Substrates for peptidase S01.232: t-plasminogen activator

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Ac-Ala-Phe-Gly-Lys-ACC			Ac-Ala-Phe-Gly-Lys+ACC	S		Ala	Phe	Gly	Lys	ACC	-	-	-	Gosalia et al., 2005
Ac-Ala-Tyr-Thr-Lys-ACC			Ac-Ala-Tyr-Thr-Lys+ACC	S		Ala	Tyr	Thr	Lys	ACC	-	-	-	Gosalia et al., 2005
Boc-Leu-Gly-Arg-NHPhNO2			Boc-Leu-Gly-Arg+NHPhNO2	S		Boc	Leu	Gly	Arg	NAN	-	-	-
GRIN1	Q05586	19-939	peptide-Arg260+Tyr-peptide	P	MS	Asn	Ala	Leu	Arg	Tyr	Ala	Pro	Asp	Fernandez-Monreal et al., 2004	19162
H-D-Ile-Pro-Arg-NHPhNO2			H-D-Ile-Pro-Arg+NHPhNO2	S		-	DIl	Pro	Arg	NAN	-	-	-	Lijnen & Collen, 2004
plasminogen	P00747	20-810	peptide-Arg561+Val-peptide	P		Cys	Pro	Gly	Arg	Val	Val	Gly	Gly	Anglés-Cano & Rojas, 2002	17427
plasminogen activator inhibitor-1	P05121	24-402	peptide-Arg369+Met-peptide	P	NT	Val	Ser	Ala	Arg	Met	Ala	Pro	Glu	Declerck et al., 1992
SERPINI1	Q99574	17-410	peptide-Arg362+Met-peptide	P		Ala	Ile	Ser	Arg	Met	Ala	Val	Leu	Barker-Carlson et al., 2002	3428
tissue-type plasminogen activator	P00750	23-562	peptide-Arg310+Ile-peptide	P		Pro	Gln	Phe	Arg	Ile	Lys	Gly	Gly	Tate et al., 1987	19601