XIV, alpha 1 peptide-Lys1277+Tyr-peptide P Gln Pro Thr Lys Tyr Leu His Pro Serrano et al., 2006 24424
Col14a1 collagen, type XIV, alpha 1 peptide-Glu1178+Leu-peptide P Asp Tyr Ser Glu Leu Val Ser Ile Serrano et al., 2006
Col14a1 collagen, type XIV, alpha 1 peptide-Gly137+Glu-peptide P Asp Lys Gly Gly Glu Asn Lys Pro Serrano et al., 2006
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His+Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Cya Gly Ser His Leu Val Glu Ala Laing & Paine, 2004
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu+Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Val Glu Ala Leu Tyr Leu Val Cya Laing & Paine, 2004
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala+Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Leu Val Glu Ala Leu Tyr Leu Val Laing & Paine, 2004
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe+Phe-Tyr-Thr-Pro-Lys-Ala N Glu Arg Gly Phe Phe Tyr Thr Pro Laing & Paine, 2004
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His+Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Cya Gly Ser His Leu Val Glu Ala Fox et al., 1986
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala+Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Leu Val Glu Ala Leu Tyr Leu Val Fox et al., 1986
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr+Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Glu Ala Leu Tyr Leu Val Cya Gly Fox et al., 1986
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe+Phe-Tyr-Thr-Pro-Lys-Ala N Glu Arg Gly Phe Phe Tyr Thr Pro Fox et al., 1986
matrilin-3 O35701 28-481 peptide-Ala54+Leu-peptide P His Leu Ser Ala Leu Ala Thr Ser Serrano et al., 2006 24425
matrilin-3 O35701 28-481 peptide-Pro62+Tyr-peptide P Thr Arg Ala Pro Tyr Ser Gly Gly Serrano et al., 2006 24426
matrilin-3 O35701 28-481 peptide-Gly70+Val-peptide P Arg Gly Ala Gly Val Cys Lys Ser Serrano et al., 2006 24427
matrilin-3 O35701 28-481 peptide-Thr155+Met-peptide P Ser Thr Gly Thr Met Ser Gly Leu Serrano et al., 2006 24428
matrilin-3 O35701 28-481 peptide-Ala168+Phe-peptide P Met Glu Glu Ala Phe Thr Val Glu Serrano et al., 2006 24430
matrilin-3 O35701 28-481 peptide-Ser224+Leu-peptide P Asp Met Glu Ser Leu Lys Met Met Serrano et al., 2006 24432
matrilin-3 O35701 28-481 peptide-Lys226+Met-peptide P Glu Ser Leu Lys Met Met Ala Ser Serrano et al., 2006 24433
matrilin-3 O35701 28-481 peptide-Met228+Ala-peptide P Leu Lys Met Met Ala Ser Lys Pro Serrano et al., 2006 24434
matrilin-3 O35701 28-481 peptide-Lys248+Leu-peptide P Val Ile Glu Lys Leu Ser Ala Arg Serrano et al., 2006 24435
matrilin-3 O35701 28-481 peptide-Ser250+Ala-peptide P Glu Lys Leu Ser Ala Arg Phe Gln Serrano et al., 2006 24436
matrilin-3 O35701 28-481 peptide-Arg252+Phe-peptide P Leu Ser Ala Arg Phe Gln Glu Thr Serrano et al., 2006 24437
plasminogen P00747 20-810 peptide-Ser460+Val-peptide P NT Thr Glu Ala Ser Val Val Ala Pro Ho et al., 2001

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