Substrates for peptidase S01.231: urokinase-type plasminogen activator

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Ac-Ala-Ser-Gly-Lys-ACC			Ac-Ala-Ser-Gly-Lys+ACC	S		Ala	Ser	Gly	Lys	ACC	-	-	-	Gosalia et al., 2005
Ac-Ala-Thr-Ser-Lys-ACC			Ac-Ala-Thr-Ser-Lys+ACC	S		Ala	Thr	Ser	Lys	ACC	-	-	-	Gosalia et al., 2005
aggrecan core protein	P16112	17-2415	peptide-Val397+Ile-peptide	P		Arg	Gly	Ser	Val	Ile	Leu	Thr	Val	Fosang et al., 1998	18241
Boc-Leu-Gly-Arg-NHMec			Boc-Leu-Gly-Arg+NHMec	S		Boc	Leu	Gly	Arg	AMC	-	-	-
Glp-Gly-Arg-NHPhNO2			Glp-Gly-Arg+NHPhNO2	S		-	Glp	Gly	Arg	NAN	-	-	-	Ellis, 2004
Glt-Gly-Arg-NHMec			Glt-Gly-Arg+NHMec	S		-	Glt	Gly	Arg	AMC	-	-	-	Ellis, 2004
Hepatocyte growth factor	P14210	32-728	Peptide-Arg494+Val-Peptide	P	MU	Lys	Gln	Leu	Arg	Val	Val	Asn	Gly	Mars et al., 1993
hyaluronan-binding peptidase	Q14520	24-560	peptide-Arg313+Ile-peptide	N		Lys	Ile	Lys	Arg	Ile	Tyr	Gly	Gly	Kannemeier et al., 2001
integrin alpha-6	P23229	24-1130	peptide-Arg633+Arg-peptide	P		Pro	Ser	Ser	Arg	Arg	Arg	Val	Asn	Pawar et al., 2007	22055
plasminogen	P00747	20-810	peptide-Arg560+Val-peptide	P		Cys	Pro	Gly	Arg	Val	Val	Gly	Gly	Robbins et al., 1967	17423
S-2444			D-Glu-Gly-Arg+NHPhNO2	S		-	DGl	Gly	Arg	NAN	-	-	-	Amarant et al., 1991
small-inducible cytokine A14 precursor	Q16627	20-93	peptide-Arg27+Gly-peptide	P		Ser	Ser	Ser	Arg	Gly	Pro	Tyr	His	Vakili et al., 2001
upain-2			Cys-Ser-Trp-Arg+Gly-Leu-Glu-Asn-His-Ala-Ala-Cys	S		Cys	Ser	Trp	Arg	Gly	Leu	Glu	Asn	Jiang et al., 2018
upain-2(Trp3Ala,Arg4guanidinoPhe)			Cys-Ser-Ala-4-guanidinoPhe+Gly-Leu-Glu-Asn-His-Ala-Ala-Cys	S		Cys	Ser	Ala	Gnf	Gly	Leu	Glu	Asn	Jiang et al., 2018
urokinase plasminogen activator surface receptor	P35456	24-298	peptide-Arg107+Gly-peptide	P		Pro	Gly	Ala	Arg	Gly	Arg	Ala	Phe	Andolfo et al., 2002	19936
urokinase plasminogen activator surface receptor	Q03405	23-305	peptide-Arg105+Ala-peptide	P		Asn	Ser	Gly	Arg	Ala	Val	Thr	Tyr	Andolfo et al., 2002	17425
urokinase plasminogen activator surface receptor	Q03405	23-305	peptide-Arg111+Ser-peptide	P		Thr	Tyr	Ser	Arg	Ser	Arg	Tyr	Leu	Andolfo et al., 2002	19565
urokinase-type plasminogen activator	P00749	21-431	peptide-Lys23+Tyr-peptide	P		Val	Ser	Asn	Lys	Tyr	Phe	Ser	Asn	Ellis, 2004	17424
Z-Lys-SBzl			Z-Lys+SBzl	S		-	-	Z	Lys	SBz	-	-	-	Ellis, 2004