Substrates for peptidase M04.003: vibriolysin

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
cholera enterotoxin subunit A	P01555	19-258	Gly-Asn-Ala-Pro-Arg-Ser+Ser-Met-Ser-Asn-Thr	P		Ala	Pro	Arg	Ser	Ser	Met	Ser	Asn	Shinoda et al., 2004	16452
cholera enterotoxin subunit A	P01555	19-258	Gly-Asn-Ala-Pro-Arg-Ser-Ser+Met-Ser-Asn-Thr	P		Pro	Arg	Ser	Ser	Met	Ser	Asn	Thr	Shinoda et al., 2004	16453
Coagulation factor XII	P00748	20-615	Peptide-Arg372+Val-Peptide	N	NT	Ser	Met	Thr	Arg	Val	Val	Gly	Gly	Miyoshi et al., 2004
Coagulation factor XII	P00748	20-615	Peptide-Gly376+Leu-Peptide	N	NT	Val	Val	Gly	Gly	Leu	Val	Ala	Leu	Miyoshi et al., 2004
El Tor cytolysin			Ala-Ala-Ser-Gly+Phe-Ala-Ser-Pro	N		Ala	Ala	Ser	Gly	Phe	Ala	Ser	Pro	Shinoda et al., 2004
furylacryloyl-Ala-Phe-NH2 (FAAFA)			furylacryloyl-Ala+Phe-NH2	S		-	-	FA	Ala	Phe	NH2	-	-	Durham, 1998
furylacryloyl-Gly-Ala-NH2			furylacryloyl-Gly+Ala-NH2	S		-	-	FA	Gly	Ala	NH2	-	-	Durham, 1998
matrix metallopeptidase-1 precursor	P03956	20-469	peptide-Val101+Leu-peptide	N		Ala	Gln	Phe	Val	Leu	Thr	Glu	Gly	Okamoto et al., 1997	19813
matrix metallopeptidase-1 precursor	P03956	100-469	peptide-Pro269+Ile-peptide	N		Pro	Val	Gln	Pro	Ile	Gly	Pro	Gln	Okamoto et al., 1997
matrix metallopeptidase-9	P14780		peptide-Thr109+Phe-peptide	N		Arg	Phe	Gln	Thr	Phe	Glu	Gly	Asp	Okamoto et al., 1997	19817
neutral protease	Q00971	25-609	peptide-His196+Ala-peptide	P	NT	Gly	Leu	Asn	His	Ala	Gln	Ala	Asp	David et al., 1992
Plasma kallikrein heavy chain	P03952	20-615	Peptide-Arg390+Ile-Peptide	N	NT	Thr	Ser	Thr	Arg	Ile	Val	Gly	Gly	Miyoshi et al., 2004
Plasminogen	P00747	20-810	Peptide-Tyr99+Leu-Peptide	N	NT	Lys	Lys	Val	Tyr	Leu	Ser	Glu	Cys	Chang et al., 2005
Prothrombin	P00734	44-622	Peptide-Asp250+Phe-Peptide	N	NT	Lys	His	Gln	Asp	Phe	Asn	Ser	Ala	Chang et al., 2005
Prothrombin	P00734	44-622	Peptide-Thr315+Ala-Peptide	N	NT	Glu	Gly	Arg	Thr	Ala	Thr	Ser	Glu	Chang et al., 2005
Z-Gly-Leu-NH2			Z-Gly+Leu-NH2	S		-	-	Z	Gly	Leu	NH2	-	-	Shinoda et al., 2004
Z-Gly-Phe-NH2			Z-Gly+Phe-NH2	S		-	-	Z	Gly	Phe	NH2	-	-	Shinoda et al., 2004